32 research outputs found

    The "Palliative Care Quality of Life Instrument (PQLI)" in terminal cancer patients

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    BACKGROUND: This paper describes the development of a new quality of life instrument in advanced cancer patients receiving palliative care. METHODS: The Palliative Care Quality of Life Instrument incorporates six multi-item and one single-item scale. The questionnaire was completed at baseline and one-week after. The final sample consisted of 120 patients. RESULTS: The average time required to complete the questionnaire, in both time points, was approximately 8 minutes. All multi-item scales met the minimal standards for reliability (Cronbach's alpha coefficient ≥.70) either before or during palliative treatment. Test-retest reliability in terms of Spearman-rho coefficient was also satisfactory (p < 0.05). Validity was demonstrated by inter-item correlations, comparisons with ECOG performance status, factor analysis, criterion-related validation, and correlations with the Assessment of Quality of Life in Palliative Care Instrument (AQEL), and the European Organisation for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30, version 3.0). CONCLUSION: The PQLI is a reliable and valid measure for the assessment of quality of life in patients with advanced stage cancer

    Oral transmucosal fentanyl citrate in cancer pain management: a practical application of nanotechnology

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    Pain is experienced by most cancer patients and represents an important issue in the clinical setting. Breakthrough pain is a transitory flare of pain that occurs in most cancer patients on a background of otherwise controlled persistent pain. Treatment of breakthrough pain is a challenging phenomenon. Oral transmucosal fentanyl citrate (OTFC; Actiq (R), Cephalon, UK), a new opioid formulation with a unique delivery system, utilizing the advantages that nanotechnology offers, reflects the characteristics of breakthrough pain (rapid onset of action and short duration), which makes it an effective treatment to cancer patients who are already receiving opioids and continue to experience such flares of pain. Oral transmueosal fentanyl citrate is specifically developed and approved for the management of breakthrough pain in cancer patients and it has the potential to be a useful tool for clinicians

    Psychometric properties of the impact of event scale in Greek cancer patients

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    To develop the Greek version of the Impact of E vent Scale-Revised (IES-R-Gr), assess its Psychometric properties, and finally to examine the impact of cancer diagnosis to a palliative care patient sample, the IES-R was translated into Greek using the “forward-backward” procedure. It was administered twice, at one-week intervals, to 82 eligible patients with advanced cancer. Together with the IES-R-Gr scale, the patients also completed the Hospital Anxiety and Depression (HAD) Scale. Reliability was assessed in terms of internal consistency (Cronbach’s alpha coefficients) and test/retest (Spearman’s r value and Kendall’s tau-b). Construct validity was demonstrated through association with the HAD Scale, and convergence and discriminative validity and interscale correlations were also assessed. The Greek version of the IES-R had Cronbach’s alphas for the intrusion, avoidance, and hyperarousal scales of 0.72, 0.77, and 0.85, respectively. Overall test-retest reliability was satisfactory at P &lt; 0.0005. Satisfactory construct validity was supported by the correlation analysis between the IES-R-Gr subscales and anxiety and depression. Factor analysis yielded three factors, explaining 57.26% of the variance. Interscale and interitem correlations were found satisfactory at P &lt; 0.0005. These results demonstrate that the IES-R-Gr is an instrument with satisfactory psychometric properties and is a valid research tool for the impact of cancer diagnosis in advanced cancer patients

    The families evaluation on management, care and disclosure for terminal stage cancer patients

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    Abstract Background Quality of life is an important concept which is subjective and personal; what is an acceptable quality of life to one may be 'worse than death' to another. The objective of this study was to develop and validate a questionnaire to assess relatives' perceptions and attitudes towards their terminal stage cancer patients' management (information disclosure, treatment choice, hospitalization and support-communication and care) including aspects regarding end-of-life and quality-of-life decisions. Methods The final study consisted of 146 relatives of advanced terminal stage cancer patients receiving palliation, attending a Pain Relief and Palliative Care Unit. The questionnaire incorporated 6 multi-item and 7 single-item scales, and was developed following a systematic review of measures appropriate for use in palliative care settings. Results Following analysis of the 25-item scale, the questionnaire has been validated as a shortened 21-item scale consisting of 5 multi-item and 5 single-item scales. Factor analysis was based upon information disclosure, hospitalization, and support-communication demonstrating Cronbach's alpha coefficients of 0.66, 0.5 and 0.70 respectively. Average item totals and inter-item scale correlations were between 0.62–0.70, with convergent validity correlations between 0.60–0.86. The questionnaire was well accepted by all subjects with an 8–10 minute completion time. Conclusion The shortened 21-item self-assessment questionnaire may provide acceptable and valid assessment of caregiver(s)/Greek cancer patients' relatives perceptions on palliative care.</p

    Psychological distress of patients with advanced cancer - Influence and contribution of pain severity and pain interference

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    The growing interest in the psychological distress and the multidimensionality of pain in patients with cancer has been the major reason for the conduction of this study. The aims we; re to evaluate psychological distress and pain in patients with advanced cancer and the impact of pain severity and pain interference dimensions on the anxiety and depression. One hundred twenty patients with advanced cancer were surveyed at a palliative care unit in Athens, Greece. Greek versions of the Hospital Anxiety and Depression (G-HAD) scale and the Brief Pain Inventory were administered. Information concerning patients’ treatment received was acquired from the medical records, whereas physicians recorded their clinical condition. The analysis showed that significant associations were found between pain interference to “mood” and HAD-A (anxiety) (r = 0.252, P =.005) and between pain interference to “relations with other people” and HAD-A (r = 0.474, P &lt;.0005). Multiple regression analyses showed that “average pain” (P &lt;.05), pain interference’to “walking ability” (P &lt;.05), “normal work” (P &lt;.05, and “relations with other people” are significant predictors of HAD-anxiety (HAD-A) (P &lt;.0005), explaining 46.2% of total variance. For depression (HAD-D), the Greek version of the Brief Pain Inventory dimension that serve as predictor is “enjoyment of life,” as well as the demographic variables of “age,” and “gender” (P &lt;.05), explaining 22.2% of variance. Moreover, a further analysis of the pain severity and pain interference scales showed that they differentiate the anxiety of the patients with cancer. In this patient sample, pain interference and, to a lesser extent, pain severity was significantly associated with psychological distress (anxiety and pain), whereas pain interference to “walking ability,” “normal work,” and “relations with other people” was found to be more prominent and troublesome to patients’ anxiety than that to patients’ depression

    Personal growth and psychological distress in advanced breast cancer

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    Aims: the experience of posttraumatic growth following breast cancer, its association with psychological distress and the predictive value of psychological distress, sociodemographic and clinical characteristics of cancer patients in their personal growth. Methods: The Posttraumatic Growth Inventory and the Greek version of the Hospital Depression and Anxiety Scale (G-HADS) were administered to 100 breast cancer patients. Sociodemographic and clinical characteristics were recorded. Results: The analysis showed that significant associations were found between PTGI-Total patients’ age (p = 0.001), and being married (p = 0.007). Moreover, significant associations was observed between PTGI-II (”New Possibilities”) and HADS-Depression (r = -0.314, p &lt; 0.05). Multiple regression analyses showed that age is a significant predictor of PTGI-II (”New Possibilites”) (p = 0.005), PTGI-V (”Apreciation of Life”) (p = 0.0005) and PTGI-Total (p = 0.037), while marital status is a significant predictor of PTGI-Total (p = 0.009). Conclusion: Specific patients’ characteristics, such as young age and being with a partner with a partner, influence the experience of posttraumatic growth in breast cancer patients. (c) 2008 Elsevier Ltd. All rights reserved
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