5 research outputs found
Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine
Proton pump inhibitors (PPIs) have been shown
to be effective in preventing gastric and duodenal ulcers in
high-risk patients taking nonsteroidal anti-inflammatory
drugs (NSAIDs); by contrast, scarce information is available
concerning the effects of PPIs on intestinal damage
induced by NSAIDs in humans or in experimental animals.
We examined the effects of lansoprazole and omeprazole on
the intestinal injury induced by indomethacin in the
conscious rat. PPIs were administered by the intragastric
route at 30, 60 and 90 μmol/kg, 12 h and 30 min before and
6 h after indomethacin treatment. The effects of omeprazole
and lansoprazole were evaluated on: (1) macroscopic and
histologic damage; (2) mucosal polymorphonuclear cell
infiltration; (3) oxidative tissue damage and (4) bacterial
translocation from lumen into the intestinal mucosa.
Lansoprazole and omeprazole (at 90 μmol/kg) significantly
decreased (P<0.01) the macroscopic and histologic damage
induced by indomethacin in the rat small intestine.
Furthermore, both drugs greatly reduced (P<0.01) the
associated increases in myeloperoxidase levels and lipid
peroxidation induced by indomethacin, whereas they only
moderately affected (P<0.05) the translocation of enterobacteria
from lumen into the intestinal mucosa. These data
demonstrate that omeprazole and lansoprazole can protect
the small intestine from the damage induced by indomethacin
in the conscious rat. The intestinal protection, possibly
related to antioxidant and anti-inflammatory properties of
these drugs, may suggest new therapeutic uses of PPIs in
intestinal inflammatory diseases