Chapter Il racconto dei luoghi: indagini storico-rappresentative della facciata della chiesa di san Matteo a Scicli

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences

A Digital representation of Euryalus fortress: a historical interpretive study

[EN] It is clear that concepts and cognitive processes aimed at putting forward fortified systems in their relation with the territory and with the surrounding landscape, establish inextricably interwoven “interests” and a consequent osmotic hysteresis between their emergence and disappearance into the deepest part of the earth. The logic behind the defensive structures of Euryalus fortress is particularly interesting. The fortress designed during the Greek period and located on the top of Epipolae hill, represented a strategic fortification for the city’s defence. Therefore, it is reasonable to think about a sequence of emerging or disappearing empty spaces; a semantic vacuum to be filled with logical-subjective interpretations pertaining to those who visit the place. The conceptual framework provides knowledge and documentation meant as indispensable supporting instruments to understand Dionysius I and Archimedes’ thoughts where the integration of people and environment forms the basis of the close iterative connection among nature, artifice and landscape. The research takes this direction implementing innovative technological systems trying to go beyond in order to achieve virtual reconstruction processes, even if partial, of the fortress. Survey, thus, can be applied as an instrument for the knowledge of historical heritage which once converted into digital heritage is a support for the reconstruction of lost ancient scenarios. Actually, the implementation of innovative systems allows an easy-to-use data viewing which supports the interpretive phase, the archiving, consultation and dissemination of survey products. In particular, the survey of the fortress with integrated methodologies (both instrumental and photogrammetric) provides not only a fundamental basis for the documentation of the fortress conditions but also provides a basis for the collection of reconstructive hypotheses formulated by researchers who have been involved with the structure so far. Interactions among archaeology, history, geomorphology and technology make history and a past renowned glory come alive with the common spirit of coming up to a strong synergy between the past and the future destiny of the place.Valenti, R.; Giuliano, S.; Paternò, E. (2020). Una rappresentazione digitale del castello Eurialo per l’indagine storico-interpretativa. Editorial Universitat Politècnica de València. 487-494. https://doi.org/10.4995/FORTMED2020.2020.11526OCS48749

The prognostic role of tumor size in early breast cancer in the era of molecular biology.

The prognosis of early breast cancer (EBC) depends on patient and tumor characteristics. The association between tumor size, the largest diameter in TNM staging, and prognosis is well recognized. According to TNM, tumors classified as T2, could have very different volumes; e.g. a tumor of 2.1 cm has a volume of 4500 mm3, while a tumor of 4.9 cm has a volume of 60.000 mm3 even belonging to the same class. The aim of the study is to establish if the prognostic role of tumor size, expressed as diameter and volume, has been overshadowed by other factors.The primary objective is to evaluate the association between tumor dimensions and overall survival (OS) / disease free survival (DFS), in our institution from January 1st 2005 to September 30th 2013 in a surgical T1-T2 population. Volume was evaluated with the measurement of three half-diameters of the tumor (a, b and c), and calculated using the following formula: 4/3π x a x b x c.341 patients with T1-T2 EBC were included. 86.5% were treated with conservative surgery. 85.1% had a Luminal subtype, 9.1% were Triple negative and 7.4% were HER2 positive. Median volume was 942 mm3 (range 0.52-31.651.2). 44 patients (12.9%) relapsed and 23 patients died. With a median follow-up of 6.5 years, the univariate analysis for DFS showed an association between age, tumor size, volume, histological grading and molecular subtype. The multivariate analysis confirmed the statistically significant association only for molecular subtype (p 0.005), with a worse prognosis for Triple negative and HER2 positive subtypes compared with Luminal (HR: 2.65; 95%CI: 1.34-5.22). Likewise for OS, an association was shown by the multivariate analysis solely for molecular subtype (HER2 and Triple negative vs. Luminal. HR: 2.83; 95% CI:1.46-5.49; p 0.002).In our study, the only parameter that strongly influences survival is molecular subtype. These findings encourage clinicians to choose adjuvant treatment not based on dimensional criteria but on biological features

Association with OS (Cox proportional hazard model).

<p>Association with OS (Cox proportional hazard model).</p

DFS for different molecular subtype.

<p>DFS for different molecular subtype.</p

Association with DFS (Cox proportional hazard model).

<p>Association with DFS (Cox proportional hazard model).</p