19 research outputs found
The platelet ATP and ADP receptors.
Full text linkpeer reviewedThis review focuses on recent findings on the physiology of these platelet ADP and ATP receptors, their distinct downstream intracellular signaling pathways as well as on the available agonists, antagonists and inhibitors that allow their pharmacological discrimination
Does the P(2X1del) variant lacking 17 amino acids in its extracellular domain represent a relevant functional ion channel in platelets?
Full text linkIn this letter, we questionned the existence of a ADP responsive P2X1 protein variant in platelets
The P2Y1 receptor antagonist adenosine-2',5'-diphosphate non-selectively antagonizes the platelet P2X1 ion channel.
Full text linkThis letter indicates a lack of specificity of a platelet P2Y1 receptor antagonist
Ca2+ influx via the platelet P2X1 ion channel contributes to collagen-induced platelet activation.
Full text linkADP-induced activation of the extracellular-regulated kinase/mitogen-activated protein kinase pathway via the ionotropic P2X1 receptor in platelets.
Full text linkRapid Ca2+ influx via the platelet P2X1 ion channel requires its N- and C-terminal tyrosine phosphorylation.
Full text linkP2X1-induced activation of Ca2+ calmodulin leads to myosin light chain and ERK2 phosphorylation in human platelets.
Full text linkP2X1-mediated activation of Ca2+-calmodulin leads to myosin light chain and ERK2 phosphorylation in human platelets.
Full text linkThe ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen.
Full text linkThis study shows that, during collagen-initiated platelet activation, the early secretion of ATP results in the activation of the P2X1 ion channel, which plays a role as a positive regulator of further platelet responses
The P2X1 ion channel in platelets acts as a functional receptor for ATP and is weakly antagonized by ADP.
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