Journal of the minutes of the Board of Trustees of the University of Mississippi, 1845-1860

This work is no thesis in the strictest sense of the term; it is a contribution. I have attempted to make an exact reproduction of the Journal of the Minutes of the Board of Trustees of the University of Mississippi, 1845-1860, and have compiled an appendix with biographical sketches of the members of the Board and Faculty

Avoiding the 'costly' crisis: Informing renal services design and delivery for Aboriginal people in rural/regional New South Wales, Australia

Australian Aboriginal people experience at least eight times the incidence of chronic kidney disease progressing to end-stage kidney disease than non-Aboriginal Australians. No previous studies in rural Australia have explored the experience of Aboriginal patients with haemodialysis or renal services delivery. Methods An Indigenist research paradigm and community based participatory research methods informed interviews conducted with 18 Aboriginal haemodialysis recipients and 29 health professionals providing treatment or care. Results ‘Family’ was the motivator for persevering with haemodialysis. Comparison of both data sets revealed significant congruence between Aboriginal and provider perspectives. A combined thematic analysis produced a supervening theme of Avoiding the ‘costly’ crisis. Four sub themes were: better screening for early detection; flexible family-focussed care; system redesign to demonstrate cultural understanding; managing patient fear of mainstream services. Institutional racism emerged as a barrier to effective care for Aboriginal renal patients. Health system redesign to meet participant’s perceptions of culturally acceptable care was the greatest challenge but with potential to improve quality of care and outcomes. Conclusion Health services need to address less than optimal services for rural Aboriginal haemodialysis patients. Addressing residual institutionalised racism and the ongoing impact of past overt racism on Aboriginal people within health services will provide more culturally competent and effective treatment and care

Immigration as a social problem

Thesis (M.A.)--Boston University, 1913. This item was digitized by the Internet Archive

An index to the first eleven volumes of Ainsworth\u27s magazine, 1842-1847, a Victorian periodical

Ainsworth\u27s Magazine: A Miscellany of Romance, General Literature, and Art made its first appearance in February, 1842. Owned and edited by William Harrison Ainsworth, illustrated by George Cruikshank, published in London by Hugh Cunningham, it was a bargin at eighteen pence. To a greater extent than any of its predecessors, Ainsoworth\u27s was a literary magazine. Previous successful monthlies had been owned by publishing houses, with literary editors at the finanical and ideological mercy of the publishers--according to the literary men. Ainswroth\u27s hope was that a plan, which invests the real property and the real responsibility of a Magaine in literary hands, may give great freedom to writers...and therefore be more favourable to the prosperous exercise of their talents, than is frequently the case under established arrangements.1 This freedom, however, was not to be licence. Although free of a publisher\u27s restrictions, this was to be a family magazine, addressed not to Mothers only, but to Daughers. 2 The necessity to preserve the virture and vacuity of the minds of these young persons was laready beginning to diminate the Victorian literary scene. Ainsworth\u27s Magazine had its initial success assured in the person of its owner-editor, William Harrison Ainsworth. By the time he undertook proprietorship of a magazine, Ainsworth had been a publisher, an editor, a contributor to the popular annuals and monthlies of the day, and had written six best-selling romances. Historical romances; sporting, domestic, and social novels; travel books; scientific and pseudoscientific studies; and biographies were among the books with wied appeal, and they were given serious consideration in the magazine. Not only the books reviewed, but the reviews themselves, are an important part of the context of the writings of the novelists and prose writers of the era to whom we give our serious consideration today

Morals and manners in Ben Jonson's comedies

Thesis (M.A.)--Boston University, 1938. This item was digitized by the Internet Archive

Using genomics, metagenomics and other omics to assess valuable microbial ecosystem services and novel biotechnological applications

Metagenomics and other "omics" are among the fastest advancing scientific tools, underpinning the recent and unprecedented access to genetic and functional information of entire communities of bacteria, virus and fungi. These remarkable advances contribute greatly to expanding our understanding of the diversity, ecology, evolution and functioning of the microbial world. There is a continuous and dynamic development of faster and cheaper sequencing and other "omics" techniques. This, combined with the development of analytical tools to deal with the exponentially increasing amount of data generated, allows access to microbial communities from a wide range of habitats and environments. The synergy between metagenomics and other ?omics? is paving the path to functional, integrative, and wider analyses including systems biology. All these new developments are increasingly contributing to the understanding of the mechanisms and processes of essential microbial ecosystem services, and to the emergence of innovative applications in many different areas.Ecosystems support life on Earth, and human existence relies heavily on ecosystem goods and services. Although only recently recognized, most of these services and goods are provided by microbial populations and communities. Many of the provisioning services (e.g. food and enzymes for industrial processes); regulating services (e.g. water quality, contamination alleviation and biological processes such as pollination and symbioses); and supporting services (e.g. nutrient cycling, agricultural production and biodiversity), are produced or mediated by microbes. Indeed, for example, many of the nitrogen cycle pathways are known to be driven by different microbial guilds. For instance, atmospheric nitrogen fixation for plant crops utilization is a microbial process, which raises agricultural productivity while decreasing the use of nitrogen fertilizers. These, when used in excess, cause water eutrophication, decrease water quality and increase the emission of the greenhouse gas N2O. Recent functional metagenomic studies have shown in freshwater relationships between the microbial nitrogen cycle and the microbial cycle of methane, another source of global warming, thus revealing the intricacy of microbial ecosystem services.A recently discovered ecosystem service performed by microbial communities is based on their ability to metabolize halogenated organic compounds. These compounds, are diverse and widespread in nature, and come from both anthropogenic and natural origins. Metagenomics has revealed a high diversity and abundance of genes encoding for halogenating and dehalogenating enzymes in soil. These discoveries are highly relevant to industrial biotechnologies and to the development of bioremediation applications.Metagenomics and other "omics" methods are also playing pivotal roles in the following areas: the development of novel antibiotics, by accessing in situ antimicrobial biosynthesis and resistance within microbiomes; the identification of new enzymes like esterases with novel properties of industrial interest; the optimization of biogas-producing microbial reactors; the understanding of the implication of microbiomes in metal corrosion processes; the prevention of microbial food spoilage, not only dependent on microbiome composition but also on the interactions between the microorganisms present naturally or as contaminants in food; the development of culture-independent surveillance of commercially available probiotics. These are only a few examples as ?omics? technologies are continuously opening new areas of research.There is virtually no limitations to the investigation of the microbial world using metagenomics, other "omics" and/or integrative approaches like systems biology. Articles in this Frontiers Topic are expected to contribute to a better understanding of microbial ecosystem services and to expand the horizon for finding and developing new and more efficient biotechnological applications.Fil: Marco, Diana Elizabeth. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Matemáticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Florence Abram. National University Of Ireland; Irland

Evaluating Preceptor Perception of Role Development and Support Initiatives in a Collaborative Bachelor of Science in Nursing Program

Background: Nurse preceptors fulfill a vital role in the success of preceptorship experiences during clinical education of nursing students in their final year of study. Literature does not provide insight on preceptors’ perceptions about whether they feel supported in their knowledge about how to guide undergraduate nursing students in complex clinical learning environments. Objectives: The purpose of this study was to explore Saskatchewan preceptors’ perceptions of their role preparation/development and support, and make recommendations to enhance preceptors’ support to ensure quality learning for preceptored nursing students. Methods: The sample comprised of registered nurses who were current or past preceptors for fourth year undergraduate students. A cross sectional study design was used. Data were gathered through Qualtrics® survey and analyzed to identify statistically significant differences in sub-scales score by demographic subgroups. Results: Significant differences were found between preceptors aged 60 years and older and those aged 30-39 years or 40-49 years on the preparation subscale. In both cases those in \u3e 60 years subgroup scored higher with medium effect sizes. In regard to the years of practice, those with 10-19 years’ experience score higher than those with 5-9 years and 20-29 years, again with medium effect sizes. Conclusion and Recommendations: Gaining understanding of preceptors’ perspectives of what they need to fulfill their role as preceptors is integral to preceptor satisfaction. Enhancing preceptor satisfaction can increase recruitment and retention of preceptors for the future. Additional faculty training and support are needed to ensure faculty and preceptors have a better understanding of their roles. There is need for further development of preceptor manuals to include relevant material for specific clinical areas, a review of evaluation documents, and increased support for younger and least experienced preceptors. Contexte : Les infirmières préceptrices jouent un rôle essentiel dans le succès des expériences de préceptorat durant la formation clinique des étudiantes en dernière année de leurs études en sciences infirmières. La littérature ne fournit aucune information sur les perceptions des préceptrices, à savoir si elles se sentent appuyées lorsqu’elles doivent guider des étudiantes de premier cycle à travers des environnements d’apprentissage clinique complexes. Objectifs : Cette étude visait à explorer les perceptions des infirmières préceptrices en Saskatchewan concernant le développement, la préparation et le soutien en lien avec leur rôle, ainsi qu’à formuler des recommandations pour améliorer le soutien offert aux préceptrices pour assurer un apprentissage de qualité aux étudiantes en sciences infirmières. Méthodes : L’échantillon était composé d’infirmières qui agissaient – ou avaient agi – à titre de préceptrice pour des étudiantes en dernière année de leur programme de premier cycle. Un devis transversal a été utilisé pour cette étude. Les données ont été recueillies au moyen d’un sondage QualtricsMD et analysées dans le but de dégager des différences statistiquement significatives dans le score des sous-échelles pour chaque sous-groupe démographique. Résultats : Sur la sous-échelle de préparation, des différences significatives ont été observées entre les préceptrices âgées de 60 ans et plus et celles âgées de 30 à 39 ou de 40 à 49 ans. Dans les deux cas, celles se trouvant dans le sous-groupe « plus de 60 ans » ont obtenu un meilleur résultat avec des tailles d’effet moyennes. En ce qui concerne les années de pratique, celles ayant de 10 à 19 ans d’expérience ont obtenu un meilleur résultat que celles ayant de 5 à 9 ou de 20 à 29 ans d’expérience. Conclusion et recommandations : Il est essentiel, pour la satisfaction des infirmières préceptrices, de mieux comprendre leurs perspectives en ce qui a trait à leurs besoins pour remplir leur rôle. Le fait d’augmenter la satisfaction des préceptrices peut contribuer favorablement à leur recrutement et leur rétention à l’avenir. Il importe d’accroître la formation et le soutien des membres du corps professoral pour assurer qu’elles ainsi que les infirmières préceptrices comprennent davantage le rôle de ces dernières. Il sera également nécessaire d’actualiser les guides des préceptrices en incluant une documentation pertinente aux domaines cliniques spécifiques, de revoir les documents d’évaluation, et de soutenir davantage les préceptrices plus jeunes et moins expérimentées

Rosette-mediating PfEMP1 variants: conservation and strain-transcending antibodies

Plasmodium falciparum malaria is one of the leading causes of child mortality worldwide, and currently there is no vaccine which confers sterilising immunity against infection. One approach to reducing the morbidity and mortality associated with P. falciparum malaria would be the development of a vaccine which targets P. falciparum virulence phenotypes, thereby protecting against the severest forms of the disease. Rosetting, where erythrocytes parasitised with P. falciparum bind to uninfected erythrocytes, is a well-established virulence phenotype that could serve as such a target. Although the major family of parasite proteins responsible for rosetting, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), displays a staggering degree of antigenic polymorphism, there is some evidence to suggest that functionally related PfEMP1 subsets are relatively conserved. Therefore, it is possible that antigenic conservation within the rosette-mediating subset of this family exists. In this thesis, I aim to determine whether rosette-mediating PfEMP1 variants are sufficiently conserved to be considered viable vaccine targets. Firstly, I used rosetting Kenyan culture-adapted P. falciparum lines to characterise four novel rosette-mediating PfEMP1 variants via var gene expression profiling, and tested the ability of recombinant protein domains from these variants to bind to uninfected erythrocytes. I then examined the relationship of the var gene sequences encoding these new variants to those of known rosetting variants. Of the four newly characterised rosetting variants, three were not characteristic of rosetting variants. One was from a PfEMP1 subset which would be predicted to bind to endothelial protein C receptor, and two had a previously uncharacterised binding phenotype. This surprising discovery suggests that multiple different subsets of PfEMP1 can mediate rosetting, and some potentially have dual binding phenotypes strongly linked to severe malaria. Secondly, I investigated the existence of naturally acquired, broadly strain-transcending antibodies to rosetting parasitised erythrocytes in individuals living in malaria endemic countries. To do this, I used a method for the elution of intact IgG from human plasma from the surface of parasitised erythrocytes and transfer to heterologous parasite lines. I found that individuals do raise strain-transcending antibodies to rosetting parasite lines, suggesting the presence of conserved epitopes. Importantly, this strain-transcending recognition was seen with allopatric plasma-parasite pairs, implying that the conserved epitopes are present in geographically diverse regions. Lastly, I set out to determine whether rosetting clinical P. falciparum isolates from Uganda are recognised by polyclonal IgG raised in rabbits to rosetting PfEMP1 variants expressed by laboratory lines derived from Southeast Asia, Central America and Kenya. To do this, I undertook a study to collect P. falciparum isolates from children with malaria attending Mbale District Hospital in eastern Uganda, and then tested these isolates for recognition with the PfEMP1 antibodies by flow cytometry. I found that some of the IgG do cross-react with certain clinical isolates, suggesting the presence of conserved epitopes, but these were not universally present in all rosetting isolates. In summary I have found that, whilst rosette-mediating PfEMP1 variants may be diverse, individuals do raise strain-transcending antibodies to rosetting PEs, and conserved epitopes can be detected on PfEMP1 variants displayed by rosetting clinical isolates. These findings suggest that several distinct PfEMP1 subsets can mediate rosetting, and that rosetting PfEMP1 variant types linked to severe malaria merit further investigation as vaccine candidates

Patient Perspectives on Medication Assisted Therapy in Vermont

Introduction. Medication-Assisted Therapy (MAT) for opioid addiction has dramatically increased in Vermont, supported by a novel statewide system that integrates specialty treatment centers ( Hubs ) with primary care office-based opioid therapy ( Spokes ). In 2010, Vermont had the highest per capita buprenorphine use in the US. Previous studies of patient perspectives of MAT have identified social barriers, rigid program rules, and concerns about withdrawal and relapse as common causes of treatment failure. Our goal was to elicit patient perspectives on barriers and enablers of successful MAT to further inform system refinement. Methods. An interview guide was developed based on previous literature as well as discussions with program leadership, staff and clinicians, and community stakeholders. Responses were organized using thematic content analysis with consensus across seven interviewers and two analysts. The interviews were conducted with 44 patients enrolled in MAT at two Hub sites in Burlington, VT in October 2016. Results. The median age of subjects was 34 years, 34% were employed at least part-time, and 72% were female. Half reported a mental health condition and 20% reported chronic pain. Barriers included transportation (25%), lack of stable housing, and stigma (41%). Enablers included feeling supported (82% felt well-supported; 52% felt supported by healthcare professionals). Subjects expressed high confidence in the treatment system and high self-efficacy for sobriety. Conclusions. Patients in MAT have complex medical, mental health, social, personal, and work lives. A comprehensive system that addresses this wide range of domains is critical to achieving optimal outcomes.https://scholarworks.uvm.edu/comphp_gallery/1245/thumbnail.jp

Investigating the Flipped Classroom Model in a High School Writing Course: Action Research to Impact Student Writing Skills and Engagement

The purpose of this action research was to evaluate the implementation of the flipped classroom model in a high school English classroom. Students are entering college and the workforce lacking the minimum writing skills needed, which may be the result of a lack of engagement throughout school. The flipped classroom model is one teaching and learning strategy that has been shown to increase student achievement, close the achievement gap, and increase student engagement and critical thinking. This study focused on three research questions: (1) How and in what ways does implementing a flipped classroom model in a high school writing course affect students’ writing quality?; (2) How and in what ways does implementing a flipped classroom model in a high school writing course affect students’ engagement?; and (3) How and in what ways does the flipped classroom model affect students’ perceptions and experiences? Data collection will incorporate an evaluative, convergent parallel mixed methods design using preintervention and postintervention writing tasks, surveys, and observations. After transcribing, reviewing, and coding the data, overlapping themes were identified. Findings revealed the flipped classroom model had a positive impact on student writing achievement, engagement, and students’ perceptions of the model on their learning. The answers to these questions along with any other themes are presented, and the general value of the model is discussed