Fungus paranasal sinusitis in non- immunocompromised patients in Tehran, Iran (2006-07)

Background and Objective: Incidence of fungal infections particularly fungal sinusitis is increasing in Iran and identification of causative agents is essential for its control and treatment. This study was carried out to determine the fungus paranasal sinusitis in non- immunocompromised patients in Tehran, Iran. Materials and Methods: This cross – sectional study was done on 108 patients (73 males, 35 females) with chronic sinusitis ranged from 9 to 68 years, admitted to Amir Alam and Emam Khomeini hospitals in Tehran, Iran during 2006-07. Sinusitis in patients confirmed by radiologic images. Complementry information were obtained using questionnaires which including gender, job, presence of disposing disease diabetes and consumption immunocompromised drugs. Sinus samples were collected by washing and biopsy were carried out by two methods of fenestration and Cald-wel luc operations. Subsequently they were cultured on Sabouraud dextrose agar (SDA), SDA+chloramphenicol and blood agar (BA) media at 30°C and 37°C. Direct examination and fixative sample for histhologic evaluation was done and for colonies confirmation the slide culture method also was used. Results: 8 cases (7.4 %) were positive for fungal sinusitis with following sub type: 6 cases (Alternaria Spp), 1 case (Paecilomyces) and 1 case (Aspergillus flavus). The most fungal sinusitis (5 cases) were observed in 30-39 years patients. Conclusion: Considering the prevalence of 7.4 % fungal sinusitis and isolation of paecilomyces which is a rare subtype complematry investigation is recommended, in the field of research

Effect of intravenous Vitamin C on sleep quality in hemodialysis patients

Background and Objective: Poor sleep quality is common among hemodialysis patients and can potentially predict morbidity, mortality and quality of life in these patients. On the other hand, hemodialysis patients are encountered with vitamin C deficiency. The purpose of this study was to determine the effect of intravenous vitamin C on sleep quality in hemodialysis patients. Materials and Methods: In this double blind randomized clinical trial, 60 qualified hemodialysis patients were gone under investigation in Sari a city located in North of Iran during 2010. Patients randomly allocated in two equal intervention and control groups. The main measured outcome was the Pittsburg sleep quality index (PSQI) which consists of seven components. At the end of each hemodialysis session, Intervention group received vitamin C vial (500mg/5cc) intravenously, three times a week for 8 weeks and control group received normal saline in a same way. Data were collected at pretreatment and after two months of treatment. Data were analyzed by Independent t test, Paired t test, Wilcoxon and Chi-Square tests. Results: The result indicated that the sleep quality improves significantly in vitamin C group but not in control group (P<0.001). Vitamin C caused significant improvement in subjective sleep quality, sleep latency, habitual sleep efficiency and sleep disturbances in intervention group (p<0.05). Also, Global PSQI score of intervention group had a greater improvement than control group. Moreover vitamin C caused significant improvement in subjective sleep quality, sleep latency, habitual sleep efficiency and sleep disturbances in intervention group after treatment (p<0.05). Conclusion: This study showed that intravenous vitamin C can effectively improve sleep quality in hemodialysis patients