92 research outputs found
An expeditious and green synthesis of new enaminones and study their chemical reactivity toward some different amines and binucleophiles under environmentally friendly conditions
AbstractThe condensation reaction of 3-heteroaromatic-3-oxopropanenitriles 3, 4 and 7 with dimethylformamide–dimethylacetal (DMF–DMA) gave the corresponding enaminones 8, 9 and 10, respectively. Nucleophilic substitution of 8 and 9 with different amines resulted in a new derivatives of enaminones 11–18. The reactivity of enaminones 8 and 9 toward some nitrogen nucleophiles was investigated with a view to synthesize new heterocyclic systems. Thus, treatment of compounds 8 and 9 with phenylhydrazine afforded the pyrazole derivatives 19 and 20, respectively. On the other hand, reacting 8 and 9 with guanidine gave the pyrimidines 21 and 22, respectively. Treatment of compound 9 with hydroxylamine hydrochloride afforded the aminoisoxazoles 23. The foregoing reactions were carried out with conventional heating and under green conditions [ultrasound (US) irradiations or ionic liquids (ILs)] and a comparative study was employed. All the new structures are fully characterized
STUDIES WITH POLYFUNCTIONALLY SUBSTITUTED HETEROAROMATICS: A NEW ROUTE TO POLYFUNCTIONALLY SUBSTITUTED ANNELATED MERCAPTOPHTHALAZINES
Reaktionen mit heterocyclischen Amidinen, VII: Synthese einiger neuer Pyrazolo[1,5-c]-1,2,4-triazine, Pyrazolo[1,5-a]-1,3,5-triazine und Pyrazolo[1,5-a]pyrimidine
Untersuchungen an 5-Aminopyrazolderivaten. Synthese von verschiedenen neuen kondensierten Pyrazolderivaten
Untersuchungen an 5-Aminoisoxazol-Derivaten: Synthese einiger neuer kondensierter Isoxazole
Nitrile bei organischen Synthesen: Die Reaktion von Trichloracetonitril mit aktiven Methylen-Reagentien
Heterocyclic synthesis with nitriles: New routes for synthesis of pyridazines, pyridines and their fused derivatives
?,?-Unges�ttigte Nitrile in der Heterocyclen-Synthese: Synthese einiger neuer Pyrazolo[1,5-a]pyrimidin-Derivate
STUDIES WITH ALKYLHETEROCYCLIC CARBONITRILES: A NOVEL SYNTHETIC ROUTE TO SEVERAL NEW ANNELATED PYRAZOLO[5,1- C
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