Psöriasisde Tamamlayıcı Ve Alternatif Tıp Yöntemleri Kullanımı Ve Beslenmeyle Olan İlişki: Bir Anket Çalışması

Amaç: Bu çalışmayla dermatoloji polikliniğimize başvuran psöriasis hastalarının Tamamlayıcı ve Alternatif Tıp TAT yöntemleri hakkındaki bilgi ve yaklaşımları ile psöriasis hastalığının besinlerle olabilecek ilişkisini değerlendirmeyi amaçladık.Gereç ve Yöntem: Çalışmamız Mayıs 2018-Temmuz 2018 tarihleri arasında dermatoloji polikliniğine psöriasis nedeniyle başvuran 111 hasta ile anket çalışması olarak planlandı. Anket soruları hastalarla poliklinik ortamında yüz yüze soru-cevap şeklinde uygulandı.Bulgular: Çalışmamıza gönüllü olarak katılan 111 hastanın 58'i %52,3 erkek, 53'ü %47,7 kadın idi. Ankete katılanların 59’u %53,2 herhangi bir TAT yöntemi kullanmadığını,52’si %46,8 ise kullandığını bildirdi. Kullanan ve kullanmayanlar arasında cinsiyet, eğitim düzeyi, hastalık süresi, yaşadığı yer açısından istatistiksel olarak anlamlı farklılık saptanmadı. Ancak yaş olarak kullananların yaş ortalamasının kullanmayan gruptan anlamlı olarak düşük olduğu bulundu t 109 =2.484; p=0.01

Relationship of Serum Trimethylamine N-Oxide Levels With Carotid Intima-Media Thickness and Disease Activity in Psoriasis Patients

Introduction:  Psoriasis is an inflammatory disease that can cause cardiovascular comorbidities. Some recent studies have indicated that impaired gut microbiota and metabolites may be associated with inflammatory diseases. Objectives: In this study, the relationship between serum trimethylamine n-oxide (TMAO, a gut bacterial metabolite) level and carotid intima-media thickness (CIMT) and disease severity in psoriasis patients was investigated. Methods: Age- and gender-matched 73 patients and 72 healthy controls were included in the study. In both groups serum trimethylamine n-oxide(TMAO), oxidized low- density lipoprotein (ox-LDL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride, total cholesterol, high-sensitivity C-reactive protein (hs-CRP), creatinine, aspartate aminotransferase (AST) and alanine aminotransferase(ALT) levels were recorded and the carotid intima-media thickness (CIMT) was measured by B-mode ultrasonography by a cardiologist.   Results: TMAO, hs-CRP, oxidized-LDL, triglyceride and CIMT levels were statistically higher in the patient group. HDL levels were statistically higher in the control group. There was no significant difference between the two groups in terms of total cholesterol and LDL-C levels. In partial correlation analyzes in the patient group, positive correlations were observed between TMAO and CIMT, LDL-C and total cholesterol levels. Linear regression analysis showed that TMAO levels positively predicted CIMT levels. Conclusions: This study confirmed that psoriasis is a risk factor for the development of cardiovascular disease and that elevated serum TMAO levels in these patients indicate the presence of intestinal dysbiosis. Furthermore, TMAO levels were found to be a predictor of the risk of developing cardiovascular disease in psoriasis patients

Turkey Urticaria Diagnosis and Treatment Guide based; Distribution of Chronic Urticaria Patients Treated in Our Clinic According to Step Therapy

Aim: Chronic urticaria is a condition that requires long-term treatment. In recent years, many countries have created their own guides to evaluate urticaria diagnosis and treatment approaches in an algorithm. In this study, we aimed to evaluate the distribution of patients with chronic urticaria treated in our clinic according to the treatment algorithm the "Turkey Urticaria Diagnosis and Treatment Guide" Material and Method: The files of the patients who applied to the Department of Dermatology and Venereal Diseases at Selcuk University and were followed up and treated with the diagnosis of chronic urticaria were investigated. Results: A total of 102 chronic urticaria patients without angioedema were included in the study. According to this guide, 17.6% of patients responded with standard dose antihistamine therapy, while the antihistamine dose given in 15.7% of patients was increased. The antihistamine treatment of 5.7% of patients was replaced by a different group of antihistamines at the same dose as the previous one. 52% of patients responded to omalizumab 300 mg / subcutaneous treatment every 28 days. However, 7.8% of the patients received omalizumab treatment every 14 days or cyclosporine treatment was required to be added to omalizumab treatment. Response to other treatments other than standard treatments was received in 1% of patients. Conclusion: We believe that our study will facilitate predicting the treatment responses of patients in clinical practice by shedding light on the distribution of chronic urticaria patients according to the treatment algorithm