2 research outputs found
Serumski srÄani troponin I kao biljeg srÄane degeneracije uzrokovane pokusnim trovanjem ovaca salinomicinom.
Salinomycin is an ionophore with antimicrobial properties. It is a dietary additive used as a growth promoter for ruminants and as a coccidiostat in chickens. However, over-dosage or misuse situations can lead to a series of toxic syndromes. Cardiac troponin I (cTnI) is the part of the troponin complex (I, C and T) within the sarcomere in myocardial cells that regulates contraction of the heart muscle. cTnI is released from injured myocardiocytes into circulation, so it can be a specifific biomarker in myocardial necrosis. The purpose of this study is to propose cTnI for diagnostic cardiac degeneration induced by experimental toxicosis with salinomycin in sheep. Twenty Iranian mixed breed adult female fat-tailed sheep (BW: 33.3 Ā± 3.4 kg) were used in this study. The sheep were randomly divided in to five equal groups. Group I (control) received 20 mL normal Saline. Groups II, III, IV and V were orally administered 1 mg/kg (twice a day for two days), 2, 3 and 4 mg/kg (once a day for two days) salinomycin, respectively. Following drug administration, blood samples were collected at different time intervals (2, 5, 8, 14 and 21 days) in order to determine various biochemical parameters (cTnI, CK, LDH, ALT and AST). In all groups, the heart sounds of the animals were carefully heard and electrocardiogram (ECG) was taken to determine the type of probable arrhythmia. The results illustrated a significant increase in the activity of cTnI. Numerous arrhythmias were recorded, such as: sinus tachycardia, supraventricular tachycardia, sinus arrhythmia and supraventricular premature contraction. All animals with arrhythmias showed a significant increase in the activity of cTnI. Cardiac muscle necrosis observed macroscopically on post mortem examination revealed myocardial degeneration. Overall, the results of this study indicate that cTnI may be considered as a valuable biomarker in diagnosing cardiac degeneration due to salinomycin toxicosis.Salinomicin je ionofor s antimikrobnim svojstvima. Rabi se kao dodatak hrani koji u preživaÄa ima ulogu promotora rasta, a u piliÄa ulogu kokcidiostatika. Prevelike koliÄine i pogreÅ”na uporaba salinomicina mogu dovesti do teÅ”kih sindroma trovanja. SrÄani troponin I (cTnI) je dio troponinskog kompleksa (I, C i T), unutar sarkomere srÄanih miÅ”iÄnih stanica, koji regulira kontrakcije srÄanog miÅ”iÄa. BuduÄi da se oslobaÄa iz oÅ”teÄenih miokardiocita u krvotok, cTnI može biti specifiÄan biomarker kod nekroze srÄanog miÅ”iÄa. Svrha istraživanja bila je predložiti da se cTnI primjeni u dijagnostici srÄane degeneracije uzrokovane pokusnim trovanjem ovaca salinomicinom. U istraživanje je bilo ukljuÄeno 20 odraslih, masnorepih ovaca, križanki iranskih pasmina (TM: 33,3 Ā± 3,4 kg). Ovce su metodom sluÄajnog izbora bile podijeljene u pet skupina iste veliÄine. Skupina I (kontrola) dobila je 20 mL otopine soli. Skupine II, III, IV i V dobile su oralnim putem salinomicin i to u koliÄini od 1 mg/kg (dva puta dnevno kroz dva dana), odnosno 2, 3 i 4 mg/kg (jednom dnevno kroz dva dana). Odmah nakon toga uzimani su uzorci krvi u razliÄitim vremenskim razmacima (2, 5, 8, 14 i 21 dana) s ciljem odreÄivanja razliÄitih biokemijskih pokazatelja (cTnI, CK, LDH, ALT i AST). U svim skupinama pažljivo su osluÅ”kivani srÄani tonovi i odreÄivan elektrokardiogram s ciljem otkrivanja tipa moguÄe srÄane aritmije. Rezultati pokazuju znaÄajno poveÄanje aktivnosti cTnI. Zabilježene su i mnoge aritmije kao Å”to su sinusna tahikardija, supraventrikularna tahikardija, sinusna aritmija i supraventrikularna preuranjena kontrakcija. Sve su životinje uz aritmiju oÄitovale i znaÄajno poveÄanje aktivnosti cTnI. Razudbom nakon uginuÄa makroskopski je opažena nekroza i degeneracija srÄanog miÅ”iÄa. ZakljuÄno, rezultati istraživanja pokazuju da cTnI može biti vrijedan biomarker u dijagnostici srÄane degeneracije prouzroÄene trovanjem salinomicinom