Histopathological distribution of thyroid cancers: A retrospective analysis of 570 patients

Aim: Thyroid cancers are the most commonly encountered endocrine system malignancies.  The incidence continues to rise worldwide. Our aim in this study is to investigate the frequency and histopathological subtypes of thyroid cancer in our clinic. Methods: The present study was conducted with 3614 patients who were followed up in our endocrinology and general surgery clinic and operated with the diagnosis of multinodular and/or nodular goiter between 2015 and 2021. The histopathological types and information of patients diagnosed with thyroid cancer were obtained retrospectively from the pathology reports. Among the patients included in the study, a total of 570 people who were reported to have thyroid cancer due to histopathology were included in the study. Results: The data of a total of 3614 biopsy reports were examined for the study. Among these patients, 570 (421 females, 149 males) were operated and whose pathology reports were accessed were included in the study. The mean age of the patients was 49.12±10.4 years. As a result of the operations, malign postoperative tissue histopathology was 98.9% (n=564), and uncertain malignancy potential was reported to be 1.0% (n=6). In our study, the histopathological distribution of thyroid cancers was as follows; thyroid papillary cancer 89.4% (n=510), follicular cancer 7.3% (n=42), medullary cancer 2.1% (n=12), and malignancy potential uncertain 1.0% (n=6). Conclusion: The results of our study suggest that thyroid cancers are more common in women in our country, in parallel with the similar rates reported in the literature, with the increase worldwide

Investigating Anxiety, Depression and Obsessive-Compulsive Disorders (OCD) among healthcare workersin COVID-19 unit and the control group

To investigate anxiety, depression, and Obsessive-Compulsive Disorders (OCDs) among the healthcare workers (HCWs) to compare the healthcare workers in COVID positive services with the control group. This cross-sectional study was conducted on 198 subjects participating in the study. To test the difference between the two groups involved in COVID-19 hospitalization section and normal section in Anxiety, Depression, and Obsessive-Compulsive Disorders Scale, two sample independent t-tests, however, WelchSatterthwaite P Values were considered for test significance. The categorical variables (sex, branch type, etc.) were also tested using the Chi-Square test to make sure that the two samples were not influenced by the demographics of the population. 198 subjectspartici pated in the study, among whom 72% were female and 28.3% were male. 130 participants (66%) worked in COVID and 68 participants (35%) worked in other sections.The mean age of the two samples was close to 35 and most of them (~45%) were nurses. 57% of the pooled samples had Emergency Response Experience (ERE).There was no significant difference between the two groups regarding sex, education, marital status, and ERE, however, the branch type showed major differences between the two groups(P-value < 0.08). The age difference between the two groups was also insignificant. Working in the COVID-19 section significantly increased anxiety scores from 9.62 to 13.15 with a P-value of [Med-Science 2020; 9(4.000): 1072-5

The relationship between vitamin D deficiency and erythrocyte sedimentation rate in patients with diabetes

Conclusion: The present study revealed that ESR is higher in T2DM patients with vitamin D deficiency than patients with sufficient vitamin D. There was an inverse association between ESR and vitamin D levels. Furthermore, vitamin D deficiency was related to poor glycemic control

The relationship between neutrophil to lymphocyte ratio and metabolic syndrome in patients with type 2 diabetes

Metabolic syndrome (MetS) has been shown to be associated with inflammation. However, in diabetic patients with MetS, its relationship with the neutrophil to lymphocyte ratio (NLR) as a novel inflammation marker is unclear. The aim of the study was to investigate the association between NLR and MetS in patients with type 2 diabetes mellitus. It was a cross-sectional study which included 261 consecutive patients (mean age 56.7 +/- 10.5 years, 56.7% female) with type 2 diabetes. NLR and other clinical and laboratory parameters of patients with and without MetS were evaluated. The prevalence of MetS was 85.8%. The NLR was higher in patients with MetS than without MetS (p = 0.001). There was a significant correlation between the NLR and the number of MetS components (r = 0.147, p = 0.017). Logistic regression analysis showed that an elevated NLR value was an independent predictor of MetS. The receiver operating curve analysis suggested that the optimum NLR cut-off point for MetS was 1.50 with a sensitivity of 74.6% and specificity of 52%. There is a significant relationship between NLR and MetS prevalence in patients with type 2 diabetes mellitus. NLR seems as an independent predictor of MetS in diabetic patients

Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)

Aim Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods The retrospective study was conducted between 8 April and 28 October 2020 in 25 different hospitals from 17 cities. Data were collected from patients' medical records using a standardised form. Clinical and laboratory characteristics and outcomes according to different age groups, gender and body mass index percentiles were compared using multivariate logistic regression analysis. Results The study comprised 101 patients, median age 7 years (interquartile range (IQR) 4.6-9.3); 51 (50.5%) were boys. Reverse-transcriptase polymerase chain reaction (PCR) assay was positive in 21/100 (21%) patients; 62/83 (74.6%) patients had positive serology for SARS-CoV-2. The predominant complaints were fever (100%), fatigue (n = 90, 89.1%), and gastrointestinal symptoms (n = 81, 80.2%). Serum C-reactive protein (in 101 patients, median 165 mg/L; range 112-228), erythrocyte sedimentation rate (73/84, median 53 mm/s; IQR 30-84) and procalcitonin levels (86/89, median 5 mu g/L; IQR 0.58-20.2) were elevated. Thirty-eight patients (37.6%) required admission to intensive care. Kawasaki disease (KD) was diagnosed in 70 (69.3%) patients, 40 of whom had classical KD. Most patients were treated with intravenous immunoglobulin (n = 92, 91%) and glucocorticoids (n = 59, 58.4%). Seven patients (6.9%) died. Conclusion The clinical spectrum of MIS-C is broad, but clinicians should consider MIS-C in the differential diagnosis when persistent fever, fatigue and gastrointestinal symptoms are prominent. Most patients diagnosed with MIS-C were previously healthy. Immunomodulatory treatment and supportive intensive care are important in the management of cases with MIS-C. Glucocorticoids and intravenous immunoglobulins are the most common immunomodulatory treatment options for MIS-C. Prompt diagnosis and prompt treatment are essential for optimal management

Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey

Objectives: The aim of this study is to identify the epidemiological, clinical, and laboratory features of coronavirus disease 2019 (COVID-19) in children