20 research outputs found
20 years since Pauline Pantsdown
Full text linkTelevision interview profiling my career as satirist/activist Pauline Pantsdow
Biosynthesis of glucosyl monophosphoryl undecaprenol and its role in lipoteichoic acid biosynthesis
No full textIncorporation of 3,4-dihydroxybutyl-1-phosphonate, a glycerol 3-phosphate analogue, into the cell wall of Bacillus subtilis
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Effects of penicillin on synthesis and excretion of lipid and lipoteichoic acid from Streptococcus mutans BHT
No full textBiosynthesis of D-alanyl-lipoteichoic acid in Lactobacillus casei: D-alanyl-lipophilic compounds as intermediates
No full textSynthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus
No full textLipoteichoic acid (LTA), a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. However, the molecular basis for its synthesis or function is not known. Here we report that Staphylococcus aureus LtaS synthesizes glycerol phosphate LTA. Construction of a mutant S. aureus strain with inducible ltaS expression revealed that LTA synthesis is required for bacterial growth and cell division. An ltaS homologue of Bacillus subtilis restored LTA synthesis and the growth of ltaS mutant staphylococci. Thus, LtaS inhibition can be used as a target to treat human infections caused by antibiotic-resistant S. aureus or other bacterial pathogens
