Digital Fundraising and Racial Justice Challenges and Opportunities for Funders and Fundraisers

This report pools knowledge and insights from the sector to better understand and make visible the barriers different groups face when fundraising online, and offers solutions for funders and fundraisers alike to proactively and meaningfully address them. Specifically, this paper analyses the challenges of digitally fundraising for racial justice work, and highlights existing opportunities to better support organizations and nonprofits in this space with their goals and ambitions

Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma

EGFR and EGFRvIII analysis is of current interest in glioblastoma- the most common malignant primary CNS tumour, because of new EGFRvIII vaccine trials underway. EGFR activation in glioblastoma promotes cellular proliferation via activation of MAPK and PI3K-Akt pathways and EGFRvIII is the most common variant, leading to constitutively active EGFR. This review explains EGFR and EGFRvIII signalling in GBM; describes targeted therapy approaches to date including tyrosine kinase inhibitor, antibody-based therapies, vaccines and preclinical RNA-based therapies and discusses the difficulties encountered with these approaches including pathway redundancy and intratumoural heterogeneity

Developing a Response to Secondary Trauma for American Indian and Rural Service Providers

How can victim service providers, the organizations they work for, and the communities they serve help respond to the issue of occupation-based secondary trauma? Over the last few years, federal agencies in the United States have spent millions in research and programming to answer this important scientific and policy question. The current study builds on this work by describing and evaluating a community-based participatory research project focused on finding manageable, effective, sustainable, and ethical ways to respond to occupation-based secondary trauma in two separate communities: a rural American Indian community, Blackfeet Tribal Nation, and a predominantly white county in Montana, Gallatin County, United States. Findings from evaluation questionnaires (n=178; 80.10% women; 64.60% American Indian; 29.14% White) representing a wide range of occupations document that: (1) the implementation of the project was successful; (2) toolkits created for the project were useful to both individual participants and organizations; (3) training outcomes improved significantly; and (4) findings were consistent across the two different community contexts. Contributions, lessons learned, and future directions are discussed

Driven by Beliefs: Understanding Challenges Physical Science Teachers Face When Integrating Engineering and Physics

It is difficult to ignore the increased use of technological innovations in today’s world, which has led to various calls for the integration of engineering into K-12 science standards. The need to understand how engineering is currently being brought to science classrooms is apparent and necessary in order to address these calls for integration. This multiphase, mixed-methods study investigated the classroom practices and beliefs of high school physical science teachers following an intensive professional development on physics and engineering integration. Classroom observations showed that teachers new to incorporating engineering into their physical science classrooms often struggled to maintain focus on physics concepts, focusing instead on the development of the ‘‘soft skills’’ needed by engineers, such as teamwork or communication. Interviews and surveys further revealed the beliefs of these teachers when considering integrating engineering into physics lessons. Teachers placed student engagement and enjoyment high on their priority list when considering integrating engineering into their classroom. In addition to this somewhat driving force, three main components were identified as important when considering engineering in physical science classrooms: providing hands-on experiences for students, allowing students to apply physics concepts, and developing general problem solving skills that students can take to the ‘‘real-world.’’ While teachers identified both physics and engineering goals for their students, they realized that their students learned more about how to be an engineer. Results from this study provide insight on obstacles current science teachers face as they begin to add engineering to their classrooms. Overall, teachers are motivated to bring engineering to their classrooms as a result of student enjoyment of engineering activities. This may drive the creation of teacher goals for students and determine how emphasis is placed on different goals during these engineering design challenges. Implications for this study include ascertaining knowledge about teacher beliefs prior to professional development, fostering discussions about what integration looks like in the classroom, and modeling the creation of instructional goals that include both physics and engineering content

The relationship between Medicaid policy and realized access to home- and community-based services

Medicaid funding for home- and community-based services (HCBS) has increased substantially in recent decades. Prior research has investigated the effects of this expansion on outcomes for individuals as well as costs to Medicaid, often using state policy as a proxy for access to HCBS or implicitly assuming that more generous policies affect outcomes through access, an assumption that may not hold. In this study, using survey data linked to Medicaid claims, we assess the extent to which common measures of state Medicaid HCBS generosity correspond to increased individual use of HCBS among older adults with potential needs. We find several measures to have strong predictive power, but only with relatively large changes in policy generosity. Our findings imply that increased funding of HCBS is not sufficient to ensure access to services and that researchers should be careful when using state policy generosity as a proxy for access

The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering

Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a process known as inside-out activation. We previously showed that in Drosophila, mutating the integrin binding site in the talin head domain resulted in weakened adhesion to the ECM. Intriguingly, subsequent studies showed that canonical inside-out activation of integrin might not take place in flies. Consistent with this, a mutation in talin that specifically blocks its ability to activate mammalian integrins does not significantly impinge on talin function during fly development. Here, we describe results suggesting that the talin head domain reinforces and stabilizes the integrin adhesion complex by promoting integrin clustering distinct from its ability to support inside-out activation. Specifically, we show that an allele of talin containing a mutation that disrupts intramolecular interactions within the talin head attenuates the assembly and reinforcement of the integrin adhesion complex. Importantly, we provide evidence that this mutation blocks integrin clustering in vivo. We propose that the talin head domain is essential for regulating integrin avidity in Drosophila and that this is crucial for integrin-mediated adhesion during animal development

Effects of a Mobile Fueling Station on Performance in Division III Soccer Players

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 11, 2023. This study aimed to determine if there was an ergogenic effect of utilizing a mobile fueling station in Division III soccer teams. Mobile fueling stations have been shown to be a feasible and sustainable option to support nutrition periodization in college-aged athletes. To date, no studies have analyzed the effect of these stations on athletic performance. We analyzed the effects of this fueling strategy on sprint speed, sprint count, and athlete acceptance during soccer practices and competitions. Athletes from the DeSales University Men’s and Women’s soccer teams (n=35) completed two weeks of data collection in a randomized, crossover design, with one week of fueling using the mobile fueling station (WS), and one week without fueling (NS). In the WS condition, participants ate a carbohydrate-containing snack before soccer practice or competition and ate a snack containing carbohydrates and protein after. Sprint data were collected using GPS sensors, and a post-study questionnaire evaluated athlete acceptance and perceived effectiveness. An a priori alpha level for significance was set at 0.05, and sprint data were analyzed using univariate analysis of variance. While there were no statistically significant differences (p\u3e0.05) in peak (WS=7.65 m/s, NS=7.9 m/s) and mean (WS=6.93 m/s, NS=7.01 m/s) sprint speed or maximum (WS=13, NS=12.16) and mean (WS=8.16, NS=7.46) sprint count, survey responses indicated that 100% of athletes found that mobile fueling stations improved their athletic performance and would like it to be a permanent fixture of their athletic program. These results indicate that mobile fueling stations are perceived as beneficial by Division III soccer players

Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds

Bicyclic or tricyclic nitrogen-containing heterocyclic scaffolds were constructed rapidly by intramolecular nucleophilic aromatic substitution of metallated nitriles tethered by a urea linkage to a series of electronically unactivated heterocyclic precursors. The substitution reaction constitutes a ring expansion, enabled by the conformationally constrained tether between the nitrile and the heterocycle. Attack of the metallated urea leaving group on the nitrile generates a hydantoin that bridges the polycyclic products. X-ray crystallography reveals ring-dependant strain within the hydantoin

The Saliency of Gestural Misinformation in the Perception of a Violent Crime

This is the accepted manuscript version of the following article: Daniel J. gurney, Louise R. Ellis & Emily Vardn-Hynard, ‘The saliencey of gestural misinformation in the perception of a violent crime’, Psychology, Crime & Law, Vol. 22(7): 651-665, first published online 18 April 2016. The version of record is available online via doi: http://dx.doi.org/10.1080/1068316X.2016.1174860 Published by Taylor & Francis Online.Recent research has revealed that misinformation from gestures can influence eyewitness memory. However, while the effects of verbal influence have been shown to have major impacts on prosecution, gestural misinformation is yet to demonstrate misinformation effects to this extent. To investigate the salience of suggestions provided nonverbally, and how these compare to those made verbally, two experiments were conducted. In Experiment 1, participants watched footage of a crime scene and were presented with one of two types of gestures during questioning that suggested different interpretations of the crime. The results confirmed that the gestures influenced responses with participants altering their interpretation of the crime according to the information gestured to them. Experiment 2 built on this to investigate how comparable this gestural influence was to verbal influence. The results revealed that gestural misinformation caused participants to alter their interpretation of the crime and elicited the same effects as verbal misinformation. Additionally, participants were less likely to have felt misled from gestures as they were from speech. These results reveal new insights into the strength of gestural misinformation and show that, despite their subtle nature in communication, gestures can exert a powerful influence in eyewitness interviews.Peer reviewedFinal Accepted Versio

Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq

<p>Abstract</p> <p>Background</p> <p>The male-specific region of the mouse Y chromosome long arm (MSYq) contains three known highly multi-copy X-Y homologous gene families, <it>Ssty1/2</it>, <it>Sly </it>and <it>Asty</it>. Deletions on MSYq lead to teratozoospermia and subfertility or infertility, with a sex ratio skew in the offspring of subfertile MSYqdel males</p> <p>Results</p> <p>We report the highly unusual genomic structure of a novel MSYq locus, <it>Orly</it>, and a diverse set of spermatid-specific transcripts arising from copies of this locus. <it>Orly </it>is composed of partial copies of <it>Ssty1</it>, <it>Asty </it>and <it>Sly </it>arranged in sequence. The <it>Ssty1- </it>and <it>Sly-</it>derived segments are in antisense orientation relative to each other, leading to bi-directional transcription of <it>Orly</it>. Genome search and phylogenetic tree analysis is used to determine the order of events in mouse Yq evolution. We find that <it>Orly </it>is the most recent gene to arise on Yq, and that subsequently there was massive expansion in copy number of all Yq-linked genes.</p> <p>Conclusion</p> <p><it>Orly </it>has an unprecedented chimeric structure, and generates both "forward" (<it>Orly</it>) and "reverse" (<it>Orlyos</it>) transcripts arising from the promoters at each end of the locus. The region of overlap of known <it>Orly </it>and <it>Orlyos </it>transcripts is homologous to <it>Sly </it>intron 2. We propose that <it>Orly </it>may be involved in an intragenomic conflict between mouse X and Y chromosomes, and that this process underlies the massive expansion in copy number of the genes on MSYq and their X homologues.</p