Gastrointestinale Manifestationen beim erworbenen Immunmangelsyndrom (AIDS)

Krämer A, Riecken E-O. Gastrointestinale Manifestationen beim erworbenen Immunmangelsyndrom (AIDS). AIDS-Forschung. 1986;1(8):405-420

German experimental hepatitis B vaccine: influence of variation of dosage schedule, sex and age differences on immunogenicity in health care workers

Krämer A, Sommer D, Hahn EG, Riecken E-O. German experimental hepatitis B vaccine: influence of variation of dosage schedule, sex and age differences on immunogenicity in health care workers. Klinische Wochenschrift. 1986;64(15):688-694

Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing

Krämer A, Herth D, von Keyserlingk H, et al. Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift. 1988;66(15):670-674.The variation in immune responses to standard inoculation of the hepatitis-B virus vaccine suggest that host factors influence response in ways that are not presently understood. We studied 25 low/nonresponding health care workers (anti-HBs titer 10 IU/l. Almost all subjects had normal B-cell and CD-4 and CD-8 counts and ratios. Relative to other European populations HLA-A-10 (P<0.05), B-12 (P<0.025), CW-5 (P<0.05), DR-3 (P<0.025), and DR-5 (P<0.025) were increased, whereas DR-2 (P<0.05) was decreased. However, after correction of theP-values for the number of HLA antigens determined, these differences were no longer significant. Furthermore, these HLA types were not the same as those reported in other studies (except for DR-3). We suggest that larger sample sizes or even not yet available immunogenetic markers will be required to prove an "immunogenetic background" in low/nonresponders, if it exists

Besondere gastrointestinale Manifestationen einer generalisierten Zytomegalievirus-Infektion bei einem Patienten mit erworbenem Immundefektsyndrom

Krämer A, Petersen K, Schmidt B, Menge H, Gross U, Riecken E-O. Besondere gastrointestinale Manifestationen einer generalisierten Zytomegalievirus-Infektion bei einem Patienten mit erworbenem Immundefektsyndrom. Deutsche medizinische Wochenschrift. 1985;110(12):462-468.Bei einem Patienten mit erworbenem Immundefektsyndrom (AIDS) beherrschte eine schwere Zytomegalievirus-(CMV-)Infektion mit Manifestationen am Gastrointestinaltrakt und an der Retina das klinische Bild. Die gastrointestinale Symptomatik - Durchfälle und rezidivierendes Erbrechen - fand autoptisch in einer Zerstörung der Tunica muscularis des Digestionstraktes ihr Korrelat. Die CMV-Retinitis führte zu fast vollständigem Visusverlust; dies war die Folge einer weitgehenden Zerstörung der Retina. Außer der generalisierten CMV-Infektion und einem disseminierten Kaposi-Sarkom, das sich ebenfalls am Gastrointestinaltrakt manifestierte und dort vergleichsweise diskrete pathologisch-anatomische Veränderungen verursachte, war bei der Autopsie noch ein malignes Lymphom des Gehirns vorhanden.In a patient with AIDS, severe cytomegalovirus (CMV) infection dominated with gastro-intestinal and retinal involvement. The gastro-intestinal signs - diarrhoea and recurrent vomiting - correlated with the destruction of the tunica muscularis of the digestive tract seen at post-mortem. The CMV retinitis caused an almost complete loss of sight, the consequence of extensive destruction of the retina. In addition to the generalized CMV infection and disseminated Kaposi's sarcoma, which also involved the gastro-intestinal tract and caused discrete histopathological changes, post-mortem examination revealed a malignant lymphoma of the brain