Incorporating climate change into systematic conservation planning

Abstract The principles of systematic conservation planning are now widely used by governments and non-government organizations alike to develop biodiversity conservation plans for countries, states, regions, and ecoregions. Many of the species and ecosystems these plans were designed to conserve are now being affected by climate change, and there is a critical need to incorporate new and complementary approaches into these plans that will aid species and ecosystems in adjusting to potential climate change impacts. We propose five approaches to climate change adaptation that can be integrated into existing or -012-0269-3 new biodiversity conservation plans: (1) conserving the geophysical stage, (2) protecting climatic refugia, (3) enhancing regional connectivity, (4) sustaining ecosystem process and function, and (5) capitalizing on opportunities emerging in response to climate change. We discuss both key assumptions behind each approach and the trade-offs involved in using the approach for conservation planning. We also summarize additional data beyond those typically used in systematic conservation plans required to implement these approaches. A major strength of these approaches is that they are largely robust to the uncertainty in how climate impacts may manifest in any given region. Conserv (2012) 21:1651-1671 DOI 10.1007/s1053

Adaptations of Avian Flu Virus Are a Cause for Concern

We are in the midst of a revolutionary period in the life sciences. Technological capabilities have dramatically expanded, we have a much improved understanding of the complex biology of selected microorganisms, and we have a much improved ability to manipulate microbial genomes. With this has come unprecedented potential for better control of infectious diseases and significant societal benefit. However, there is also a growing risk that the same science will be deliberately misused and that the consequences could be catastrophic. Efforts to describe or define life-sciences research of particular concern have focused on the possibility that knowledge or products derived from such research, or new technologies, could be directly misapplied with a sufficiently broad scope to affect national or global security. Research that might greatly enhance the harm caused by microbial pathogens has been of special concern (1–3). Until now, these efforts have suffered from a lack of specificity and a paucity of concrete examples of “dual use research of concern” (3). Dual use is defined as research that could be used for good or bad purposes. We are now confronted by a potent, real-world example

Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy

Gaucher disease is caused by a deficiency of the lysosomal enzyme glucocerebrosidase (acid βâ glucosidase), with consequent cellular accumulation of glucosylceramide (GLâ 1). The disease is managed by intravenous administrations of recombinant glucocerebrosidase (imiglucerase), although symptomatic patients with mild to moderate type 1 Gaucher disease for whom enzyme replacement therapy (ERT) is not an option may also be treated by substrate reduction therapy (SRT) with miglustat. To determine whether the sequential use of both ERT and SRT may provide additional benefits, we compared the relative pharmacodynamic efficacies of separate and sequential therapies in a murine model of Gaucher disease (D409V/null). As expected, ERT with recombinant glucocerebrosidase was effective in reducing the burden of GLâ 1 storage in the liver, spleen, and lung of 3â monthâ old Gaucher mice. SRT using a novel inhibitor of glucosylceramide synthase (Genzâ 112638) was also effective, albeit to a lesser degree than ERT. Animals administered recombinant glucocerebrosidase and then Genzâ 112638 showed the lowest levels of GLâ 1 in all the visceral organs and a reduced number of Gaucher cells in the liver. This was likely because the additional deployment of SRT following enzyme therapy slowed the rate of reaccumulation of GLâ 1 in the affected organs. Hence, in patients whose disease has been stabilized by intravenously administered recombinant glucocerebrosidase, orally administered SRT with Genzâ 112638 could potentially be used as a convenient maintenance therapy. In patients naïve to treatment, ERT followed by SRT could potentially accelerate clearance of the offending substrate.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147062/1/jimd0281.pd

Can the Professor Come Out To Play? Scholarship, Teaching, and Theories of Play

In January 2008, the authors presented an Open Source program at the National AALS Conference in which they explored the applicability of cognitive/developmental theories of play to our work as scholars and teachers. The authors sang, lectured on theories of play, and involved over 100 law professors in an exercise in which participant groups employed either visual art or music to explain the tort concept of lost chance. In this article, we build upon that program and present an extensive analysis of the literature on childhood play, focusing on those aspects of the type of play which enhances development of creative problem-solving and innovation. We then explore the adult manifestation of this childhood cognitive activity, what John Dewey called a playful attitude, assessing its implications for our scholarship and teaching. As it turns out, these implications are significant, as we detail in the last two sections of the article where we focus on the nexus between play theory and our work as professors of law

Can the Professor Come Out To Play? Scholarship, Teaching, and Theories of Play

In January 2008, the authors presented an Open Source program at the National AALS Conference in which they explored the applicability of cognitive/developmental theories of play to our work as scholars and teachers. The authors sang, lectured on theories of play, and involved over 100 law professors in an exercise in which participant groups employed either visual art or music to explain the tort concept of lost chance. In this article, we build upon that program and present an extensive analysis of the literature on childhood play, focusing on those aspects of the type of play which enhances development of creative problem-solving and innovation. We then explore the adult manifestation of this childhood cognitive activity, what John Dewey called a playful attitude, assessing its implications for our scholarship and teaching. As it turns out, these implications are significant, as we detail in the last two sections of the article where we focus on the nexus between play theory and our work as professors of law

Supporting adaptation decisions through scenario planning: Enabling the effective use of multiple methods

Scenario planning is a technique used to inform decision-making under uncertainty, and is increasingly applied in the field of climate change adaptation and policy. This paper describes applications that combine previously distinct scenario methods in new and innovative ways. It draws on numerous recent independent case studies to illustrate emerging practices, such as far stronger connections between researcher-driven and participatory approaches and cycling between exploratory and normative perspectives. The paper concludes with a call for greater support for, and collaboration among, practitioners with the argument that mixed methods are most effective for decision-making in the context of climate change challenges