4 research outputs found
Mechanisms of deoxynivalenol-induced endocytosis and degradation of tight junction proteins in jejunal IPEC-J2 cells involve selective activation of the MAPK pathways
Spatial control of Cdc42 activation determines cell width in fission yeast
We found 11 wide mutants, seven of which affect the activation of Cdc42. Through epistasis analysis and protein retargeting, we showed that a guanine nucleotide exchange factor and a GTPase-activating protein of Cdc42 each affects cell width independently from different cellular domains. We propose that these proteins set up a spatially restricted gradient of activated Cdc42 that directs cell growth