Twin Ion Engine Demonstration for Small Spacecraft Applications

Two iodine-fueled, second-generation (Gen-2) “BIT-3” gridded RF ion propulsion systems were successfully demonstrated in proximity. The test units feature a host of upgrades from the flight models delivered to Lunar IceCube and LunaH-Map 6U Cube missions onboard NASA’s SLS Artemis 1. Each Gen-2 BIT-3 system is capable of 1.1 mN thrust, 2,150 sec specific impulse and 31.7 kN-sec total impulse, at 75W maximum power input. The twin engines, separated by a mere 6.5 cm, successfully performed simultaneous startup, sequential startup, and throttling, all without noticeable plasma interference. Onboard telemetry confirms that both thruster and cathode pairs operated nominally, and both ion plumes were stable and properly neutralized by the cathodes in all scenarios. This result should give confidence to microsatellite developers who are looking to fulfill propulsion requirements by multiplexing the BIT-3 - a compact, high-TRL, cost-effective, and readily available propulsion module

Verifying constant-time implementations

The constant-time programming discipline is an effective countermeasure against timing attacks, which can lead to complete breaks of otherwise secure systems. However, adhering to constant-time programming is hard on its own, and extremely hard under additional efficiency and legacy constraints. This makes automated verification of constant-time code an essential component for building secure software. We propose a novel approach for verifying constant- time security of real-world code. Our approach is able to validate implementations that locally and intentionally violate the constant-time policy, when such violations are benign and leak no more information than the pub- lic outputs of the computation. Such implementations, which are used in cryptographic libraries to obtain impor- tant speedups or to comply with legacy APIs, would be declared insecure by all prior solutions. We implement our approach in a publicly available, cross-platform, and fully automated prototype, ct-verif, that leverages the SMACK and Boogie tools and verifies optimized LLVM implementations. We present verifica- tion results obtained over a wide range of constant-time components from the NaCl, OpenSSL, FourQ and other off-the-shelf libraries. The diversity and scale of our ex- amples, as well as the fact that we deal with top-level APIs rather than being limited to low-level leaf functions, distinguishes ct-verif from prior tools. Our approach is based on a simple reduction of constant-time security of a program P to safety of a prod- uct program Q that simulates two executions of P. We formalize and verify the reduction for a core high-level language using the Coq proof assistant.The first two authors were funded by Project “TEC4Growth - Pervasive Intelligence, Enhancers and Proofs of Concept with Industrial Impact/NORTE-01-0145-FEDER-000020”, which is fi- nanced by the North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, and through the European Regional Development Fund (ERDF). The third and fourth authors were supported by projects S2013/ICE2731 N-GREENS Software-CM and ONR Grants N000141210914 (AutoCrypt) and N000141512750 (SynCrypt). The fourth author was also supported by FP7 Marie Cure Actions-COFUND 291803 (Amarout II). We thank Peter Schwabe for providing us with a collection of negative examples. We thank Hovav Shacham, Craig Costello and Patrick Longa for helpful observations on our verification results. TEC4Growth - Pervasive Intelligence, Enhancers and Proofs of Concept with Industrial Impact/NORTE-01-0145-FEDER-000020info:eu-repo/semantics/publishedVersio

Systematic Asynchrony Bug Exploration for Android Apps

Abstract. Smartphone and tablet "apps" are particularly susceptible to asynchrony bugs. In order to maintain responsive user interfaces, events are handled asynchronously. Unexpected schedules of event handlers can result in apparently-random bugs which are notoriously difficult to reproduce, even given the user-event sequences that trigger them. We develop the AsyncDroid tool for the systematic discovery and reproduction of asynchrony bugs in Android apps. Given an app and a user-event sequence, AsyncDroid systematically executes alternate schedules of the same asynchronous event handlers, according to a programmable schedule enumerator. The input user-event sequence is given either by user interaction, or can be generated by automated ui "monkeys". By exposing and controlling the factors which influence the scheduling order of asynchronous handlers, our programmable enumerators can explicate reproducible schedules harboring bugs. By enumerating all schedules within a limited threshold of reordering, we maximize the likelihood of encountering asynchrony bugs, according to prevailing hypotheses in the literature, and discover several bugs in Android apps found in the wild

Knowledge and Attitude toward Zika Virus Disease among Pregnant Women in Iloilo City, Philippines

The recent outbreak of Zika Virus Disease (ZVD) has caused global and local public health concerns especially among pregnant women and women of reproductive age. A descriptive-correlational survey was conducted to determine the knowledge and attitude toward ZVD among pregnant women in Iloilo City. Using a validated self-completion questionnaire, a total of 102 women seeking prenatal consultation in District Health Centers in Iloilo City were conveniently chosen as study participants. Descriptive and non-parametric inferential statistical tools were employed to analyze the data. Results indicated that the most common sources of information about ZVD were the television and radio. Majority of pregnant women had low level of knowledge but had positive attitude toward ZVD. Only a few knew that the disease can spread through sexual contact. While many pregnant women felt that ZVD is a serious disease that can cause serious problems to their babies, only a little more than half believed that they are susceptible of acquiring the disease. A significant relationship was found between knowledge about ZVD and attitude toward the disease. The findings suggest that public health intervention programs must address knowledge gaps and focus on correcting misconceptions to raise awareness and promote favorable attitude toward ZVD

Maternal Responses in the Face of Infection Risk

When animals are sick, their physiology and behavior change in ways that can impact their offspring. Research is emerging showing that infection risk alone can also modify the physiology and behavior of healthy animals. If physiological responses to environments with high infection risk take place during reproduction, it is possible that they lead to maternal effects. Understanding whether and how high infection risk triggers maternal effects is important to elucidate how the impacts of infectious agents extend beyond infected individuals and how, in this way, they are even stronger evolutionary forces than already considered. Here, to evaluate the effects of infection risk on maternal responses, we exposed healthy female Japanese quail to either an immune-challenged (lipopolysaccharide [LPS] treated) mate or to a healthy (control) mate. We first assessed how females responded behaviorally to these treatments. Exposure to an immune-challenged or control male was immediately followed by exposure to a healthy male, to determine whether treatment affected paternity allocation. We predicted that females paired with immune-challenged males would avoid and show aggression towards those males, and that paternity would be skewed towards the healthy male. After mating, we collected eggs over a 5-day period. As an additional control, we collected eggs from immune-challenged females mated to healthy males. We tested eggs for fertilization status, embryo sex ratio, as well as albumen corticosterone, lysozyme activity, and ovotransferrin, and yolk antioxidant capacity. We predicted that immune-challenged females would show the strongest changes in the egg and embryo metrics, and that females exposed to immune-challenged males would show intermediate responses. Contrary to our predictions, we found no avoidance of immune-challenged males and no differences in terms of paternity allocation. Immune-challenged females laid fewer eggs, with an almost bimodal distribution of sex ratio for embryos. In this group, albumen ovotransferrin was the lowest, and yolk antioxidant capacity decreased over time, while it increased in the other treatments. No differences in albumen lysozyme were found. Both females that were immune-challenged and those exposed to immune-challenged males deposited progressively more corticosterone in their eggs over time, a pattern opposed to that shown by females exposed to control males. Our results suggest that egg-laying Japanese quail may be able to respond to infection risk, but that additional or prolonged sickness symptoms may be needed for more extensive maternal responses

Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease : Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts

Background Peripheral artery disease (PAD) and coronary artery disease (CAD) represent atherosclerosis in different vascular beds. We used detailed metabolic biomarker profiling to identify common and discordant biomarkers and clarify pathophysiological differences for these vascular diseases. Methods and Results We used 5 prospective cohorts from Finnish population (FINRISK 1997, 2002, 2007, and 2012, and Health 2000; n=31 657; median follow-up time of 14 years) to estimate associations between >200 metabolic biomarkers and incident PAD and CAD. Metabolic biomarkers were measured with nuclear magnetic resonance, and disease events were obtained from nationwide hospital records. During the follow-up, 498 incident PAD and 2073 incident CAD events occurred. In age- and sex-adjusted Cox models, apolipoproteins and cholesterol measures were robustly associated with incident CAD (eg, hazard ratio [HR] per SD for higher apolipoprotein B/A-1 ratio, 1.30; 95% CI, 1.25-1.36), but not with incident PAD (HR per SD for higher apolipoprotein B/A-1 ratio, 1.04; 95% CI, 0.95-1.14; P-heterogeneity0.05). Lower proportion of polyunsaturated fatty acids relative to total fatty acids, and higher concentrations of monounsaturated fatty acids, glycolysis-related metabolites, and inflammatory protein markers were strongly associated with incident PAD, and many of these associations were stronger for PAD than for CAD (P-heterogeneityPeer reviewe

Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease : Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts

Background Peripheral artery disease (PAD) and coronary artery disease (CAD) represent atherosclerosis in different vascular beds. We used detailed metabolic biomarker profiling to identify common and discordant biomarkers and clarify pathophysiological differences for these vascular diseases. Methods and Results We used 5 prospective cohorts from Finnish population (FINRISK 1997, 2002, 2007, and 2012, and Health 2000; n=31 657; median follow-up time of 14 years) to estimate associations between >200 metabolic biomarkers and incident PAD and CAD. Metabolic biomarkers were measured with nuclear magnetic resonance, and disease events were obtained from nationwide hospital records. During the follow-up, 498 incident PAD and 2073 incident CAD events occurred. In age- and sex-adjusted Cox models, apolipoproteins and cholesterol measures were robustly associated with incident CAD (eg, hazard ratio [HR] per SD for higher apolipoprotein B/A-1 ratio, 1.30; 95% CI, 1.25-1.36), but not with incident PAD (HR per SD for higher apolipoprotein B/A-1 ratio, 1.04; 95% CI, 0.95-1.14; P-heterogeneity0.05). Lower proportion of polyunsaturated fatty acids relative to total fatty acids, and higher concentrations of monounsaturated fatty acids, glycolysis-related metabolites, and inflammatory protein markers were strongly associated with incident PAD, and many of these associations were stronger for PAD than for CAD (P-heterogeneityPeer reviewe