Experience with a Workflow using MS Word and a DOCX to TEI Converter

In this contribution we summarize our experience in edition projects with the conversion from DOCX files to TEI-XML files. A tool called DOCX2TEI, developed in our team, is capable of transforming DOCX files automatically to TEI files without the need of manual post-processing of conversion results by editors. However, for this to function properly pertinent programming knowledge is required to make the necessary adaptations on DOCX2TEI. We compare DOCX2TEI with other tools capable of producing TEI files out of DOCX files. At the end of the paper we will present the lesson learned from deploying and using this tool

Kommentierte Online-Edition des Gesamtbriefwechsels Ludwig von Ficker

Projektberich

Vom Naturalismus zur Nervenkunst. Bemerkungen zur frühen literarischen Produktion Ludwig von Fickers

Der Beitrag geht der Frage nach, auf welche Weise die frühe literarische Produktion des Innsbrucker Publizisten Ludwig von Ficker (1880‒1967) vom Naturalismus bzw. der Moderne beeinflusst war. Ficker veröffentlichte um die Jahrhundertwende zwei Dramen, einen Gedichtband sowie einzelne kurze Texte in der regionalen Presse, konnte aber erst mit seinem publizistischen Hauptwerk, der Kunst- und Kulturzeitschrift „Der Brenner“ (1910–1954), reüssieren. Für die Zeit bis zum Anbruch des „expressionistischen Jahrzehnts“ werden die vielfältigen Einflussfaktoren nachgezeichnet, die auf den jungen Dichter wirkten, sein Schaffen kontextualisiert sowie sein Weg von einer an der Provinzkunst angelehnten Literatur hin zu einem breiteren Kulturbegriff dargestellt.L’article s’intéresse à la question de savoir dans quelle mesure la première production littéraire du publiciste d’Innsbruck Ludwig von Ficker (1880-1967) a été influencée par le naturalisme, voire par la modernité. Au tournant du XIXe au XXe siècle, Ficker a publié deux drames, un recueil de poèmes ainsi que quelques textes courts dans la presse régionale. C’est cependant seulement avec son œuvre majeure, la revue culturelle Der Brenner (1910-1954), qu’il a pu s’établir dans le milieu littéraire et culturel. L’étude retrace les multiples facteurs qui ont influencé le jeune poète jusqu’à l’arrivée de la « décennie expressionniste », elle contextualise son œuvre et dessine le chemin qui l’a mené d’une littérature adossée à l’art régional à un concept plus large de la culture.This article explores the ways in which the early literary production of the Innsbruck publicist Ludwig von Ficker (1880–1967) was influenced by Naturalism and Modernism. Around the turn of the twentieth century Ficker published two dramas, one book of poems, as well as individual short texts in the local press, but his success came from his main journalistic work, the art and literary magazine Der Brenner (1910 to 1954). This article covers the manifold factors that influenced the young writer and poet during the time period up to the advent of the “expressionist decade”; his work is contextualised and his path traced from a literature that relied upon provincial art to a much broader understanding of culture

A modified indicator-based evolutionary algorithm (mIBEA)

Multi-objective evolutionary algorithms (MOEAs) based on the concept of Pareto-dominance have been successfully applied to many real-world optimisation problems. Recently, research interest has shifted towards indicator-based methods to guide the search process towards a good set of trade-off solutions. One commonly used approach of this nature is the indicator-based evolutionary algorithm (IBEA). In this study, we highlight the solution distribution issues within IBEA and propose a modification of the original approach by embedding an additional Pareto-dominance based component for selection. The improved performance of the proposed modified IBEA (mIBEA) is empirically demonstrated on the well-known DTLZ set of benchmark functions. Our results show that mIBEA achieves comparable or better hypervolume indicator values and epsilon approximation values in the vast majority of our cases (13 out of 14 under the same default settings) on DTLZ1-7. The modification also results in an over 8-fold speed-up for larger populations

Independent Risk Factors for Fast-Track Failure Using a Predefined Fast-Track Protocol in Preselected Cardiac Surgery Patients

ObjectisvesThe purpose of this study was to identify the independent risk factors for fast-track failure (FTF) in cardiac surgery patients.DesignA retrospective analysis.SettingA university-affiliated heart center.ParticipantsIn a 2-year period, 1,704 consecutive preselected patients undergoing elective cardiac surgery were treated according to the local fast-track protocol in the postanesthetic care unit (PACU), bypassing the intensive care unit (ICU).Measurements and ResultsIndependent risk factors for FTF in the univariate regression analysis were tested in a multivariate regression analysis. FTF was defined as any transfer of the preselected patient to the ICU. FTF was primary when the patient was transferred directly from the postanesthetic care unit to the ICU and secondary when the patient was transferred from the intermediate care unit or ward to the ICU. FTF rate was 11.6% for primary and 5.6% for secondary FTF. In the multivariate regression analysis, age>70 years, female sex, prolonged surgery, and prolonged cross-clamp time could be defined as independent risk factors for FTF.ConclusionsIn a preselected patient population, fast-track treatment could be done with a low FTF rate. Independent risk factors for FTF are age, female sex, prolonged surgery, and prolonged cross-clamp time

RAPTOR - Room Adaptive Precisely Topologically Orienting Robot

Die Projektgruppe 524, auch RAPTOR (Room Adaptive Precisely Topologically Orienting Robot) genannt, entwickelt mit dem c’t Bot als Grundlage, einen Staubsaugerroboter ohne Saugmechanismus. Motiviert von den Unzulänglichkeiten bestehender Roboter strebt die Projektgruppe einige Verbesserungen, siehe Abschnitt 1.1 auf dieser Seite, an. Auf das Ziel und die Vorgehensweise wird in den Abschnitten 1.2 und 1.3 näher eingegangen

Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs

Small nucleolar RNAs (snoRNAs) and microRNAs are two classes of non-protein-coding RNAs with distinct functions in RNA modification or post-transcriptional gene silencing. In this study, we introduce novel insights to RNA-induced gene activity adjustments in human cells by identifying numerous snoRNA-derived molecules with miRNA-like function, including H/ACA box snoRNAs and C/D box snoRNAs. In particular, we demonstrate that several C/D box snoRNAs give rise to gene regulatory RNAs, named sno-miRNAs here. Our data are complementing the increasing number of studies in the field of small RNAs with regulatory functions. In massively deep sequencing of small RNA fractions we identified high copy numbers of sub-sequences from >30 snoRNAs with lengths of ≥18 nt. RNA secondary structure prediction indicated for a majority of candidates a location in predicted stem regions. Experimental analysis revealed efficient gene silencing for 11 box C/D sno-miRNAs, indicating cytoplasmic processing and recruitment to the RNA silencing machinery. Assays in four different human cell lines indicated variations in both the snoRNA levels and their processing to active sno-miRNAs. In addition we show that box D elements are predominantly flanking at least one of the sno-miRNA strands, while the box C element locates within the sequence of the sno-miRNA guide strand

MicroRNA-96 Directly Inhibits γ-Globin Expression in Human Erythropoiesis

Fetal hemoglobin, HbF (α2γ2), is the main hemoglobin synthesized up to birth, but it subsequently declines and adult hemoglobin, HbA (α2β2), becomes predominant. Several studies have indicated that expression of the HbF subunit γ-globin might be regulated post-transcriptionally. This could be confered by ∼22-nucleotide long microRNAs that associate with argonaute proteins to specifically target γ-globin mRNAs and inhibit protein expression. Indeed, applying immunopurifications, we found that γ-globin mRNA was associated with argonaute 2 isolated from reticulocytes that contain low levels of HbF (<1%), whereas association was significantly lower in reticulocytes with high levels of HbF (90%). Comparing microRNA expression in reticulocytes from cord blood and adult blood, we identified several miRNAs that were preferentially expressed in adults, among them miRNA-96. The overexpression of microRNA-96 in human ex vivo erythropoiesis decreased γ-globin expression by 50%, whereas the knock-down of endogenous microRNA-96 increased γ-globin expression by 20%. Moreover, luciferase reporter assays showed that microRNA-96 negatively regulates expression of γ-globin in HEK293 cells, which depends on a seedless but highly complementary target site located within the coding sequence of γ-globin. Based on these results we conclude that microRNA-96 directly suppresses γ-globin expression and thus contributes to HbF regulation

Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds

Peer reviewe