Understanding The Effects Of Stellar Multiplicity On The Derived Planet Radii From Transit Surveys: Implications for Kepler, K2, and TESS

We present a study on the effect of undetected stellar companions on the derived planetary radii for the Kepler Objects of Interest (KOIs). The current production of the KOI list assumes that the each KOI is a single star. Not accounting for stellar multiplicity statistically biases the planets towards smaller radii. The bias towards smaller radii depends on the properties of the companion stars and whether the planets orbit the primary or the companion stars. Defining a planetary radius correction factor $X_R$, we find that if the KOIs are assumed to be single, then, {\it on average}, the planetary radii may be underestimated by a factor of $\langle X_R \rangle \approx 1.5$. If typical radial velocity and high resolution imaging observations are performed and no companions are detected, this factor reduces to $\langle X_R \rangle \approx 1.2$. The correction factor $\langle X_R \rangle$ is dependent upon the primary star properties and ranges from $\langle X_R \rangle \approx 1.6$ for A and F stars to $\langle X_R \rangle \approx 1.2$ for K and M stars. For missions like K2 and TESS where the stars may be closer than the stars in the Kepler target sample, observational vetting (primary imaging) reduces the radius correction factor to $\langle X_R \rangle \approx 1.1$. Finally, we show that if the stellar multiplicity rates are not accounted for correctly, occurrence rate calculations for Earth-sized planets may overestimate the frequency of small planets by as much as $15-20$\%.Comment: 10 pages, 6 Figures, Accepted for publication in The Astrophysical Journal (Fix typo in Equation 6 of original astroph submission; correction also submitted to Journal

Land-use Compatibility is a Matter of Design, Not Distance

Mixed-use development is essential for a sustainable, high-quality urban lifestyle. Mixed-use development implies fewer automotive trips, shorter travel times, smaller dwelling units, enhanced walkability, and a stronger sense of community. Despite these clear advantages, single-use zoning remains prevalent in cities today as advocates point to issues like compatibility of land-use and the isolation of noise, pollution, and hazards. Single-use zoning was essential for public health and welfare at the turn of the 20th century, mixed-use development is essential for health and welfare in the 21st century. As our society has evolved, land-use compatibility has become a matter of design, not distance

Intercollegiate Cross Country Competition: Effects of Warm-up and Racing on Salivary Levels of Cortisol and Testosterone

International Journal of Exercise Science 7(4) : 318-328, 2014. Team intercollegiate athletic competition is associated with an increase in salivary cortisol (C) and testosterone (T) in men and women. The present study was designed to determine the hormonal effects of warm-up and racing in cross country runners – a sport that has both individual and team components. Members of the Emory University men’s and women’s varsity cross country teams gave saliva samples before warm-up, after warm-up, and immediately after the finish of each of two intercollegiate invitational meets held one year apart in the same setting (2010, N = 10 men, 15 women; 2011, N = 15 men, 20 women ). For some racers warm-up was associated with a significant decrease in C (2010 men p = .04; 2011 women, p = .004). With the exception of the 2011 men, warm-up was associated with an increase in T (2010 men, P = .012; 2010 women, p = .006; 2011 women, p = .056). For men and women in both years, racing was related to a substantial increase in both C and T (C: 2010 and 2011 men, p = .001; 2010 women, p = .011; 2011 women, p \u3c .001) (T: 2010 and 2011 men and women, p \u3c .001). Finish time was not related to levels of C or T. Increased hormone levels may result from the psychological effects of competition, physical exertion, or some combination of the two. Competition-related increases in C and T presumably benefit performance in cross country racing and other sports, but the exact character of these benefits remains to be determined

Apolipoprotein-E forms dimers in human frontal cortex and hippocampus

<p>Abstract</p> <p>Background</p> <p>Apolipoprotein-E (apoE) plays important roles in neurobiology and the apoE4 isoform increases risk for Alzheimer's disease (AD). ApoE3 and apoE2 are known to form disulphide-linked dimers in plasma and cerebrospinal fluid whereas apoE4 cannot form these dimers as it lacks a cysteine residue. Previous in vitro research indicates dimerisation of apoE3 has a significant impact on its functions related to cholesterol homeostasis and amyloid-beta peptide degradation. The possible occurrence of apoE dimers in cortical tissues has not been examined and was therefore assessed. Human frontal cortex and hippocampus from control and AD post-mortem samples were homogenised and analysed for apoE by western blotting under both reducing and non-reducing conditions.</p> <p>Results</p> <p>In apoE3 homozygous samples, ~12% of apoE was present as a homodimer and ~2% was detected as a 43 kDa heterodimer. The level of dimerisation was not significantly different when control and AD samples were compared. As expected, these dimerised forms of apoE were not detected in apoE4 homozygous samples but were detected in apoE3/4 heterozygotes at a level approximately 60% lower than seen in the apoE3 homozygous samples. Similar apoE3 dimers were also detected in lysates of SK-N-SH neuroblastoma cells and in freshly prepared rabbit brain homogenates. The addition of the thiol trapping agent, iodoacetamide, to block reactive thiols during both human and rabbit brain sample homogenisation and processing did not reduce the amount of apoE homodimer recovered. These data indicate that the apoE dimers we detected in the human brain are not likely to be post-mortem artefacts.</p> <p>Conclusion</p> <p>The identification of disulphide-linked apoE dimers in human cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.</p

Twisted k-graph algebras associated to Bratteli diagrams

Given a system of coverings of k-graphs, we show that the cohomology of the resulting (k+1)-graph is isomorphic to that of any one of the k-graphs in the system. We then consider Bratteli diagrams of 2-graphs whose twisted C*-algebras are matrix algebras over noncommutative tori. For such systems we calculate the ordered K-theory and the gauge-invariant semifinite traces of the resulting 3-graph C*-algebras. We deduce that every simple C*-algebra of this form is Morita equivalent to the C*-algebra of a rank-2 Bratteli diagram in the sense of Pask-Raeburn-R{\o}rdam-Sims.Comment: 28 pages, pictures prepared using tik

Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.

BACKGROUND: Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown. METHODS: In a trial of anthelminthic treatment during pregnancy in Uganda (ISRCTN32849447; http://www.controlled-trials.com/ISRCTN32849447/elliott), offspring of women with Schistosoma mansoni were examined for cytokine and antibody responses to schistosome worm (SWA) and egg (SEA) antigen, in cord blood and at age one year. Relationships to maternal responses and pre-treatment infection intensities were examined, and responses were compared between the offspring of women who did, or did not receive praziquantel treatment during pregnancy. RESULTS: Of 388 S. mansoni-infected women studied, samples were obtained at age one year from 215 of their infants. Stool examination for S. mansoni eggs was negative for all infants. Cord and infant samples were characterised by very low cytokine production in response to schistosome antigens with the exception of cord IL-10 responses, which were substantial. Cord and infant cytokine responses showed no association with maternal responses. As expected, cord blood levels of immunoglobulin (Ig) G to SWA and SEA were high and correlated with maternal antibodies. However, by age one year IgG levels had waned and were hardly detectable. Praziquantel treatment during pregnancy showed no effect on cytokine responses or antibodies levels to SWA or SEA either in cord blood or at age one year, except for IgG1 to SWA, which was elevated in infants of treated mothers, reflecting maternal levels. There was some evidence that maternal infection intensity was positively associated with cord blood IL-5 and IL-13 responses to SWA, and IL-5 responses to SEA, and that this association was modified by treatment with praziquantel. CONCLUSIONS: Despite strong effects on maternal infection intensity and maternal immune responses, praziquantel treatment of infected women during pregnancy had no effect on anti-schistosome immune responses among offspring by age one year. Whether the treatment will impact upon the offspring's responses on exposure to primary schistosome infection remains to be elucidated. TRIAL REGISTRATION: ISRCTN: ISRCTN32849447