105 research outputs found
The impact of oronasal breathing on perioral musculature
- Author
- Barros JR
- Berwig LC
- Brandão HV
- Brodie AG
- Brustolin JP
- Bueno SB
- Busanello SAR
- Cai C
- Engelke W
- Felicio CM
- Graber TM
- Hermens HJ
- Hitos S
- Hur MS
- Imbaud TCS
- Knösel M
- Lopes TSP
- Machado PG
- Malhotra S
- Marson A
- Migliorucci RR
- Nagae MH
- Nagae MH
- Oliveira LF
- Oliveira RLB
- Pacheco AB
- Po JMC
- Popoaski C
- Rezende MS
- Rodrigues JA
- Schievano D
- Sinno MD
- Soderberg GL
- Souza DR
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The concept of RNA-assisted protein folding: the role of tRNA
- Author
- A Alexandrov
- A El'skaya
- AE Yonath
- AY Kobitski
- B Rees
- C Woese
- CR Woese
- CR Woese
- DR Engelke
- E Lander
- E Madore
- E Madore
- F Crick
- FHC Crick
- H Lodish
- J Frank
- J Fu
- J Fu
- J Lapointe
- Jan C Biro
- JC Biro
- JC Biro
- JC Biro
- JC Biro
- JC Biro
- JD Watson
- JD Watson
- JS Loehr
- M Helm
- M Sissler
- M Zuker
- MA Jonikas
- MD Roy
- MS VanLoock
- N Kholod
- NR Markham
- NR Markham
- NS Kholod
- P Patkowski
- R Giegé
- R Sathyapriya
- RW Alexander
- RW Holley
- SK Yang
- T Jorgensen
- T Miyazawa
- TA Steitz
- TR Caulfield
- TR Easterwood
- UL Rajbhandary
- V Ramakrishnan
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
We suggest that tRNA actively participates in the transfer of 3D information from mRNA to peptides - in addition to its well-known, "classical" role of translating the 3-letter RNA codes into the one letter protein code. The tRNA molecule displays a series of thermodynamically favored configurations during translation, a movement which places the codon and coded amino acids in proximity to each other and make physical contact between some amino acids and their codons possible. This specific codon-amino acid interaction of some selected amino acids is necessary for the transfer of spatial information from mRNA to coded proteins, and is known as RNA-assisted protein folding
Cellular uptake, cytotoxicity and DNA-binding studies of the novel imidazoacridinone antineoplastic agent C1311
- Author
- A M Burger
- A Skladanowski
- AC Allison
- AM Burger
- AM Burger
- AW McConnaughie
- B Berger
- C Bailly
- CC Cheng
- D Suh
- DR Green
- DS Pilch
- E Augustin
- FG Loontiens
- G Majno
- H Kusnierczyk
- I Haq
- J A Double
- J Konopa
- J Lamb
- J Overgaard
- J Yang
- JA Hickman
- JB Chaires
- JD McGhee
- JR Quintana
- K Engelke
- KM Nicholson
- M Agbandje
- M Beckwith
- M C Bibby
- MC Vega
- MJ Boyer
- RA Firestone
- S Simon
- T C Jenkins
- TC Jenkins
- WM Cholody
- WM Cholody
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
C1311 is a novel therapeutic agent with potent activity against experimental colorectal cancer that has been selected for entry into clinical trial. The compound has previously been shown to have DNA-binding properties and to inhibit the catalytic activity of topoisomerase II. In this study, cellular uptake and mechanisms by which C1311 interacts with DNA and exerts cytotoxic effects in intact colon carcinoma cells were investigated. The HT29 colon cancer cell line was chosen to follow cellular distribution of C1311 over a time course of 24 h at drug concentrations that just inhibited cell proliferation by 50% or 100%. Nuclear uptake of C1311 and co-localization with lysosomal or mitochondrial dyes was examined by fluorescence microscopy and effects on these cellular compartments were determined by measurement of acid phosphatase levels, rhodamine 123 release or DNA-binding behaviour. The strength and mode of DNA binding was established by thermal melting stabilization, direct titration and viscometric studies of host duplex length. The onset of apoptosis was followed using a TUNEL assay and DNA-fragmentation to determine a causal relationship of cell death. Growth inhibition of HT29 cells by C1311 was concomitant with rapid drug accumulation in nuclei and in this context we showed that the compound binds to duplex DNA by intercalation, with likely A/T sequence-preferential binding. Drug uptake was also seen in lysosomes, leading to lysosomal rupture and a marked increase of acid phosphatase activity 8 h after exposure to C1311 concentrations that effect total growth inhibition. Moreover, at these concentrations lysosomal swelling and breakdown preceded apoptosis, which was not evident up to 24 h after exposure to drug. Thus, the lysosomotropic effect of C1311 appears to be a novel feature of this anticancer agent. As it is unlikely that C1311-induced DNA damage alone would be sufficient for cytotoxic activity, lysosomal rupture may be a critical component for therapeutic efficacy. © 1999 Cancer Research Campaig
Small Interfering RNA Targeting M2 Gene Induces Effective and Long Term Inhibition of Influenza A Virus Replication
- Author
- A Garcia-Sastre
- AR Beaton
- AT Das
- B Zheng
- BJ Li
- BJ Zheng
- BJ Zheng
- Bo-Jian Zheng
- D Kinchington
- Ding Xiang Liu
- Dong-Yan Jin
- DR Engelke
- DS An
- E Bernstein
- E Song
- EK Hui
- EM Westerhout
- GI Shapiro
- Guang-Yu Zhao
- H Wang
- H Zhou
- HL Yen
- Hong-Yan Sui
- IN Kandun
- J Degelau
- J Szulc
- JF Arrighi
- JH Beigel
- Jian-Dong Huang
- K Appasani
- K Ungchusak
- Kwok-Yung Yuen
- L Wohlbold
- L Zender
- LV Gubareva
- M Konishi
- M Kumar
- M Scherr
- MD Moore
- MG Katze
- N Doi
- P Houck
- Q Ge
- Q Ge
- RJ Fish
- SM Hammond
- SM Tompkins
- TH Tran
- YC Li
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
RNA interference (RNAi) provides a powerful new means to inhibit viral infection specifically. However, the selection of siRNA-resistant viruses is a major concern in the use of RNAi as antiviral therapeutics. In this study, we conducted a lentiviral vector with a H1-short hairpin RNA (shRNA) expression cassette to deliver small interfering RNAs (siRNAs) into mammalian cells. Using this vector that also expresses enhanced green fluorescence protein (EGFP) as surrogate marker, stable shRNA-expressing cell lines were successfully established and the inhibition efficiencies of rationally designed siRNAs targeting to conserved regions of influenza A virus genome were assessed. The results showed that a siRNA targeting influenza M2 gene (siM2) potently inhibited viral replication. The siM2 was not only effective for H1N1 virus but also for highly pathogenic avian influenza virus H5N1. In addition to its M2 inhibition, the siM2 also inhibited NP mRNA accumulation and protein expression. A long term inhibition effect of the siM2 was demonstrated and the emergence of siRNA-resistant mutants in influenza quasispecies was not observed. Taken together, our study suggested that M2 gene might be an optimal RNAi target for antiviral therapy. These findings provide useful information for the development of RNAi-based prophylaxis and therapy for human influenza virus infection
Methanotrophy, Methylotrophy, the Human Body and Disease
- Author
- A Pino
- AL Truant
- AP Lauder
- AP Wood
- AP Wood
- B Austin
- C Klaessen
- C Turner
- C Xuan
- C-C Lai
- C-H Lee
- CJ Cold
- CR Kleiveland
- DD Bills
- DE Waturangi
- DP Kelly
- DR Hoffman
- E Borodina
- E Borodina
- E Engel
- E Sanhueza
- E Smet
- E Yabuuchi
- F Bellesia
- FL Suarez
- G Leonardos
- G Ljunggren
- G Preti
- GA McFeters
- GL Gilardi
- H Amiri
- H Dalton
- H Ito
- H Schäfer
- H Wang
- H Wolrath
- HR Langenhove van
- HR Yadzi
- HY Weon
- J Barbeau
- J Bystedt
- J Kovaleva
- J Nešvera
- J Tonzetich
- JG Moore
- JJ Schellenberg
- JM Leach
- JO Falkinham 3rd
- Julian C. Hong
- K Tamura
- KY Kim
- L Tymczyna
- LA Kulakov
- LD Lawson
- M Gallagher
- M Musilova
- M Shirasu
- MA Brown
- MJR Gilchrist
- MM Uy
- N Castaño-Rodriguez
- P Debye
- P Green
- PC Rutherford
- PH Warnke
- PR Usha
- R Boden
- R Boden
- RC Edgar
- S Indrelid
- S Kumar
- S Weyers
- SC Mitchell
- SJ Salter
- SM Smith
- T Talou
- TE Christoffersen
- TG Florin
- TJ Smith
- TM Carvajal
- UF Engelke
- V Anesti
- V Anesti
- V Gallego
- V Gallego
- V Gallego
- W Chen
- W Lindinger
- W-L Hung
- Y Kato
- Z Aslam
- Publication venue
- Cham, Switzerland
- Publication date
- 30/11/2018
- Field of study
Methylotrophic Bacteria use one-carbon (C1) compounds as their carbon source. They have been known to be associated to the human body for almost 20 years as part of the normal flora and were identified as pathogens in the early 1990s in end-stage HIV patients and chemotherapy patients. In this chapter, I look at C1 compounds in the human body and exposure from the environment and then consider Methylobacterium spp. and Methylorubrum spp. in terms of infections, its role in breast and bowel cancers; Methylococcus capsulatus and its role in inflammatory bowel disease, and Brevibacterium casei and Hyphomicrobium sulfonivorans as part of the normal human flora. I also consider the abundance of methylotrophs from the Actinobacteria being identified in human studies and the potential bias of the ionic strength of culture media and the needs for future work. Within the scope of future work, I consider the need for the urgent assessment of the pathogenic, oncogenic, mutagenic and teratogenic potential of Methylobacterium spp. and Methylorubrum spp. and the need to handle them at higher containment levels until more data are available
Interferometric Observations of Rapidly Rotating Stars
- Author
- A Claret
- A Claret
- A Claret
- A Claret
- A Domiciano de Souza
- A Domiciano de Souza
- A Domiciano de Souza
- A Glindemann
- A Reiners
- A Slettebak
- A Slettebak
- A Slettebak
- A Slettebak
- A Slettebak
- A Slettebak
- AA Michelson
- AA Orlov
- AC Carciofi
- AF Boden
- AS Eddington
- AS Eddington
- B Smalley
- B Smalley
- BL Rachford
- C Aerts
- C Han
- C Haniff
- C Haniff
- C Westgate
- C Westgate
- C Westgate
- CH Townes
- CT Elvey
- CW Engelke
- D Herbison-Evans
- DB McLaughlin
- DF Gray
- DM Peterson
- DM Peterson
- DO Pease
- DR Ciardi
- DR Gies
- E Roche
- ER Wilson
- F Baron
- F Espinosa Lara
- F Royer
- F Schlesinger
- F Schlesinger
- G Hill
- G Meynet
- G Shajn
- G Weigelt
- Gerard T. van Belle
- GH Rieke
- GT Belle van
- GT Belle van
- GT Belle van
- GT Belle van
- GW Collins II
- GW Collins II
- GW Collins II
- GW Collins II
- GW Collins II
- H Zeipel von
- H Zeipel von
- HA Abt
- HA Abt
- HA McAlister
- HB Snodgrass
- HC Vogel
- HH Aumann
- HL Johnson
- IJ Sackmann
- J Christensen-Dalsgaard
- J Robrade
- J Yoon
- J Yoon
- J Zorec
- J-L Tassoul
- J-L Tassoul
- J-P Berger
- J-P Rozelot
- JD Monnier
- JD Monnier
- JD Monnier
- JD Monnier
- JD Monnier
- JE Neff
- JH Rhee
- JM Porter
- JN Winn
- JP Aufdenberg
- JP Aufdenberg
- JP Harrington
- JR Kuhn
- JT Armstrong
- JW Barnes
- JW Goodman
- KB MacGregor
- L Iorio
- LB Lucy
- M Asplund
- M Gerbaldi
- M Rieutord
- M Zhao
- M Zhao
- MAC Perryman
- MJ Ireland
- MM Colavita
- MS Cunha
- N Ohishi
- NJ Rattenbury
- O Absil
- O Struve
- P Brunet
- P Kervella
- P Kervella
- P Kervella
- PL Bernacca
- PR Lawson
- R Connon Smith
- R Hanbury Brown
- R Hanbury Brown
- R Narayan
- R Temple
- RA Rossiter
- RG Deupree
- RG Petrov
- RL Akeson
- RL Baron
- RO Gray
- RO Gray
- RO Gray
- S Chandrasekhar
- S Drake
- S Hinkley
- S Jackson
- S Kanaan
- S Lefebvre
- S Lefebvre
- S Rappaport
- S Seager
- S Yi
- SM Lawler
- SP Owocki
- SR Cranmer
- TA Brummelaar ten
- V Straizys
- V Trimble
- VR Khalack
- W Cotton
- W Huang
- WDW Abney
- X Che
- Y Takeda
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Optical interferometry provides us with a unique opportunity to improve our
understanding of stellar structure and evolution. Through direct observation of
rotationally distorted photospheres at sub-milliarcsecond scales, we are now
able to characterize latitude dependencies of stellar radius, temperature
structure, and even energy transport. These detailed new views of stars are
leading to revised thinking in a broad array of associated topics, such as
spectroscopy, stellar evolution, and exoplanet detection. As newly advanced
techniques and instrumentation mature, this topic in astronomy is poised to
greatly expand in depth and influence.Comment: Accepted for publication in A&AR
Comment on Boyer’s multiattentional method
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recommended from our members
Search for long-lived heavy neutral leptons with lepton flavour conserving or violating decays to a jet and a charged lepton
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdalla H
- Abdullin S
- Abreu A
- Abu Zeid S
- Acharya H
- Acharya S
- Acosta D
- Adam W
- Adamidis K
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Aebi D
- Afanasiev S
- Agapitos A
- Agarwal G
- Agram J-L
- Aguilar-Benitez M
- Agyel D
- Ahmad A
- Ahmad M
- Ahmed A
- Aimè C
- Ajmal S
- Akchurin N
- Akgun B
- Akpinar A
- Al Kadhim A
- Albrecht A
- Albrecht S
- Albrow M
- Alcaraz Maestre J
- Alcerro Alcerro LF
- Aldaya Martin M
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allmond B
- Ally D
- Almond J
- Alpana A
- Alsufyani B
- Alvarez Gonzalez B
- Alverson G
- Alves Gallo Pereira M
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrozas M
- Ameen MM
- Amendola C
- Amoroso S
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Anguiano J
- Antchev G
- Anthony D
- Antonello M
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Araujo M
- Aravind A
- Arcaro D
- Arcidiacono R
- Ardino R
- Argiro S
- Arneodo M
- Aruta C
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Assiouras P
- Assran Y
- Atakisi IO
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydilek O
- Azarkin M
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babbar J
- Bacchetta N
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagaturia I
- Bagliesi G
- Bahinipati S
- Bainbridge R
- Bak G
- Bakas G
- Bakhshiansohi H
- Bakshi AS
- Bala A
- Baldenegro Barrera C
- Ball AH
- Bam B
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Bansal S
- Baradia S
- Barbagli G
- Barberis E
- Barbosa Trujillo DA
- Bardelli G
- Bargassa P
- Baringer P
- Barman S
- Barnes VE
- Barney D
- Barria P
- Barroso Ferreira Filho M
- Bartek R
- Bartosik N
- Bartók M
- Barzdukas A
- Basnet A
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Bautista I
- Baxter S
- Bayatmakou M
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bedoya CF
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Beirão Da Cruz E Silva C
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belvedere A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Benitez JF
- Bennett C
- Benussi L
- Bergauer T
- Beri SB
- Bermúdez Martínez A
- Bernardes CA
- Berry D
- Berryhill J
- Besancon M
- Bestintzanos I
- Bethani A
- Bevilacqua T
- Beyrouthy T
- Bhardwaj A
- Bharthuar S
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bhowmik D
- Bhowmik S
- Bhyun JH
- Bialkowska H
- Bianchini L
- Bianco M
- Bianco S
- Biino C
- Bilei GM
- Bilin B
- Bin Anuar AA
- Bin Norjoharuddeen N
- Bisello D
- Black K
- Blanco Fernández S
- Blancon B
- Blekman F
- Blend D
- Blinov V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boldrini G
- Boletti A
- Bols ES
- Bonacorsi D
- Bonanomi M
- Bonilla J
- Boos E
- Boran F
- Borca C
- Borgonovi L
- Bornheim A
- Borras K
- Borshch V
- Bortignon P
- Bose T
- Bossini E
- Botta C
- Botta V
- Bouchamaoui H
- Boudoul G
- Bouhali O
- Bourilkov D
- Bower S
- Boyaryntsev A
- Bozzo M
- Bragagnolo A
- Braghieri A
- Brainerd C
- Brandao Malbouisson H
- Branson JG
- Breedon R
- Brennan L
- Brew C
- Bright-Thonney S
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brochero Cifuentes JA
- Brom J-M
- Brommer S
- Brondolin E
- Brooke JJ
- Brown CE
- Brown RM
- Bruno G
- Bruschini D
- Bryant P
- Brzhechko D
- Brücken E
- Bubanja I
- Bucci R
- Buchmuller O
- Buchot Perraguin A
- Budkouski D
- Bueghly J
- Bundock A
- Bunichev V
- Bunkowski K
- Buontempo S
- Burkart M
- Burkett K
- Bury F
- Busson P
- Busza W
- Butalla S
- Butler JN
- Butler PH
- Butz E
- Bylsma B
- Bärtschi P
- Cabrera A
- Cabrillo IJ
- Cacchio V
- Cadamuro L
- Cagnotta A
- Caillol C
- Cakir A
- Calandri A
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Calligaris L
- Calzaferri S
- Camaiani B
- Caminada L
- Campagnari C
- Campana M
- Campanini R
- Campbell A
- Camporesi T
- Candelise V
- Canelli MF
- Canepa A
- Cankocak K
- Capiluppi P
- Cappati A
- Caputo C
- Caraway B
- Cardini A
- Cardwell B
- Carlin R
- Carnahan T
- Carnevali F
- Carrera Jarrin E
- Carrigan M
- Carrillo Montoya CA
- Cartiglia N
- Carvalho W
- Casarsa M
- Cassese A
- Castaldi R
- Castaneda Hernandez A
- Castells S
- Castilla-Valdez H
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Cazzaniga C
- Ceard L
- Ceccarelli R
- Cepaitis V
- Cepeda M
- Cerati GB
- Cerci S
- Cerminara G
- Cerrada M
- Cerri O
- Cetorelli F
- Chabert EC
- Chadeeva M
- Chahal GS
- Chandra S
- Chang P
- Chanon N
- Chao Y
- Charlot C
- Chatagnon P
- Chatterjee RM
- Chatterjee S
- Chatterjee S
- Chatzistavrou T
- Chaudhary G
- Chauhan S
- Chawla R
- Checchia P
- Chekhovsky V
- Chen GM
- Chen HS
- Chen KF
- Chen M
- Chen PS
- Chen X
- Chen Y
- Chen YM
- Chen Z
- Chen ZG
- Chenarani S
- Cheng C
- Cheng T
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung HWK
- Chhetri A
- Chiarito B
- Chinellato J
- Chistov R
- Chitroda BK
- Chiusi M
- Chlebana F
- Choi J
- Choi J
- Choi M
- Choi S
- Chou JP
- Choudhary BC
- Christoforou K
- Chudasama R
- Chwalek T
- Ciangottini D
- Ciocci MA
- Cipriani M
- Citron M
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clement E
- Clerbaux B
- Cockerill DJA
- Coelho E
- Colaleo A
- Coldham K
- Cole JE
- Colino N
- Collard C
- Colling D
- Colombina F
- Connor P
- Consuegra Rodríguez S
- Contardo D
- Conway J
- Cooke C
- Cooper SI
- Cooperstein S
- Corcodilos L
- Cormier K
- Correia Silva G
- Cosby C
- Cossutti F
- Costa M
- Costa S
- Coubez X
- Couderc F
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Cranshaw DJ
- Creanza D
- Cremaldi LM
- Cremonesi M
- Crossman B
- Crotte Ledesma H
- Csanád M
- Csorgo T
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cummings G
- Cunqueiro Mendez L
- Cussans D
- Cutts D
- Czellar S
- Da Costa EM
- Da Molin G
- Da Silveira GG
- Dabrowski A
- Dallavalle GM
- Damanakis K
- Damas F
- Damgov J
- Dancu JS
- Dansana S
- Darwish MR
- Das A
- Das AK
- Das I
- Das P
- Das S
- Daskalakis G
- Dasu S
- Datta A
- Datta K
- Dauncey P
- David A
- Davies G
- Davies J
- Davignon O
- Davis J
- de Barbaro P
- De Bruyn I
- De Coen M
- De Cosa A
- De Filippis N
- De Guio F
- De Iorio A
- De Jesus Damiao D
- De La Cruz B
- De La Cruz-Burelo E
- De Lentdecker G
- De Leo K
- De Moor A
- De Palma M
- De Roeck A
- De Silva M
- de Trocóniz JF
- De Wit A
- Defranchis MM
- Deile M
- Dejardin M
- Del Re D
- Delaere C
- Delannoy AG
- Delcourt M
- Delgado Peris A
- Della Negra M
- Della Ricca G
- Dell’Orso R
- Demaria N
- Demina R
- Demiragli Z
- Demiroglu ZS
- Denegri D
- Depasse P
- Dermenev A
- Dervan J
- Dewanjee RK
- Dezoort G
- Dharmaratna WGD
- Dhingra N
- Di Florio A
- Di Marco E
- Di Mattia A
- Diaz D
- Dickinson J
- Diekmann S
- Diemoz M
- Dierlamm A
- Dilsiz K
- Dimitrov A
- Dimova T
- Dinardo ME
- Dini P
- Diotalevi T
- Dissertori G
- Dittmann J
- Dittmar M
- Dittmer S
- Dobson M
- Dobur D
- Dodonova A
- Dogra S
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 19/03/2024
- Field of study
A preprint version of the article is available at arXiv:2312.07484v3 [hep-ex], https://arxiv.org/abs/2312.07484 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-013 (CMS Public Pages)A search for long-lived heavy neutral leptons (HNLs) is presented, which considers the hadronic final state and coupling scenarios involving all three lepton generations in the 2-20 GeV HNL mass range for the first time. Events comprising two leptons (electrons or muons) and jets are analyzed in a data sample of proton-proton collisions, recorded with the CMS experiment at the CERN LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb−1. A novel jet tagger, based on a deep neural network, has been developed to identify jets from an HNL decay using various features of the jet and its constituent particles. The network output can be used as a powerful discriminating tool to probe a broad range of HNL lifetimes and masses. Contributions from background processes are determined from data. No excess of events in data over the expected background is observed. Upper limits on the HNL production cross section are derived as functions of the HNL mass and the three coupling strengths VℓN to each lepton generation ℓ and presented as exclusion limits in the coupling-mass plane, as lower limits on the HNL lifetime, and on the HNL mass. In this search, the most stringent limit on the coupling strength is obtained for pure muon coupling scenarios; values of |VμN|2 > 5 (4) × 10−7 are excluded for Dirac (Majorana) HNLs with a mass of 10 GeV at a confidence level of 95% that correspond to proper decay lengths of 17 (10) mm.SCOAP3
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Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at √s = 13 TeV
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- Zuolo D
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- Publication venue
- Elsevier
- Publication date
- 02/02/2024
- Field of study
Data availability:
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in “CMS data preservation, re-use and open access policy” available online at: https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2 .A preprint of this article is available online at arXiv:2311.03261v2 [hep-ex] https://arxiv.org/abs/2311.03261v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-010 (CMS Public Pages)A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp → tH/A → tt¯c and pp → tH/A → tt¯u processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb−1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.SCOAP3
Recommended from our members
Evidence for tWZ production in proton-proton collisions at √s=13 TeV in multilepton final states
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- Zehetner P
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- Zghiche A
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- Publication venue
- Elsevier BV
- Publication date
- 21/06/2024
- Field of study
Data availability - https://www.sciencedirect.com/science/article/pii/S0370269324003733?via%3Dihub#dav0001 [Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open access policy (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2)]The first evidence for the standard model production of a top quark in association with a W boson and a Z boson is reported. The measurement is performed in multilepton final states, where the Z boson is reconstructed via its decays to electron or muon pairs. At least one W boson, associated or from top quark decay, decays leptonically, too. The analysed data were recorded by the CMS experiment at the CERN LHC in 2016–2018 in proton-proton collisions at √s=13 TeV, and correspond to an integrated luminosity of 138 fb−1. The measured cross section is 354±54(stat)±95(syst) fb, and corresponds to a statistical significance of 3.4 standard deviations.SCOAP
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