16 research outputs found
Modeling the high-pressure behavior of binary mixtures of carbon dioxide+alkanols using an excess free energy mixing rule
Solubility of Thiophene + Pentane and Thiophene + Octane Binary Mixtures in Supercritical Carbon Dioxide at Temperatures from 333 to 383 K
Experimental Densities of Hexane + Benzothiophene Mixtures from (313 to 363) K and up to 20 MPa
Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy : measurements of acetaminophen solubility in a wide range of state parameters
In this work we use infrared spectroscopy to investigate solubility properties of a bioactive substance in supercritical CO2 (scCO2). By using acetaminophen as a model compound, we show that the method can provide high sensitivity that makes it possible to study solubility at small concentrations, up to 10-6 mol·L-1. This method also allows one to investigate the kinetics of the dissolution process in supercritical solvent. Our measurements at two different points of the (p, T) plane ((40 MPa, 373 K) and (40 MPa, 473 K)) have shown significant difference in the kinetic mechanisms of acetaminophen dissolution at these two states: at higher temperature the dissolution process in scCO2 has two steps: (i) "fast" step when the acetaminophen concentration in scCO2 quickly reaches (70 to 80) % of the saturation level and (ii) a subsequent "slow" step where the acetaminophen concentration slowly increases up to the saturation level. However, at lower temperature, the dissolution process has only one, "slow" step