NDM-539: IRON ORE MINE WASTE FLOODWATER EXTENT MAPPING UTILIZING REMOTE SENSING DERIVED INDICES

The collapse of two iron ore mine dams in south-eastern Brazil on 5 November 2015 is one of the recent environmental disasters. The clean-up and environment recovery would take several years and cost billions of dollars. Mapping the extent of the affected areas and monitoring the water quality deterioration is a challenge. In this study the new optical satellite SENTINEL 2 imagery along LANDSAT 8 were utilized to test the applicability of the Land Surface Water Index (LSWI) and Modified Normalized Difference Water Index (MNDWI) in the mapping process. The systematic coverage of the study area from the aforementioned satellites before and after the incident were studied and compared. The dynamics of LSWI, MNDWI were utilized in the delineation of the affected areas. Both quantitative and qualitative measures to assess the mine waste floodwater extent were developed. The high reflectance in both the 650-nm and 750-nm wavebands as an indication of Iron-Oxide precipitates occurrence was also tested. The study revealed that the mine tailings extended about 500 Km downstream. The affected areas and extent revealed from the study results were validated against the official figures from the Brazilian government. There was a good agreement between the study results and the published figures. The temporal variation in the Iron-Oxide precipitates occurrence was successfully mapped. In addition, visual interpretation go well with the study results. The findings of this study indicates that the proposed algorithm can be used in the timely mapping of the iron ore mine waste floodwater disaster

Who will dominate the global fossil fuel trade?

Fossil fuels are not distributed evenly throughout the world, and hence the countries rely heavily on international trade to secure energy supply. Characterization of the energy trade network is needed to conduct long-term assessments of energy security. This study proposes a modeling framework to assess the evolution of energy trade under current conditions as well as under future scenarios up to 2050. The total trade of each country is estimated with trade predictive models (TPMs) using key variables. Subsequently, a matrix-balancing method (RAS) is used to estimate the annual bilateral trades. The projected energy trade network in 2050 varies under each shared socioeconomic pathway (SSP) of the future, with annual fossil fuel global trades among countries ranging between 538 and 215 EJ. Canada, USA, Venezuela, and China are projected to dominate the global trade network, with Canada-USA remaining the most dominant fossil fuel trade link up to 2050

Cooperation in a transboundary river basin: a large-scale socio-hydrological model of the Eastern Nile

While conflict-and-cooperation phenomena in transboundary basins have been widely studied, much less work has been devoted to representing the process interactions in a quantitative way. This paper identifies the main factors in the riparian countries' willingness to cooperate in the Eastern Nile River basin, involving Ethiopia, Sudan, and Egypt, from 1983 to 2016. We propose a quantitative model of the willingness to cooperate at the national and river basin scales. Our results suggest that relative political stability and foreign direct investment can explain Ethiopia's decreasing willingness to cooperate between 2009 and 2016. Further, we show that the 2008 food crisis may account for Sudan recovering its willingness to cooperate with Ethiopia. Long-term lack of trust among the riparian countries may have reduced basin-wide cooperation. While the proposed model has some limitations regarding model assumptions and parameters, it does provide a quantitative representation of the evolution of cooperation pathways among the riparian countries, which can be used to explore the effects of changes in future dam operation and other management decisions on the emergence of conflict and cooperation in the basin

The First International Mini-Symposium on Methionine Restriction and Lifespan

It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et al., 1993). Since then, several studies have replicated the effects of dietary methionine restricted (MR) in delaying age-related diseases (Richie et al., 1994; Miller et al., 2005; Ables et al., 2012; Sanchez-Roman and Barja, 2013). We report the abstracts from the First International Mini-Symposium on Methionine Restriction and Lifespan held in Tarrytown, NY, September 2013. The goals were (1) to gather researchers with an interest in MR and lifespan, (2) to exchange knowledge, (3) to generate ideas for future investigations, and (4) to strengthen relationships within this community. The presentations highlighted the importance of research on cysteine, growth hormone (GH), and ATF4 in the paradigm of aging. In addition, the effects of dietary restriction or MR in the kidneys, liver, bones, and the adipose tissue were discussed. The symposium also emphasized the value of other species, e.g., the naked mole rat, Brandt's bat, and Drosophila, in aging research. Overall, the symposium consolidated scientists with similar research interests and provided opportunities to conduct future collaborative studies (Figure 3)

Evaluation of Some Prognostic Biomarkers in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma

Background: Human papillomavirus (HPV)-related multi phenotypic sinonasal carcinoma (HMSC) is a recently described tumor subtype with an unknown prognosis, often misdiagnosed with other sinonasal carcinomas, and associated with high-risk HPV (HR-HPV). The present study aimed to evaluate the expression of vascular endothelial growth factor (VEGF), Bcl-2-associated X protein (BAX), epidermal growth factor receptors (EGFR), ProEx™C, and human telomerase reverse transcriptase (hTERT) and assess their association with survival and clinicopathological characteristics.Methods: Between 2017 and 2022, 40 HMSC patients underwent surgical resection at the School of Medicine, Zagazig University Hospitals (Zagazig, Egypt). Tissue samples were examined for the presence of HR-HPV; absence of myeloblastosis (MYB), MYB proto-oncogene like 1 (MYBL1), and nuclear factor I/B (NFIB) fusions and the presence of myoepithelial proteins (calponin, S100, SMA), squamous differentiation markers (p63, p40, calponin), VEGF, BAX, ProEx™C, and hTERT by immunohistochemistry. All patients were followed up for about 54 months until death or the last known survival data. Data were analyzed using the Chi square test and Kaplan-Meier method.Results: The expression of VEGF, hTERT, and ProEx™C was significantly associated with age, advanced tumor stages, lymph node metastasis, tumor size, mortality, relapse, poor disease-free survival (DFS), and overall survival (OS) (P<0.001). BAX expression was significantly associated with tumor size, age, poor DFS, and relapse (P=0.01, P<0.001, P=0.035, and P=0.002, respectively). Conclusion: HMSC is strongly associated with HR-HPV. The expression of VEGF, EGFR, BAX, hTERT, and ProEx™C is associated with aggressive malignant behavior, poor survival, and poor prognosis, making them novel prognostic biomarkers for targeted therapeutics in HMSC

Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae

10.1371/journal.pone.0064448PLoS ONE85

Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women

Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary metabolism. Understanding the biochemical networks that underlie metabolic homeostasis and how they associate with insulin action will help unravel diabetes etiology and should foster discovery of new biomarkers of disease risk and severity. We examined differences in plasma concentrations of >350 metabolites in fasted obese T2DM vs. obese non-diabetic African-American women, and utilized principal components analysis to identify 158 metabolite components that strongly correlated with fasting HbA1c over a broad range of the latter (r = −0.631; p<0.0001). In addition to many unidentified small molecules, specific metabolites that were increased significantly in T2DM subjects included certain amino acids and their derivatives (i.e., leucine, 2-ketoisocaproate, valine, cystine, histidine), 2-hydroxybutanoate, long-chain fatty acids, and carbohydrate derivatives. Leucine and valine concentrations rose with increasing HbA1c, and significantly correlated with plasma acetylcarnitine concentrations. It is hypothesized that this reflects a close link between abnormalities in glucose homeostasis, amino acid catabolism, and efficiency of fuel combustion in the tricarboxylic acid (TCA) cycle. It is speculated that a mechanism for potential TCA cycle inefficiency concurrent with insulin resistance is “anaplerotic stress” emanating from reduced amino acid-derived carbon flux to TCA cycle intermediates, which if coupled to perturbation in cataplerosis would lead to net reduction in TCA cycle capacity relative to fuel delivery