Development Of Advanced Multifunctional Neural Interface Devices

The fine micro-architecture of neural tissue complicates efforts to create neural interface hardware capable of high resolution input and output from neural circuitry. Microtechnology provides a unique opportunity to create neural interface hardware with efficiency and precision that is capable of utilizing multiple modalities for recording and stimulating neural activity. In this thesis work, we investigate the application of silicon-parylene hybrid micro-structures for the creation of novel microtechnology based neural interface devices capable of electrical, chemical, and optical interrogation of neural tissue activity. Specifically, we explore the creation of the following devices: 1) microstructured neural probes with microfluidic delivery for chronic suppression of tissue response, 2) integration of optics including optical fibers and waveguides into neural probes, and 3) development of a mechanically tunable microfabricated cochlear implant probe for use in rats