Multi-Objective Optimization of Green Transportation Operations in Supply Chain Management

Supply chain is the integration of manufacturing process where raw materials are converted into final products, then delivered to customers. Supply chains consists of two basic integrated process that interact together: (1) production and inventory and (2) distribution and logistics. Maximizing competitiveness and profitability are of the main goals of a supply chain. Accounting only for economic impacts as variable and fixed costs does not serve the main goal of the supply chain. Therefore, considering customer satisfaction measures in distribution models is essential in supply chain management. Models that addressed the three objectives simultaneously handled one of the objectives as a constraint with a certain threshold in the problem, while others used weighted utility functions to address the problem objective in deterministic environment. This thesis focuses on the multi-objective Vehicle Routing Problem (VRP) in green environment. The proposed Green VRP (GVRP) deals with three different objectives simultaneously that considers economic, environmental, and social aspects. A new hybrid search algorithm to solve the capacitated VRP is presented and validated in Chapter 2. The developed algorithm combines the evolutionary genetic search with a new local search heuristic that considers both locations and demand quantities of the nodes to be visited in routing decisions, not just the distances travelled. The algorithm is then used to solve the multi-objective GVRP in Chapter 3. The objectives of the developed GVRP model are minimizing the total transportation operations cost, minimizing the fuel consumption, and maximizing customer satisfaction. Moreover, a new overlap index is developed to measure the amount of overlap between customers’ time windows that provides an indication of how tight/constrained the problem is. The model is then adapted to consider the uncertainty in travel times, service times, and unpredictable demands of customers in Chapter 4. Pareto fronts were obtained and trade-offs between the three objectives are presented in both deterministic and stochastic forms. Furthermore, analysis of the effects of changing vehicle capacity and customer time windows relaxation are presented

Synthetic Cannabinoids : psychopharmacology, clinical aspects, and psy-chotic onset

This document is the Accepted Manuscript version of the following article: Giovanni Martinotti, Rita Santacroce, Duccio Papanti, Yasmine Elgharably, Mariya Prilutskaya, Ornella Corazza, ‘Synthetic Cannabinoids: Psychopharmacology, Clinical Aspects, and Psychotic Onset’, CNS & Neurological Disorders – Drug Targets, Vol. 16, 2017. Under embargo. Embargo end date: 13 April 2018. The published manuscript is available at EurekaSelect via: https://doi.org/10.2174/1871527316666170413101839. Published by Bentham Science.Synthetic Cannabinoids (SC) are the widest and most diffused class of Novel Psychoactive Substances. SC are chemically heterogeneous and structurally dissimilar from delta-9-tetrahydrocannabinol, being full agonists of the endocannabinoid system receptors CB1 and CB2. Desired effects include euphoria, talkativeness, feelings of joy and laughter, relaxation. With respect to cannabis, SC intake may also be associated with quicker arise of the effects, shorter duration of action, and larger levels of hangover. SC are more psychoactive than cannabis: symptoms may include a wide range of clinically relevant posi-tive, negative and cognitive psychopathological symptoms that mimic symptoms of schizophrenia. The risk of two widespread symptoms of SC intoxication, namely agitation and cardiotoxicity, exceeds this of traditional cannabis of 3.8 and 9.2 times respectively. A number of deaths have been related to SC ingestion, either on their own or in combination with other recreational drugs. Prompt and reliable in-formation available for health professionals, more specific analytic techniques, and designed preventive strategies are all required to face this unprecedented challenge.Peer reviewedFinal Accepted Versio

Improving Compost Quality for Organic Vegetable production

The aim of this research is to improve the quality of organic farm compost, in order to satisfy soil fertility status required for reasonable organic vegetable production. Field experimental trial has been conducted on ALHODA organic farm, Ismaillia Governorate, Egypt. This experiment was carried out during the summer of 2002 to study the effect of some plant and animal residues (crop residues, cow manure, chicken manure, bone meal and animal hoof) in addition to natural mineral sources (rock phosphate and orthoclase). All were piled, prepared in three different mixtures and composted for 6 months. Three treatments C1, C2 and C3 were composed of 40 % crop residues + 20 % chicken manure + 40 % cow manure (control), control + 500 kg rock phosphate + 300 kg orthoclase + 500 kg bone meal and control + 500 kg rock phosphate + 300 kg orthoclase + 200 kg animal hoof, respectively. Squash (c.v. Iskandrani) was used as a test crop in sandy soil to study the effect of these compost treatments on the plant yield and leaf nutrient concentrations as well as the nutrient contents of soil. During plant growth, effective microorganisms (EM culture) was sprayed on the plant leaf and soil as well, as a biofertilizer at a rate of 4 L / feddan separately to each treatment to enhance further composting in the soil. The experimental design of the field trial was completely randomized block design with 3 replicates, in order to facilitate the statistical analysis of the results. Data obtained revealed that treatment C3 (40 % crop residues + 20 % chicken manure + 40 % cow manure + 500 kg rock phosphate + 300 kg orthoclase + 200 kg animal hoof) was the superior one. Also, EM proved significant results with all treatments; however, C3 + EM treatment recorded the highest squash yield among all treatments (8.12 tons/fed.). Bone meal and animal hoof significantly affected the NPK and micronutrient levels in compost, plant leaves and soil. Furthermore, they caused remarkable increases in both soil salinity and organic matter level in the soil

Microbial activity and biomass and N and P availability in a saline sandy loam amended with inorganic N and lupin residues

Plant residue can be a cost effective source of N and P fertilisers, which may enhance plant growth in saline soils. Salinity and limited availability of N may limit microbial activity and thus residue decomposition N and P availability. A laboratory experiment was conducted to investigate the effects of NH4-N or NO3-N on microbial activity and biomass and N and P availability in a saline sandy loam. Three levels of salinity (EC1:5 0.21, 0.51 and 0.85 dS m-1) were imposed in the sandy loam using solutions of Na+ and Ca2+. Soil was amended with or without 2% (w/w) lupin residues (C/N ratio 15.4) or 50 μg N g-1 soil as KNO3 or (NH4)2.SO4. With no residue or inorganic N added, the concentration of available N and P remained unchanged over 45 days. Soil respiration and microbial biomass C, N and P decreased with increasing salinity, but significantly increased with residue addition. Addition of inorganic N had no significant effect, but addition of NO3-N with residue significantly increased soil respiration and microbial biomass C, N and P. Salinity had no effect on N availability and decreased P availability. Nitrogen availability was lower with addition of NH4-N, N than with NO3-N. Available N and P increased with residue addition and increased further with addition of NO3-N than with NH4-N. The greater C availability in the lupin residue amended saline sandy loam stimulated microbial activity and biomass with greater N demand, thus promoted immobilization of NO3. Hence, N and P availability increased in the saline sandy loam. © 2011 Elsevier Masson SAS.Ahmed Elgharably, Petra Marschne

Nutrient availability and wheat growth as affected by plant residues and inorganic fertilizers in saline soils.

Over 10% of the world’s land is salt affected. Salt accumulation is a major soil constraint for agricultural sustainability in arable or newly cultivated soils. As a result of salinity, soil chemical, physical and biological properties deteriorate, plant uptake of water and nutrients, particularly P, decreases and plant growth declines. Application of plant residues can enhance the activity of soil microorganisms, the availability of nutrients, including P and the plant uptake of P and growth. Such a practice can also be economically viable as it can reduce the use of P from inorganic sources, maintaining the world’s reserve of P rocks and reducing the price of fertilizers and the environmental pollution often associated with the excessive application of inorganic N and P fertilizers. Little is known about how P, with N in proper form, added from inorganic and/or residue sources can affect wheat growth in the salt affected soils with no confounding pH or sodium adsorption ratio (SAR). Increasing microbial activity, N and P availability and wheat uptake of P by application of N and P from organic and inorganic sources may improve wheat growth and hence productivity under saline conditions. The overall aim of this study was to determine ways for enhancing the activity of microorganisms and increasing the availability of N and P, the uptake of nutrients, particularly P and the growth of wheat by management of fertilization from inorganic and organic sources in saline soils. This study therefore was conducted with the following aims: 1) to investigate the relationship between salinity and P availability; 2) to assess wheat response to combined application of N and P fertilizers under saline conditions; 3) to evaluate the effect of plant residue addition on N and P availability and microbial activity in salt affected soils; 4) to determine microbial response to addition of inorganic N rate and form, and how this will affect N and P availability in a saline soil, and 5) to determine the effect of P added from inorganic fertilizer and plant residue, compared to inorganic P fertilization, on microbial biomass and wheat nutrient composition and growth in a saline soil. In saline soils, P availability can be affected by the salt type and concentration and soil texture. Three experiments were conducted to study the relationship between P availability, soil texture and salinity. The results of the first experiment in which soil was shaken with different concentrations of NaCl or CaCl2 or Na2SO4, indicated that P solubility decreased with increasing concentration of Ca2+, but was not affected by Na+ salts. In the second experiment, P availability (after 24h shaking) decreased with increasing salt concentration up to EC1:5 3.1 dS m-1, increased with increasing P addition (0, 100, 200, 400, 600, 1200, 2500 and 5000 µg P g-1 soil), and was generally higher in sandy soil than in sandy loam soil. In the third experiment (15 days incubation), it was found that P availability significantly decreased one day after P addition which was followed by a further decrease to day 5, but then remained unchanged until day 15. It can be concluded that P availability is reduced in presence of clay, and decreases with increasing concentration of salts, particularly Ca2+, and that the availability of P stabilizes in sandy and sandy loam soils within 2 weeks after addition of P from inorganic source. Increasing N or P fertilization enhanced wheat growth in salt affected soils. Therefore combined application of N and P may enhance wheat growth in saline-non sodic soils with neutral pH. Three glasshouse experiments were carried out with the aim to determine the salinity range to be used in the subsequent experiments and to test the hypothesis that combined addition of N and P fertilizers can enhance wheat growth in a sandy loam soil with low SAR and neutral pH. The first two experiments were conducted in a sandy loam salinized to EC1:5 of 0.18, 1.36, 2.00 and 2.67 dS m-1 using NaCl and CaCl2. The wheat varieties Janz and Krichauff died in all soils to which salt was added showing that these EC levels were too high. The third experiment was conducted with Krichauff in the sandy loam soil with EC1:5 0.19, 0.32, 0.49, 0.67 and 0.86 dS m-1, equivalent to ECe 2.2, 4.4, 6.7, 9.2 and 11.8 dS m-1, respectively, and with 0, 30 and 60 mg P kg-1 soil and 50, 100 and 200 mg N kg-1 soil. Salinity reduced plant dry matter at all N and P application rates. Increasing N application rates decreased growth at low and high salinity, whereas increasing P addition improved growth at all salinity levels. The highest shoot and root dry weights were obtained with 50 mg N and 60 mg P kg-1 soil. Nitrogen and P fertilization did not increase wheat growth in soil with greater than EC1:5 0.67 dS m-1, equivalent to ECe 9.2 dS m-1. Plants are known to respond differently to N form. A glasshouse experiment was carried out to assess the effect of N form (NH4 +, NO3 - or NH4NO3) added at 50, 100 and 200 mg kg-1 soil, in addition to the control (no N), on nutrient composition and growth of Krichauff in a sandy loam soil with EC1:5 0.21, 0.48 and 0.86 dS m-1, equivalent to ECe 2.8, 6.6 and 11.8 dS m-1. Increasing soil salinity decreased shoot and root dry weights and shoot macro- and micronutrient concentrations with all forms of N. At every N addition rate and with increasing N addition from N50 to N200, compared to NH4 +, the salinity of soil solution was far higher with NO3 - and lowest with NH4NO3. Shoot and root dry weights were highest with addition of 50 mg NO3-N or 100 mg NH4-N or as NH4NO3 at all salinity treatments. Concentrations of shoot P, Fe, Mn and Zn concentrations were greater with NH4 + and NH4NO3 compared to NO3 -, but concentrations of shoot K and Ca were higher with NO3 - than with NH4 + nutrition at all salinity treatments. At a given N rate, shoot and root dry weights were greatest with NH4NO3 in the saline sandy loam soil with up to EC1:5 0.67 dS m-1. Two experiments were conducted to evaluate the effect of plant residue addition on microbial activity and biomass, and N and P availability in salt affected soils. Although the same amounts of Na+ and Ca2+ salts, EC1:5 differed between tested soils due to differences between soils in clay content and water holding capacity. The first experiment aimed to assess the salinity range for microbial activity over 2 weeks in saline soils with different texture amended with glucose/nitrate (C/N ratio 16:1). The EC1:5 were 0.2, 1.26, 1.83, 2.28 and 2.99 dS m-1 in the silty loam, 0.16, 1.10, 1.98, 2.33 and 3.18 dS m-1 in the sand and 0.19, 0.82, 1.75, 2.03 and 2.79 dS m-1 in the sandy loam. Soil respiration significantly decreased with increasing salinity in the glucose/nitrate amended soils, but was not completely inhibited even at highest salinity treatment. Cumulative CO2-C increased over 2 weeks and was highest in the silty loam soil and decreased in the following order: silty loam soil < sandy loam soil < sandy soil. The second experiment was conducted to determine the effect of three different plant residues added at 2% (w/w) on microbial biomass and N and P availability over time (70 days) in saline sandy and sandy loam soils with low SAR and neutral pH. The EC1:5 was 0.21, 1.08, 1.90, 2.63 and 2.89 dS m-1 in the sand and 0.19, 0.87, 1.63, 2.32 and 2.49 dS m-1 in the sandy loam. Microbial biomass C, N and P decreased with increasing soil salinity and were highest on day 10. With residue addition, microbial biomass C and P were significantly higher in the sandy than in the sandy loam soil, whereas no significant differences were found between soils for microbial biomass P at all salinity treatments. Under all salinity treatments, compared to other residues, highest biomass N was found in canola-amended sandy loam and in lupin-amended sandy soils. With increasing soil salinity, highest microbial P was found in the sandy soil amended with lupin residue. Nitrogen availability was generally higher in the sandy soil than in the sandy loam soil, whereas the opposite was found for P availability. Compared to canola and lucerne, N and P availability were highest in lupin amended sandy and sandy loam soil. Two experiments were conducted to assess whether N addition (rate and form) can affect the microbial activity in presence of residues in a saline sandy loam soil. The first experiment aimed to evaluate the effect of N rate (0, 25, 50 and 100 mg N kg-1 soil) added as NO3 - on soil respiration over 2 weeks under non-saline conditions in presence of 2% lupin residues. The second was to determine the effect of N added at 50 mg N kg-1 soil as NH4 + or NO3 - and lupin residue added at 2 and 4% (w/w) on microbial activity and biomass and N and P availability over 45 days in a sandy loam soil with EC1:5 0.21, 0.51 and 0.85 dS m-1, equivalent to ECe 2.8, 7.0 and 11.7 dS m-1. Soil respiration and cumulative respiration were not significantly affected by N application rate over 2-week-incubation under non-saline conditions. Microbial biomass and N and P availability decreased with increasing salinity and were highest at 4% lupin residue. Soil respiration rate and cumulative CO2-C and microbial biomass C, N and P were greater with addition of 50 mg N kg-1 soil as NO3-N compared to NH4-N at every addition rate of lupin residues under saline conditions. Soil microbial biomass C, N and P were highest on day 15 and decreased over time, whereas N and P availability were lowest on day 15 and increased over time. Since addition of inorganic N and P fertilizers improved the growth of wheat (cv Krichauff) in the saline sandy loam soil at SAR 1 and neutral pH, two glasshouse experiments were conducted to determine the effects of plant residue addition on the nutrition of wheat. The first experiment was conducted under non-saline condition to determine the effect of lupin residue rate (2% and 4% w/w) on wheat growth. The second experiment was conducted under saline conditions to determine the effect of P added as lupin residue (2%) and/or KH2PO4 (0, 20 and 40 mg P kg-1 soil) with and without 50 mg N kg-1 soil added as (NH4)2.SO4 on microbial biomass, N and P availability, plant growth and nutrient composition in the saline sandy loam soil. The EC1:5 were 0.23, 0.35 and 0.51 dS m-1, equivalent to ECe 3.1, 4.8 and 7.0 dS m-1, respectively. In the first experiment under non-saline conditions, shoot dry weight was lower with addition of 4% than with 2% lupin residue with and without inorganic N. In the second experiment under saline conditions, microbial biomass C and N increased with increasing application of inorganic P, but was not as much as in presence of lupin residues. In presence of lupin residue, wheat growth increased with increasing addition of inorganic P under saline conditions. Compared to the soil with P from inorganic fertilizer and residues, inorganic P increased shoot and root dry weights and shoot P, K, Mn and Zn concentrations, but not N concentration. Addition of 50 mg inorganic N in presence of lupin residues significantly increased N and P availability and microbial biomass, but had no significant effect on wheat growth in a saline sandy loam soil. The results showed that optimal application of N and P organic and inorganic fertilizers can improve N and P availability, microbial activity and wheat growth in salt affected soils. Highest wheat dry weight was achieved by application of 60 mg P kg-1 soil in a sandy loam soil with EC1:5 0.67 dS m-1, equivalent to ECe 9.2 dS m-1. Wheat growth was also improved with application of N-NH4 + or as NH4NO3 at 100 mg N kg-1 soil. These N and P fertilization rates can potentially enhance wheat growth in the sandy loam soil with up to EC1:5 0.67 dS m-1, but with SAR 1 at neutral pH. Plant residues increased microbial activity and N and P availability in the saline soils. In the soils used here, with residue addition wheat growth was P limited due to competition with microorganisms for available P. Therefore application of residues with inorganic P is necessary to satisfy wheat requirements of N and P in the saline sandy loam soil. In the saline sandy loam soil at SAR 1 and neutral pH, application of 2% lupin residues and 40 mg KH2PO4-P kg-1 soil achieved highest microbial biomass, nutrient availability and wheat growth. However, wheat growth with these rates is not as high as with inorganic P at similar rate due to micronutrient deficiency in the saline soil with lupin residues.Thesis (Ph.D.) -- University of Adelaide, School of Earth and Environmental Sciences, 200

Hepatitis C in Egypt – Past, Present and Future

Hepatitis C viral infection is endemic in Egypt with the highest prevalence rate in the world. It is widely accepted that the implementation of mass population anti-schistosomal treatment involving administration of tartar emetic injections (between the 1950s to the 1980s) led to widespread infection. What is less well known, however, is that these schemes were implemented by the Egyptian Ministry of Health on the advice of the World Health Organisation. There has been a spectrum of treatments to target the public health disaster represented by the hepatitis C problem in Egypt: from the use of pegylated-Interferon to the recent use of direct acting antiviral drugs. Some new treatments have shown greater than 90% efficacy. However, cost is a key barrier to access of these new medicines. This is coupled with a growing population, limited resources and a lack of infection control practices which mean Egypt still faces significant disease control issues today

Impact of Variation between Assays and Reference Intervals in the Diagnosis of Endocrine Disorders

Method-related variations in the measurement of hormones and the reference intervals used in the clinical laboratory can have a significant, but often under-appreciated, impact on the diagnosis and management of endocrine disorders. This variation in laboratory practice has the potential to lead to an errant approach to patient care and thus could cause harm. It may also be the source of confusion or result in excessive or inadequate investigation. It is important that laboratory professionals and clinicians know about these impacts, their sources, and how to detect and mitigate them when they do arise. In this review article, we describe the historical and scientific context from which inconsistency in the clinical laboratory arises. Examples from the published literature of the impact of the method, reference interval, and clinical decision threshold-related discordances on the assessment and monitoring of various endocrine disorders are discussed to illustrate the sources, causes, and effects of this variability. Its potential impact on the evaluation of growth hormone deficiency and excess, thyroid and parathyroid disorders, hyperandrogenism, hypogonadism, glucocorticoid excess and deficiency, and diabetes mellitus is elaborated. Strategies for assessment and mitigation of the discordance are discussed. The clinical laboratory has a responsibility to recognise and address these issues, and although a lot has been accomplished in this area already, there remains more to be done

Wheat growth in a saline sandy loam soil as affected by N form and application rate

First published online in 2009Plant growth in saline soils may be increased by fertilisation, but little is known about the effect of different forms of N on wheat growth in soils with different salinity levels. The aim of this study was to investigate the response of wheat (Triticum aestivum L., cv Krichauff) to (NH4)2SO4 or KNO3 or NH4NO3 at 0 (N0), 50 (N50), 100 (N100) and 200 (N200) mg N kg-1 soil in a saline sandy loam. Salinity was induced using Na+ and Ca2+ salts to achieve three ECe levels, 2. 8, 6. 6 and 11. 8 dS m-1 denoted S1, S2 and S3, respectively, while maintaining a low SAR (>1). Dry weights of shoot and root were reduced by salinity in all N treatments. Addition of N significantly increased shoot and root dry weights with significant differences between N forms. Under non-saline conditions (S1), addition of NO3-N at rates higher than N50 had a negative effect, while N100 as NH4-N or NH4NO3-N increased shoot and root dry weights. At N100, shoot concentrations of N and K were higher and P, Ca, Fe, Mn, Cu and Zn were lower with NO3-N than with NH4-N nutrition. The concentration of all nutrients however fell in ranges did not appear to be directly associated with poor plant growth with NO3-N. At all N additions, calculations indicated that soil salinity was highest with N addition as NO3-N and decreased in the following order: NO3-N > NH4-N > NH4NO3-N. Addition of greater than N50 as NO3 - N, compared to NH4-N or NH4-NO3, increased soil salinity and reduced micronutrient uptake both of which likely limited plant growth. It can be concluded that in saline soils addition of 100 mg N kg-1 as NH4-N or NH4NO3-N is beneficial for wheat growth, whereas NO3-N can cause growth depression. © Springer Science + Business Media B.V. 2009.Ahmed Elgharably, Petra Marschner and Pichu Rengasam