Stability-Indicating Micelle-Enhanced Spectrofluorimetric Method For Determination of Tamsulosin Hydrochloride In Dosage Forms.

A rapid, simple and highly sensitive spectrofluorimetric method is developed for the determination of Tamsulosin hydrochloride (Tams.HCl) in pharmaceutical formulations. The proposed method is based on investigation of the fluorescence spectral behavior of Tams.HCl in a sodium dodecyl sulphate (SDS) micellar system. In aqueous solution of Tris buffer of pH 7±0.2, SDS causes marked enhancement in the fluorescence intensity of Tams.HCl (about +110%). The fluorescence intensity is measured at 328 nm after excitation at 280 nm and the fluorescence-concentration plots are rectilinear over the range 0.1-1.2 µg ml-1, with lower detection limit of 0.027 µg ml-1 and quantification limit of 0.09 µg ml-1. The method is successfully applied to the analysis of the studied drug in its commercial capsules, and the results are in good agreement with those obtained with the official method. The application of the proposed method is extended to stability studies of Tamsulosin hydrochloride after exposure to different forced degradation conditions, such as acidic, alkaline and oxidative conditions, according to ICH guidelines

On The Solvability Of Some Diophantine Equations Of The Form ax+by = z2

The Diophantine equation ax+py = z2 where p is prime is widely studied by many mathematicians. Solving equations of this type often include Catalan’s conjecture in the process of proving these equations. Here, we study the non-negative integer solutions for some Diophantine equations of such family. We will use Mihailescu’s theorem (which is the proof of Catalan’s conjecture) and elementary methods to solve the Diophantine equations 16x −7y = z2, 16x − py = z2 and 64x − py = z2, then we will study a generalization where (4n)x − py = z2 and x, y, z,n are non-negative integers. By using Mihailescu’s theorem and a fundamental approach in the theory of numbers, namely the theory of congruence, we will determine the solution of the Diophantine equations 7x+11y = z2, 13x+17y = z2, 15x+17y = z2 and 2x+257y = z2 where x, y and z are non-negative integers. Also, we will prove that for any non-negative integer n, all non-negative integer solutions of the Diophantine equation 11n8x+11y = z2 are of the form (x, y, z) = (1,n,3(11) n2 ) where n is even, and has no solution when n is odd. Finally, we will concentrate on finding the solutions of the Diophantine equation 3x+ pmny = z2 where y = 1,2 and p > 3 a prime number

Das Problem der transzendenten sinnlichen Wahrnehmung in der spätmuʿtazilitischen Erkenntnistheorie nach der Darstellung des Taqīaddīn an-Nağrānī

Zugl.: Saarbrücken, Univ., Diss.Elsayed ElshahedText teilw. arab. u. dt

MHD flow of an elastico-viscous fluid under periodic body acceleration

Magnetohydrodynamic (MHD) flow of blood has been studied under the influence of body acceleration. With the help of Laplace and finite Hankel transforms, an exact solution is obtained for the unsteady flow of blood as an electrical conducting, incompressible and elastico-viscous fluid in the presence of a magnetic field acting along the radius of the pipe. Analytical expressions for axial velocity, fluid acceleration and flow rate has been obtained