On January 2, 2005, the scientific community lost a valued colleague and friend. Maclyn McCarty, or “Mac,” as he was better known, was perhaps most recognized for his part in the discovery of DNA as the carrier of genetic information. But McCarty's scientific career was long and fruitful, and his contributions to science were vast. This retrospective offers a look at some of Mac's other notable scientific achievements

Fischetti, Vincent A.

Gotschlich, Emil C.

Crossref

PubMed Central

English

Amino acid sequence and physicochemical similarities between streptococcal M protein and mammalian tropomyosin.

Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever.

Association of experimental chronic arthritis with the persistence of group A streptococcal cell walls in the articular tissue.

Determination of C-reactive protein in the blood as a measure of the activity of the disease process in acute rheumatic fever.

Electron microscopic studies on opaque colony varients of group A streptococci.

Electrophoretic studies of the extracellular products of group A streptococci.

Further studies on the chemical basis for serological specificity of group A streptococcal carbohydrate.

Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance.

High-resolution 1H- and 13C-n.m.r. spectra of the group A-variant streptococcal polysaccharide.

Historical perspective on C-reactive protein.

Missing links in the streptococcal chain leading to rheumatic fever.

Nature of rheumatic fever.

Present state of knowledge concerning pathogenesis and treatment of rheumatic fever.

Proton nuclear magnetic resonance measurement of the amide hydrogen exchange rated of group A streptococci polysaccharide in

Quantitative antistreptokinase studies in patients infected with group A hemolytic streptococci: a comparison with serum antistreptolysin and gamma globulin levels with special reference to the occurrence of rheumatic fever.

Relation of rheumatic-like cardiac lesions of the mouse to localization of group A streptococcal cell walls.

Streptococci and streptococcal diseases.

Studies of diphtheria antitoxin in rheumatic fever subjects: analysis of reactions to the Schick test and of antitoxin responses following hyperimmunization with diphtheria toxoid.

Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III.

Studies on the chemical structure of the streptococcal cell wall. II. The composition of group C cell walls and chemical basis for serologic specificity of the carbohydrate moiety.

Teichoic acids in walls and cells of grampositive bacteria.

The analysis of streptococcal infections. V. Cardiotoxicity of streptolysin O for rabbits in vivo.

The inhibition of streptococcal desoxyribonuclease by rabbit and human antisera.

The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus.

The measurement of C-reactive protein in human sera; comparison of the clinical tests on the basis of a quantitative method.

The nature of the opaque colony variation in group A streptocci.

The occurrence during acute infections of a protein not normally present in the blood.

The occurrence during acute infections of a protein not normally present in the blood. V. Physical-chemical properties of the C-reactive protein crystallized by a modified technique.

The occurrence in the rabbit of an acute phase protein analogous to human C reactive protein.

The occurrence of nucleases in culture filtrates of group A streptococci.

The occurrence of polyglycerophosphate as an antigenic component of various gram-positive bacterial species.

The role of D-alanine on the serological specificity of group A streptococcal glycerol teichoic acid.