The star formation history of RCW 36

Recent studies of massive-star forming regions indicate that they can contain multiple generations of young stars. These observations suggest that star formation in these regions is sequential and/or triggered by a previous generation of (massive) stars. Here we present new observations of the star forming region RCW 36 in the Vela Molecular Ridge, hosting a young cluster of massive stars embedded in a molecular cloud complex. In the periphery of the cluster several young stellar objects (YSOs) are detected which produce bipolar jets (HH 1042 and HH 1043) demonstrating that these objects are still actively accreting. The VLT/X-shooter spectrum of the jet structure of HH 1042 provides detailed information on the physical conditions and kinematical properties of the jet plasma. From this information the YSO's accretion history can be derived. Combining the photometric and spectroscopic observations of RCW 36 gives insight into the formation process of individual stars and the star formation history of this young massive-star forming region.Comment: 10 pages, 5 figures, to appear in the proceedings of the ESO workshop "Circumstellar Dynamics at High Resolution", Foz do Iguacu (Br), Feb 2012, eds. A. Carciofi and T. Riviniu

Massive pre-main sequence stars in M17

The formation process of massive stars is still poorly understood. Massive young stellar objects (mYSOs) are deeply embedded in their parental clouds, they are rare and thus typically distant, and their reddened spectra usually preclude the determination of their photospheric parameters. M17 is one of the best studied HII regions in the sky, is relatively nearby, and hosts a young stellar population. With X-shooter on the ESO Very Large Telescope we have obtained optical to near-infrared spectra of candidate mYSOs, identified by Hanson et al. (1997), and a few OB stars in this region. The large wavelength coverage enables a detailed spectroscopic analysis of their photospheres and circumstellar disks. We confirm the pre-main sequence (PMS) nature of six of the stars and characterise the O stars. The PMS stars have radii consistent with being contracting towards the main sequence and are surrounded by a remnant accretion disk. The observed infrared excess and the (double-peaked) emission lines provide the opportunity to measure structured velocity profiles in the disks. We compare the observed properties of this unique sample of young massive stars with evolutionary tracks of massive protostars by Hosokawa & Omukai (2009), and propose that these mYSOs near the western edge of the HII region are on their way to become main-sequence stars ($\sim 6 - 20$ $M_{\odot}$) after having undergone high mass-accretion rates (${\dot{M}_{\rm acc}} \sim 10^{-4} - 10^{-3}$ $M_{\odot}$ $\rm yr^{-1}$). Their spin distribution upon arrival at the zero age main sequence (ZAMS) is consistent with that observed for young B stars, assuming conservation of angular momentum and homologous contraction.Comment: Accepted for publication in A&A. Appendixes A and B have been truncated due to size limitations, the full version will be available on A&

VLT/X-shooter spectroscopy of the candidate black-hole X-ray binary MAXI J1659-152 in outburst

We present the optical to near-infrared spectrum of MAXI J1659-152, during the onset of its 2010 X-ray outburst. The spectrum was obtained with X-shooter on the ESO - Very Large Telescope (VLT) early in the outburst simultaneous with high quality observations at both shorter and longer wavelengths. At the time of the observations, the source was in the low-hard state. The X-shooter spectrum includes many broad (~2000 km/s), double-peaked emission profiles of H, HeI, HeII, characteristic signatures of a low-mass X-ray binary during outburst. We detect no spectral signatures of the low-mass companion star. The strength of the diffuse interstellar bands results in a lower limit to the total interstellar extinction of Av ~ 0.4 mag. Using the neutral hydrogen column density obtained from the X-ray spectrum we estimate Av ~1 mag. The radial-velocity structure of the interstellar NaI D and CaII H & K lines results in a lower limit to the distance of ~ 4 +/- 1 kpc, consistent with previous estimates. With this distance and Av, the dereddened spectral energy distribution represents a flat disk spectrum. The two subsequent 10 minute X-shooter spectra show significant variability in the red wing of the emission-line profiles, indicating a global change in the density structure of the disk, though on a timescale much shorter than the typical viscous timescale of the disk.Comment: Accepted for publication in ApJ Letter

Impaired Release of Antimicrobial Peptides into Nasal Fluid of Hyper-IgE and CVID Patients

Patients with primary immunodeficiency (PID) often suffer from frequent respiratory tract infections. Despite standard treatment with IgG-substitution and antibiotics many patients do not improve significantly. Therefore, we hypothesized that additional immune deficits may be present among these patients.To investigate if PID patients exhibit impaired production of antimicrobial peptides (AMPs) in nasal fluid and a possible link between AMP-expression and Th17-cells.Nasal fluid, nasopharyngeal swabs and peripheral blood mononuclear cells (PBMCs) were collected from patients and healthy controls. AMP levels were measured in nasal fluid by Western blotting. Nasal swabs were cultured for bacteria. PBMCs were stimulated with antigen and the supernatants were assessed for IL-17A release by ELISA.In healthy controls and most patients, AMP levels in nasal fluid were increased in response to pathogenic bacteria. However, this increase was absent in patients with common variable immunodeficiency (CVID) and Hyper-IgE syndrome (HIES), despite the presence of pathogenic bacteria. Furthermore, stimulation of PBMCs revealed that both HIES and CVID patients exhibited an impaired production of IL-17A.CVID and HIES patients appear to have a dysregulated AMP response to pathogenic bacteria in the upper respiratory tract, which could be linked to an aberrant Th17 cell response

Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study

Peer reviewe

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

THE INTERMEDIATE-MASS YOUNG STELLAR OBJECT 08576nr292: DISCOVERY OF A DISK-JET SYSTEM

We present observations of the embedded massive young stellar object (YSO) candidate 08576nr292, obtained with X-shooter and SINFONI on the ESO Very Large Telescope (VLT). The flux-calibrated, medium-resolution X-shooter spectrum (300-2500 nm) includes over 300 emission lines, but no (photospheric) absorption lines, and is consistent with a reddened disk spectrum. Among the emission lines are three hydrogen series and helium lines, both permitted and forbidden metal lines, and CO first-overtone emission. A representative sample of lines with different morphologies is presented. The Hα and Ca II triplet lines are very strong, with profiles indicative of outflow and—possibly—infall, usually observed in accreting stars. These lines include a blueshifted absorption component at ~-125 km s-1. The He I and metal-line profiles are double peaked, with a likely origin in a circumstellar disk. The forbidden lines, associated with outflow, have a single blueshifted emission component centered at -125 km s-1, coinciding with the absorption components in Hα and Ca II. SINFONI H- and K-band integral-field spectroscopy of the cluster environment demonstrates that the [Fe II] emission is produced by a jet originating at the location of 08576nr292. Because the spectral type of the central object cannot be determined, its mass remains uncertain. We argue that 08576nr292 is an intermediate-mass YSO with a high accretion rate (\dot{M}_acc \sim 10^{-6}-10-5 M sun yr-1). These observations demonstrate the potential of X-shooter and SINFONI to study in great detail an accretion disk-jet system, rarely seen around the more massive YSOs.6 pages, 4 figures, 1 appendix (11 pages), accepted for publication in ApJ Lettersstatus: publishe