A Rare Cause of Drug-Induced Skin Rash and Eosinophilia

Allopurinol is a well-known drug to treat hyperuricemia in patients with chronic kidney disease, gout, or tumor lysis syndrome. The most common side effects are nausea, vomiting, elevated liver enzyme, pancreatitis, and skin rashes. Drug reaction with eosinophilic and systemic symptoms (DRESS) syndrome is a rare but life-threating complication of allopurinol treatment. Here, we present a 60-year-old male patient admitted with skin rashes, stomatitis, dyspnea, jaundice, elevated liver enzymes, acute renal failure, and eosinophilia, who was diagnosed with allopurinol-related DRESS syndrome

Renal complications of lipodystrophy: A closer look at the natural history of kidney disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/1/cen13732_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/2/cen13732.pd

Study of Structural and Optical Properties of Zinc Oxide Rods Grown on Glasses by Chemical Spray Pyrolysis

We have investigated morphological and optical properties of zinc oxide rods. Highly structured ZnO layers comprising with well-shaped hexagonal rods were prepared by spray pyrolysis deposition of zinc chloride aqueous solutions at ~550∘C. The rods were characterized by X-ray diffraction, scanning electron microscopy, atomic force microscopy, photoluminescence, and ultraviolet and visible absorption spectroscopy measurements. The deposition of the 0.1 mol/L solution at ~550∘C resulted in crystals with a diameter of 400–1000 nm and length of 500–2000 nm. Sharp near-band edge emission peaks, centered at 3844 and 3680 Å, dominated the PL spectra of ZnO at 300 K and 6.2 K, respectively. In addition to this, absorption coefficient was determined by absorption measurement. X-ray diffraction, scanning electron microscopy and atomic force microscopy, results suggest that ZnO rods, prepared by spray pyrolysis, have high crystalline quality. This is desirable in nanotechnology applications

Total intracranial and lateral ventricle volumes measurement in Alzheimer's disease: A methodological study

Measuring of brain and its compartments' sizes from magnetic resonance (MR) images is an effective way to assess disease progression in neurodegenerative disorders, particularly Alzheimer's disease (AD). The objective of this study was to compare total intracranial volume (TIV) and lateral ventricle volume (LVV) in patients with Alzheimer's disease with those in elderly control subjects, and to compare an automated method (automatic lateral ventricle delineation [ALVIN]) and a manual method (Image)). MRI of the brain was performed on 20 patients with Alzheimer's disease and 18 control subjects. The TIV was calculated by a manual method and the LW was calculated by using two methods: an automated and manual method. We found a significant increase in LVVs in Alzheimer's disease patients compared to control subjects, but no difference in TIV between the two groups. A perfect agreement, with 0.989 (0.973-0.996) intraclass correlation coefficient (ICC) and 0.978 (0.946-0.991) concordance correlation coefficient (CCC), was observed between the manual and automatic lateral ventricle measurements in Alzheimer patients. The results revealed that LVV measure has predictive performance in AD. We demonstrated that ALVIN and ImageJ are both effective in determining lateral ventricular volume, providing an objective tool for quantitative assessment of AD. (C) 2016 Elsevier Ltd. All rights reserved

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Tungsten (VI) oxide (WO3) nanoparticles (NPs) are used for many industrial purposes in everyday life. However, their effects on human health have not been sufficiently evaluated. Therefore, the present study was designed to investigate the toxicity potentials of various concentrations (0 to 1000 ppm) of WO3NPs (<100 nm particle size) in cultured primary rat hepatocytes. The results of cell viability assay showed that the higher concentrations of dispersed WO3 NPs (300, 500 and 1000 ppm) caused significant (p<0.05) decreases of cell viability. Also, dose dependent negative alterations were observed in oxidative status and antioxidant capacity levels after the application of WO3 in cultured rat primary hepatocytes. The results of genotoxicity tests revealed that these NPs did not cause significant increases of micronucleated hepatocytes (MNHEPs) but increased 8-oxo-2-deoxyguanosine (8-OH-dG) levels as compared to the control culture

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Tungsten (VI) oxide (WO3) nanoparticles (NPs) are used for many industrial purposes in everyday life. However, their effects on human health have not been sufficiently evaluated. Therefore, the present study was designed to investigate the toxicity potentials of various concentrations (0 to 1000 ppm) of WO3NPs (<100 nm particle size) in cultured primary rat hepatocytes. The results of cell viability assay showed that the higher concentrations of dispersed WO3 NPs (300, 500 and 1000 ppm) caused significant (p<0.05) decreases of cell viability. Also, dose dependent negative alterations were observed in oxidative status and antioxidant capacity levels after the application of WO3 in cultured rat primary hepatocytes. The results of genotoxicity tests revealed that these NPs did not cause significant increases of micronucleated hepatocytes (MNHEPs) but increased 8-oxo-2-deoxyguanosine (8-OH-dG) levels as compared to the control culture

Systemic Onset Juvenile Idiopathic Arthritis: A Single Center Experience

Systemic juvenile idiopathic arthritis (sJIA) presents with prolonged fever and systemic features such as arthritis, rash, lymphadenopathy, hepatosplenomegaly and serositis. In this study, we aimed to evaluate the clinical and laboratory findings, and outcomes of sJIA patients from a tertiary rheumatology center. Between 2010-2017, patients who had been diagnosed with sJIA, participated in the study. The demographics, clinical and laboratory features, and outcomes, were evaluated retrospectively. Seventy- five sJIA (%56 male) patients were enrolled. The mean age at diagnosis was 6,45 +/- 4,80 years. At the time of diagnosis, the most common findings were fever (%100) followed by arthritis (78,7%), and rash (66,2%). Twenty-four percent of the patients present with macrophage activation syndrome (MAS) at the time of diagnosis. Totally, 36% of the patients had at least one MAS attack during the course of the disease. 46% of the patients had polyphasic course while 54% had one attack (26% monophasic, 28% persistant). All of the patients were treated with non-steroid anti-inflammatory drugs (NSAID) and/or corticosteroids at the beginning of the disease. Twenty percent of the patients reached remission with corticosteroid or disease-modifying anti-rheumatic drugs (DMARDs) however the rest of the patients needed at least one biologic agent. Anakinra was the most common first-line biologic treatment choice ( n=45). Fourteen (18,7%) of the patients had polyarticular joint involvement during the disease course, and 5 of them achieved remission with tocilizumab. Systemic JIA is an important disease with high risk of morbidity and mortality. As our center is one of the most important tertiary referral rheumatology centers in the country, we had a high MAS incidence. Eighty percent of the patients achieved remission with a biological agent. Anti-IL1 drugs are mostly preferred for ongoing systemic inflammation. Anti-IL-6 agents are very efficient in patients with a polyarticular course.WoSScopu

Effect of Nb doping on structural, electrical and optical properties of spray deposited SnO2 thin films

Dogan, Seydi/0000-0001-9785-4990; Turgut, Guven/0000-0002-5724-516X; SONMEZ, ERDAL/0000-0002-6241-6314; Ertugrul, Mehmet/0000-0003-1921-7704WOS: 000316648500013Nb doped SnO2 transparent conducting thin films were deposited by spray pyrolysis method. Microstructural, morphological, electrical and optical properties of the films were investigated as a function of niobium (Nb) doping, in the range from 1.0% to 4.0% by atomic percent (with 1.0 at.% step). From XRD patterns the films exhibited a tetragonal cassiterite structure. Although (2 1 1) peak is the most intense peak which is observed for all samples, the (3 0 1) reflection has the highest texture coefficient. the grain size values for (2 1 1) and (3 0 1) peaks were dependent on Nb doping concentration and they varied in the range of 34.99-24.15 nm and 131.4-216.7 nm, respectively. the SEM images of the films showed that the films were made up of grains with polyhedron like shape and that smaller grains were mostly seen in the spaces between polyhedron like grains. Also, SnO2 thin film doped with 2.0 at.% Nb exhibited lowest values of sheet resistance (6.84 Omega) and resistivity (0.62 x 10(-3) Omega cm), beside the highest value of figure of merit (3.4 x 10(-3) Omega(-1)) was obtained for 1.0 at.% Nb doped thin film. the direct optical band gap decreased from 3.98 eV to 3.73 eV with increasing Nb concentration. These results make Nb doped SnO2 films an attractive candidate for many optoelectronic applications. (C) 2013 Elsevier Ltd. All rights reserved.Ataturk UniversityAtaturk University [2012/282, 2012/283]This work was supported by the Ataturk University Research Fund, Project Numbers 2012/282 and 2012/283. One of the authors (G. Turgut) would like to thank to Umit Turgut for technical support