Rectal and oral absorption of methylprednisolone acetate

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117227/1/cpt1979262232.pd

Bioavailability of diphenylhydantoin

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117110/1/cpt1974164727.pd

Correlation of plasma levels of digoxin in cardiac patients with dose and measures of renal function

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117126/1/cpt1974153291.pd

Determination of myocardial and serum digoxin concentrations in children by specific and nonspecific assay methods

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109866/1/cptclpt198378.pd

Blood ethanol concentrations during and following constant‐rate intravenous infusion of alcohol

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117025/1/cpt1976192213.pd

Pharmacokinetics of diphenhydramine in man

Plasma levels and urinary excretion of diphenhydramine were measured after administration of three single 50-mg doses of diphenhydramine hydrochloride to two healthy male volunteers as an intravenous infusion, an oral solution, and a commercially available capsule. A large first- pass effect was evident from the data, with about 50% of the drug being metabolized by the liver before it reached the general circulation. The drug in solution given orally appeared to be fully available to the hepatoportal system, and the availability of diphenhydramine from the capsule was about 83% relative to the solution in one subject and 100% in the other subject. Cumulative amounts of unchanged diphenhydramine excreted in the urine were less than 4% of the administered dose. Both subjects went to sleep at the end of the 1-hr intravenous infusion, but were only drowsy following the oral treatments .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45060/1/10928_2005_Article_BF01067905.pd

In Vitro and In Vivo availability of some commercial prednisolone tablets

The in vitro dissolution rates of prednisolone from five commercially available 5- mg prednisolone tablets were determined in distilled water. The dissolution studies were repeated on the fastest- and slowest-dissolving brands using 0.01% polysorbate 80 in 0.1 N HCl as the dissolution medium. A two-way crossover bioavailability study was performed in 12 human male adult volunteers comparing the fastest- and slowest-dissolving brands. The plasma samples were assayed for prednisolone by a radioimmunoassay method. Statistical analysis of the data for the two brands showed no significant differences between average plasma levels of prednisolone at any sampling time. The results suggest that on the average the in vivo rates of dissolution of the two brands were essentially the same, and in vitro dissolution in 0.01% polysorbate 80–0.1 N HCl medium was better correlated with these in vivo results than dissolution in water .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45041/1/10928_2005_Article_BF01062144.pd

Comparative bioavailability: A new type of in vitro-in vivo correlation exemplified by prednisone

The average time to reach half-maximal plasma concentration of prednisolone and the average plasma concentrations of prednisolone at 0.5 and 1 hr obtained from three crossover bioavailability studies, involving testing of commercially available 5-mg prednisone tablets, were highly correlated (r⪖ 0.88) with parameters derived from in vitro tablet dissolution rates performed in the spin filter apparatus of Shah. The in vitro parameters were the times to dissolve 16% or 50% of the labeled amount of prednisone or the percent of the labeled amount of prednisone dissolved in 20 min in water at 37‡C. Such correlations may be useful in the setting of in vitro dissolution rate specifications for commencal prednisone tablets .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45065/1/10928_2005_Article_BF01086152.pd

Comparative bioavailability: Eight commercial prednisone tablets

Two four-treatment crossover bioavailability studies were performed in panels of 12 adult male volunteers with eight different commercial prednisone tablets. Plasma samples from the first study were assayed by radioimmunoassay for both prednisone and prednisolone. Plasma samples from the second study were assayed for prednisolone only. Statistical analyses of the data showed significant differences in the rate of appearance of prednisolone in plasma, but not in the amount convened to prednisolone. Some observations are made on the relationships between prednisone and prednisolone concentrations in plasma following oral administration of prednisone .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45064/1/10928_2005_Article_BF01086151.pd

Bioavailability of prednisolone tablets

Two fourtreatment crossover studies were performed using 12 adult male volunteers in each with seven different commercially available prednisolone tablets. Plasma samples were assayed for prednisolone by a radioimmunoassay method. Statisacal analyses of the data, by analysis of variance for crossover design (ANOVA), showed no significant differences among the treatment averages at any of the sampling times except at 0.25 and 4 hr in one of the studies. There were also no significant differences among the treatment averages for peak plasma level, time of peak plasma level, area 0–12 hr, area 0–24 hr, and the halflife of elimination of prednisolone. We conclude that the average plasma concentrations of prednisolone are superimposable in a statistical sense and that the tablets tested are bioequivalent. Results of dissolution studies of six tablets of each of the seven lots of prednisolone tablets, using deaerated water in the spin filter apparatus, are presented.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45072/1/10928_2005_Article_BF01065399.pd