Karakterizacija endokrino-metaboličkog profila koji se koristi za procjenu funkcije štitnjače kod pasa pasmina engleski i francuski buldog

This study investigates whether breed or gender affect serum hormone and metabolite concentrations used to evaluate thyroid function in the Bulldog breed. Sixty-seven healthy adult English Bulldogs (n = 20), French Bulldogs (n = 17), German Shepherds (n = 15) and mongrels (n = 15) of both sexes were selected. Determination of serum total thyroxine (TT4), free thyroxine (FT4), and thyroid stimulating hormone (TSH) was performed via a competitive enzymatic chemiluminescent solid-phase immunoassay. Cholesterol and triglyceride concentrations were analyzed by spectrophotometry. Serum concentrations of TT4, FT4, TSH, cholesterol, and triglycerides for French and English Bulldogs were within the international reference ranges for the canine population. Breed had a significant effect on serum levels of TT4 (P = 0.0012) and FT4 (P<0.0001); English and French Bulldogs had higher serum TT4 and FT4 concentrations than German Shepherds and mongrels. Gender had a significant effect only on serum FT4 levels; females exhibited higher levels (P = 0.0309). Cholesterol, triglycerides, and TSH serum concentrations did not differ with breed or gender. Healthy French and English Bulldogs included in this study had higher serum concentrations of TT4 and FT4 compared with German Shepherds and mongrels, and the concentration of FT4 was also higher in females.Ovim radom istraženo je utječu li pasmina i spol na koncentracije hormona i metabolita u serumu koji služi za procjenu funkcije štitnjače u pasa pasmine buldog. Uključeno je ukupno šezdeset i sedam odraslih zdravih pasa oba spola, među kojima je bilo 20 engleskih buldoga, 17 francuskih buldoga, 15 njemačkih ovčara i 15 križanaca. Ukupni tiroksin (TT4), slobodni tiroksin (FT4) i hormon koji stimulira štitnjaču (TSH) određeni su pomoću kompetitivne enzimske kemiluminoscentne imunoanalize. Koncentracije kolesterola i triglicerida analizirane su spektrofotometrijom. Koncentracije TT4, FT4, TSH, kolesterola i triglicerida u serumu za francuske i engleske buldoge bile su unutar međunarodnih referentnih raspona za populaciju pasa. Pasmina je imala signifikantan učinak na razinu TT4 (p = 0,0012) i FT4 (p< 0,0001) u serumu, pri čemu su engleski i francuski buldozi imali veće koncentracije TT4 i FT4 u serumu nego njemački ovčari i križanci. Spol je imao signifikantan utjecaj samo na razinu FT4 u serumu, pri čemu je ta razina bila viša kod ženki (p = 0,0309). Kolesterol, trigliceridi i koncentracije TSH seruma nisu se razlikovali ovisno o pasmini ili spolu. Zdravi francuski i engleski buldozi uključeni u ovo istraživanje su, u usporedbi s njemačkim ovčarima i križancima, imali veće koncentracije TT4 i FT4 u serumu. Također, koncentracija FT4 u serumu bila je viša kod ženki

Clustering Suicide Attempters: Impulsive-Ambivalent, Well-Planned, or Frequent

International audienceBACKGROUND:Attempts to predict suicidal behavior within high-risk populations have so far shown insufficient accuracy. Although several psychosocial and clinical features have been consistently associated with suicide attempts, investigations of latent structure in well-characterized populations of suicide attempters are lacking.METHODS:We analyzed a sample of 1,009 hospitalized suicide attempters that were recruited between 1999 and 2012. Eleven clinically relevant items related to the characteristics of suicidal behavior were submitted to a Hierarchical Ascendant Classification. Phenotypic profiles were compared between the resulting clusters. A decisional tree was constructed to facilitate the differentiation of individuals classified within the first 2 clusters.RESULTS:Most individuals were included in a cluster characterized by less lethal means and planning ("impulse-ambivalent"). A second cluster featured more carefully planned attempts ("well-planned"), more alcohol or drug use before the attempt, and more precautions to avoid interruptions. Finally, a small, third cluster included individuals reporting more attempts ("frequent"), more often serious or violent attempts, and an earlier age at first attempt. Differences across clusters by demographic and clinical characteristics were also found, particularly with the third cluster whose participants had experienced high levels of childhood abuse.CONCLUSIONS:Cluster analysis consistently supported 3 distinct clusters of individuals with specific features in their suicidal behaviors and phenotypic profiles that could help clinicians to better focus prevention strategies