The effects of spatially distributed ionisation sources on the temperature structure of HII region

Spatially resolved studies of star forming regions show that the assumption of spherical geometry is not realistic in most cases, with a major complication posed by the gas being ionised by multiple non-centrally located stars or star clusters. We try to isolate the effects of multiple non-centrally located stars on the temperature and ionisation structure of HII regions, via the construction of 3D photoionisation models using the 3D Monte Carlo photoionisation code MOCASSIN. We find that the true temperature fluctuations due to the stellar distribution (as opposed to the large-scale temperature gradients due to other gas properties) are small in all cases and not a significant cause of error in metallicity studies. Strong emission lines from HII regions are often used to study the metallicity of star-forming regions. We compare integrated emission line spectra from our models and quantify any systematic errors caused by the simplifying assumption of a single, central location for all ionising sources. We find that the dependence of the metallicity indicators on the ionisation parameter causes a clear bias, due to the fact that models with a fully distributed configuration of stars always display lower ionisation parameters than their fully concentrated counterparts. The errors found imply that the geometrical distribution of ionisation sources may partly account for the large scatter in metallicities derived using model-calibrated empirical methods.Comment: 13 pages, 6 figures, Accepted by MNRA

Potato R1 resistance gene confers resistance against Phytophthora infestans in transgenic tomato plants

Tomato is challenged by several pathogens which cause loss of production. One such pathogen is the oomycete Phytophthora infestans which is able to attack all the aerial parts of the plant. Although a wide range of resistance sources are available, genetic control of this disease is not yet successful. Pyramiding R-genes through genetic transformation could be a straightforward way to produce tomato and potato lines carrying durable resistance to P. infestans. In this work the R1 potato gene was transferred into tomato lines. The tomato transgenic lines were analyzed by using q-RT-PCR and progeny segregation to determine the gene copy number. To test the hypothesis that R1 represents a specifically regulated R-gene, transgenic tomato plants were inoculated with P. infestans isolate 88133 and IPO. All the plants containing the R1 gene were resistant to the late blight isolate IPO-0 and susceptible to isolate 88133. These results provide evidence for specific activation of the R1 gene during pathogen challenge. Furthermore, evidence for enhancement of PR-1 gene expression during P. infestans resistance response was obtained

On the gas content of transitional disks: a VLT/X-Shooter study of accretion and winds

Transitional disks (TDs) are thought to be a late evolutionary stage of protoplanetary disks with dust depleted inner regions. The mechanism responsible for this depletion is still under debate. To constrain the models it is mandatory to have a good understanding of the properties of the gas content of the inner disk. Using X-Shooter broad band -UV to NIR- medium resolution spectroscopy we derive the stellar, accretion, and wind properties of a sample of 22 TDs. The analysis of these properties allows us to put strong constraints on the gas content in a region very close to the star (<0.2 AU) which is not accessible with any other observational technique. We fit the spectra with a self-consistent procedure to derive simultaneously SpT,Av,and mass accretion rates (Macc) of the targets. From forbidden emission lines we derive the wind properties of the targets. Comparing our findings to values for cTTs, we find that Macc and wind properties of 80% of the TDs in our sample, which is strongly biased towards strongly accreting objects, are comparable to those of cTTs. Thus, there are (at least) some TDs with Macc compatible with those of cTTs, irrespective of the size of the dust inner hole.Only in 2 cases Macc are much lower, while the wind properties are similar. We do not see any strong trend of Macc with the size of the dust depleted cavity, nor with the presence of a dusty optically thick disk close to the star. In the TDs in our sample there is a gas rich inner disk with density similar to that of cTTs disks. At least for some TDs, the process responsible of the inner disk clearing should allow for a transfer of gas from the outer disk to the inner region. This should proceed at a rate that does not depend on the physical mechanism producing the gap seen in the dust emission and results in a gas density in the inner disk similar to that of unperturbed disks around stars of similar mass.Comment: Accepted on Astronomy & Astrophysics. Abstract shortened to fit arXiv constraint

The interpretation of the field angle dependence of the critical current in defect-engineered superconductors

We apply the vortex path model of critical currents to a comprehensive analysis of contemporary data on defect-engineered superconductors, showing that it provides a consistent and detailed interpretation of the experimental data for a diverse range of materials. We address the question of whether electron mass anisotropy plays a role of any consequence in determining the form of this data and conclude that it does not. By abandoning this false interpretation of the data, we are able to make significant progress in understanding the real origin of the observed behavior. In particular, we are able to explain a number of common features in the data including shoulders at intermediate angles, a uniform response over a wide angular range and the greater discrimination between individual defect populations at higher fields. We also correct several misconceptions including the idea that a peak in the angular dependence of the critical current is a necessary signature of strong correlated pinning, and conversely that the existence of such a peak implies the existence of correlated pinning aligned to the particular direction. The consistency of the vortex path model with the principle of maximum entropy is introduced.Comment: 14 pages, 7 figure

Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition

Olive tree leaves are an abundant source of bioactive compounds with several beneficial effects for human health, including a protective role against many types of cancer. In this study, we investigated the effect of an extract, obtained from olive tree (Olea europaea L.) leaves (OLE), on proliferation, invasion, and epithelial to mesenchymal transition (EMT) on metastatic melanoma, the highly aggressive form of skin cancer and the deadliest diseases. Our results demonstrated that OLE inhibited melanoma cells proliferation through cell cycle arrest and induction of apoptotic cell death. Moreover, OLE suppressed the migration, invasion, and colonies formation of human melanoma cells. Similar to our in vitro findings, we demonstrated that the oral administration of OLE inhibited cutaneous tumor growth and lung metastasis formation in vivo by modulating the expression of EMT related factors. In addition, the anti-proliferative and anti-invasive effects of OLE against melanoma were also related to a simultaneous targeting of mitogen-activated protein kinase and PI3K pathways, both in vitro and in vivo. In conclusion, our findings suggest that OLE has the potential to inhibit the metastatic spread of melanoma cells thanks to its multifaceted mechanistic effects, and may represent a new add-on therapy for the management of metastatic melanoma

Dust entrainment in photoevaporative winds: The impact of X-rays

X-ray- and EUV- (XEUV-) driven photoevaporative winds acting on protoplanetary disks around young T-Tauri stars may crucially impact disk evolution, affecting both gas and dust distributions. We investigate the dust entrainment in XEUV-driven photoevaporative winds and compare our results to existing MHD and EUV-only models. For an X-ray luminosity of $L_X = 2 \cdot 10^{30}\,\mathrm{erg/s}$ emitted by a $M_* = 0.7\,\mathrm{M}_\odot$ star, corresponding to a wind mass-loss rate of $\dot{M}_\mathrm{w} \simeq 2.6 \cdot 10^{-8} \,\mathrm{M_\odot/yr}$, we find dust entrainment for sizes $a_0 \lesssim 11\,\mu$m ($9\,\mu$m) from the inner $25\,$AU ($120\,$AU). This is an enhancement over dust entrainment in less vigorous EUV-driven winds with $\dot{M}_\mathrm{w} \simeq 10^{-10}\,\mathrm{M_\odot/yr}$. Our numerical model also shows deviations of dust grain trajectories from the gas streamlines even for $\mu$m-sized particles. In addition, we find a correlation between the size of the entrained grains and the maximum height they reach in the outflow.Comment: Accepted for publication in A&A. 12+6 pages, 10+9 figure

ILC2s: New Actors in Tumor Immunity

Innate lymphoid cells (ILCs) represent the most recently identified family of innate lymphocytes that act as first responders, maintaining tissue homeostasis and protecting epithelial barriers. In the last few years, group 2 ILCs (ILC2s) have emerged as key regulators in several immunological processes such as asthma and allergy. Whilst ILC2s are currently being evaluated as novel targets for immunotherapy in these diseases, their involvement in tumor immunity has only recently begun to be deciphered. Here, we provide a comprehensive overview of the pleiotropic roles of ILC2s in different tumor settings. Furthermore, we discuss how different therapeutic approaches targeting ILC2s could improve the efficacy of current tumor immunotherapies

High-resolution [OI] line spectral mapping of TW Hya consistent with X-ray driven photoevaporation

Theoretical models indicate that photoevaporative and magnetothermal winds play a crucial role in the evolution and dispersal of protoplanetary disks and affect the formation of planetary systems. However, it is still unclear what wind-driving mechanism is dominant or if both are at work, perhaps at different stages of disk evolution. Recent spatially resolved observations by Fang et al. (2023) of the [OI] 6300 Angstrom spectral line, a common disk wind tracer, in TW Hya revealed that about 80% of the emission is confined to the inner few au of the disk. In this work, we show that state-of-the-art X-ray driven photoevaporation models can reproduce the compact emission and the line profile of the [OI] 6300 Angstrom line. Furthermore, we show that the models also simultaneously reproduce the observed line luminosities and detailed spectral profiles of both the [OI] 6300 Angstrom and the [NeII] 12.8 micron lines. While MHD wind models can also reproduce the compact radial emission of the [OI] 6300 Angstrom line, they fail to match the observed spectral profile of the [OI] 6300 Angstrom line and underestimate the luminosity of the [NeII] 12.8 micron line by a factor of three. We conclude that, while we cannot exclude the presence of an MHD wind component, the bulk of the wind structure of TW Hya is predominantly shaped by a photoevaporative flow.Comment: 7 pages, 4 figures, accepted for publication in Astrophysical Journal Letter