Diabetes Mellitus Risk Assessment Among Egyptians Versus Saudi Arabians Nursing Employees: Comparative Study

Purpose: Diabetes mellitus is the uppermost vital public health challenges in the world. More than 150 million adults are affected and the total number is predicted to double in the next 25 years. The present study aiming to assess the diabetes mellitus risk among Egyptians versus Saudi Arabian's nursing employees. Methods: A convenient sample of 150 employees from each country were collected. The study was conducted at faculties of Nursing at Menoufia University, Egypt and Jouf University, Kingdom of Saudia Arabia. Two tools were utilized for data collection, self-administered questionnaire and self-risk assessment screening score. Results: Both groups had a good total knowledge score (74% of Egyptians vs. 58% of Saudi Arabians) with a statistically significant difference. More than half of Egyptians had negative attitude compared to nearly half of Saudi Arabians who had a positive attitude. Nearly two-thirds of Egyptians had good practice vs. 44% of Saudi Arabians who had a bad practice. More than two-thirds of Egyptians vs. more than three-fourths of Saudi Arabians were scored high risk for diabetes mellitus. Conclusion: Based on the findings, there were statistically significant differences among Egyptians versus Saudi Arabian's nursing employees in total knowledge, practice and attitude scores of diabetes mellitus. Total risk assessment screening score of diabetes mellitus has shown a statistically significant difference between both groups. Recommendations: Large-scale awareness programs should be implemented after identifying the appropriate means to spread the message to the common population about all aspects of diabetes. Keywords: Diabetes mellitus, Knowledge, Practices, Attitude, Risk assessment. DOI: 10.7176/JHMN/59-0

<i>Actinidia deliciosa</i> Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

Type 2 diabetes (T2D) is a chronic metabolic condition associated with obesity, oxidative stress-mediated inflammation, apoptosis, and impaired insulin signaling. The utilization of phytochemical therapy generated from plants has emerged as a promising approach for the treatment of diabetes and its complications. Kiwifruit is recognized for its substantial content of antioxidative phenolics. Therefore, this work aimed to examine the effect of Actinidia deliciosa (kiwi fruit) on hepatorenal damage in a high-fat diet (HFD) and streptozotocin (STZ)-induced T2D in rats using in vivo and in silico analyses. An increase in hepatic and renal lipid peroxidation was observed in diabetic rats accompanied by a decrease in antioxidant status. Furthermore, it is important to highlight that there were observable inflammatory and apoptotic responses in the hepatic and renal organs of rats with diabetes, along with a dysregulation of the phosphorylation levels of mammalian target of rapamycin (mTOR), protein kinase B (Akt), and phosphoinositide 3-kinase (PI3K) signaling proteins. However, the administration of kiwi extract to diabetic rats alleviated hepatorenal dysfunction, inflammatory processes, oxidative injury, and apoptotic events with activation of the insulin signaling pathway. Furthermore, molecular docking and dynamic simulation studies revealed quercetin, chlorogenic acid, and melezitose as components of kiwi extract that docked well with potential as effective natural products for activating the silent information regulator 1(SIRT-1) pathway. Furthermore, phenolic acids in kiwi extract, especially syringic acid, P-coumaric acid, caffeic acid, and ferulic acid, have the ability to inhibit the phosphatase and tensin homolog (PTEN) active site. In conclusion, it can be argued that kiwi extract may present a potentially beneficial adjunctive therapy approach for the treatment of diabetic hepatorenal complications