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[Control of liver carbohydrate and lipid metabolism by cell volume.]

Certain amino acids such as glutamine and proline stimulate liver glycogen synthesis and lipogenesis. This implies cell swelling and leads to the activation of glycogen synthase and acetyl-CoA carboxylase by a common mechanism. This mechanism results from the cell response to swelling and involves a fall in intracellular concentration of chloride ions and an increase in intracellular concentration of glutamate and aspartate. These ions indeed regulate the protein phosphatases that activate glycogen synthase and acetyl-CoA carboxylase

Centre C.N.R.S.-I.N.S.E.R.M. de pharmacologie-endocrinologie. Rapport d'activite 1982

SIGLECNRS-CDST / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine

Spontaneous cortisol-secreting adrenocortical tumours in pet dogs are an attractive animal model for their human counterparts. Adrenal morphology and function are similar in dogs and humans, and adrenocortical tumours have comparable clinical and pathological characteristics. Their relatively high incidence in pet dogs represents a potential source of adrenocortical tumour tissue to facilitate research. The molecular characteristics of canine cortisol-secreting adrenocortical tumours suggest that they will be useful for the study of angiogenesis, the cAMP/protein kinase A pathway, and the role of Steroidogenic Factor-1 in adrenal tumourigenesis. Pet dogs with spontaneous cortisol-secreting adrenocortical tumours may also be useful in clinical testing of new drugs and in investigating the molecular background of adrenocortical tumours

MARC-ANDRÉ HÉBERT

à la Faculté des études supérieures de l'Université Laval dans le cadre du programme de maîtrise en Physiologie-Endocrinologie pour l'obtention du grade de Maîtrise ès sciences (M.Sc.