Fermions, Gauge Theories, and the Sinc Function Representation for Feynman Diagrams

We extend our new approach for numeric evaluation of Feynman diagrams to integrals that include fermionic and vector propagators. In this initial discussion we begin by deriving the Sinc function representation for the propagators of spin-1/2 and spin-1 fields and exploring their properties. We show that the attributes of the spin-0 propagator which allowed us to derive the Sinc function representation for scalar field Feynman integrals are shared by fields with non-zero spin. We then investigate the application of the Sinc function representation to simple QED diagrams, including first order corrections to the propagators and the vertex.Comment: 10 pages, Latex, 9 figure

Alternative Numerical Techniques

Two new approaches to numerical QFT are presented.Comment: Lattice2002(theoretical), 3 page

Triterpene saponins from Knautia integrifolia var. bidens

WOS: 000222951900012Two new triterpene saponins (1 and 2), named bidenosides A and B, were isolated from the roots of Knautia integrifolia var. bidens. The structures were identified as 3-O-alpha-L-rhanmopyranosyl-28-O-[beta-D-allopyranosyl-(1 --> 6)-beta-D-glucopyranosyl]-pomolic acid, and 3-O-alpha-L-rhamnopyranosyl-28-O-[beta-D-allopyranosyl-(1 --> 6)-beta-D-glucopyranosyl]-oleanolic acid on the basis of spectroscopic evidence

The First Pentacyclic Triterpenoid Gypsogenin Derivative Exhibiting Anti-ABL1 Kinase and Anti-chronic Myelogenous Leukemia Activities

WOS: 000429294400015PubMed ID: 29386476The discovery of the chimeric tyrosine kinase breakpoint cluster region kinase-Abelson kinase (BCR-ABL)-targeted drug imatinib conceptually changed the treatment of chronic myelogenous leukemia (CML). However, some CML patients show drug resistance to imatinib. To address this issue, some artificial heterocyclic compounds have been identified as BCR-ABL inhibitors. Here we examined whether plant-derived pentacyclic triterpenoid gypsogenin and/or their derivatives show inhibitory activity against BCR-ABL. Among the three derivatives, benzyl 3-hydroxy-23-oxoolean-12-en-28-oate (1c) was found to be the most effective anticancer agent on the CML cell line K562, with an IC50 value of 9.3 mu m. In contrast, the IC50 against normal peripheral blood mononuclear cells was 276.0 mu m, showing better selectivity than imatinib. Compound 1c had in vitro inhibitory activity against Abelson kinase 1 (ABLI) (IC50=8.7 mu m), the kinase component of BCR-ABL. In addition, compound 1c showed a different inhibitory profile against eight kinases compared with imatinib. The interaction between ATP binding site of ABL and lc was examined by molecular docking study, and the binding mode was different from imatinib and newer generation inhibitors. Furthermore, 1c suppressed signaling downstream of BCR-ABL. This study suggests the possibility that plant extracts may be a source for CML treatment and offer a strategy to overcome drug resistance to known BCR-ABL inhibitors.Japan Society for the Promotion of ScienceMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [17H03999]This work was supported in part by a Grant-in-Aid for Scientific Research (B) from the Japan Society for the Promotion of Science (17H03999) (to M. O.)

Solvothermal reactions : an opening-up on the synthesis of novel materials or the development of new processes

During approximately the last 15 years, reactions using a liquid phase either in supercritical or subcritical conditions under high pressure and medium temperatures have been investigated in two different directons..