Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma

Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265Funder: Good Will CauseFunder: MRC/EPSRC Newcastle Pathology NodeFunder: Newcastle upon Tyne Hospitals NHS Foundation Trust (Newcastle upon Tyne Hospitals NHS Trust); doi: https://doi.org/10.13039/501100003776Funder: Blood Cancer UK - Senior Bennett Fellowship #12005 North East Promenaders Against Cancer (NEPAC) The Little Princess Trust JGW Patterson FoundationAbstract: Children with B-cell non-Hodgkin lymphoma (B-NHL) have an excellent chance of survival, however, current clinical risk stratification places as many as half of patients in a high-risk group receiving very intensive chemo-immunotherapy. TP53 alterations are associated with adverse outcome in many malignancies; however, whilst common in paediatric B-NHL, their utility as a risk classifier is unknown. We evaluated the clinical significance of TP53 abnormalities (mutations, deletion and/or copy number neutral loss of heterozygosity) in a large UK paediatric B-NHL cohort and determined their impact on survival. TP53 abnormalities were present in 54.7% of cases and were independently associated with a significantly inferior survival compared to those without a TP53 abnormality (PFS 70.0% vs 100%, p < 0.001, OS 78.0% vs 100%, p = 0.002). Moreover, amongst patients clinically defined as high-risk (stage III with high LDH or stage IV), those without a TP53 abnormality have superior survival compared to those with TP53 abnormalities (PFS 100% vs 55.6%, p = 0.005, OS 100% vs 66.7%, p = 0.019). Biallelic TP53 abnormalities were either maintained from the presentation or acquired at progression in all paired diagnosis/progression Burkitt lymphoma cases. TP53 abnormalities thus define clinical risk groups within paediatric B-NHL and offer a novel molecular risk stratifier, allowing more personalised treatment protocols

IT-Toolkit für energieeffiziente Sanierungsmaßnahmen: Ein neues internationales Planungsinstrument für öffentliche Gebäude mit deutschen Bewertungsansätzen

Öffentliche Gebäude wie Schulen, Verwaltungs- und Beherbergungsgebäude, Produktionsstätten und Wartungseinrichtungen stellen spezifische Anforderungen an Verbesserungen in der Energieversorgung und im Energieverbrauch von Gebäuden

The Energy Concept Adviser - a tool to improve energy efficiency in educational buildings

Educational buildings such as kindergartens, schools and universities display many similar design, operation and maintenance features in most countries. The two most noteworthy similarities amongst these building types are the high energy consumption and the necessity for retrofitting many buildings within this sector. However, studies have shown that during retrofit, energy saving measures are only rarely applied, because the decision-makers lack knowledge of investments and the efficiency of potential energy saving measures. The main goal of the International Energy Agency ECBCS Annex 36 is to provide the educational building decision-makers with sufficient data, information and tools to improve their learning and teaching environments by improving the energy efficiency of their buildings. This is the background for the development of an Energy Concept Adviser (ECA) for energy and financial retrofit measures that is useful during the planning and concept development phases for educational buildings. On the one hand to help the owner to find the most efficient energy saving measures and on the other hand to prevent that exaggerated expectations are raised. The ECA should be applicable during the entire retrofitting phase to ensure that both the calculated energy savings and financial success will be achieved after retrofitting. This paper describes a tool that assists educational building decision-makers while the construction project is still in the design phase. This tool will improve new or existing buildings through the identification and calculation of potential energy savings. The ECA includes suggestions of energy systems to use and potential design concepts to be considered during the design phase. During the past 6 years, data have been gathered from all the 10 participating countries of the Annex 36. This electronic Internet-based tool incorporates an interactive source book of information, which includes design concepts, design advise, design and decision programs, and case studies. The tool has been translated into several languages

Passive Solarenergienutzung in bewohnten Eigenheimen - Messergebnisse und energetische Analyse fuer das Solarhaus in Ingelheim

With 4 tabs., 12 figs.TIB Hannover: RN 5905(2114) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Passive Solarenergienutzung in bewohnten Eigenheimen - Messergebnisse und energetische Analyse fuer das Solarhaus in Waldmohr

With 4 tabs., 12 figs.TIB Hannover: RN 5905(2109) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Passive Solarenergienutzung in bewohnten Eigenheimen - Messergebnisse und energetische Analyse fuer das Solarhaus bei Issum

With 4 tabs., 12 figs.TIB Hannover: RN 5905(2113) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Passive Solarenergienutzung in bewohnten Eigenheimen - Messergebnisse und energetische Analyse fuer das Solarhaus in Landstuhl

With 4 tabs., 12 figs.TIB Hannover: RN 5905(2104) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Passive Solarenergienutzung in bewohnten Eigenheimen - Messergebnisse und energetische Analyse fuer das Solarhaus in Woellstein

With 4 tabs., 12 figs.TIB Hannover: RN 5905(2115) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman