Digitalization of The Transport Industry in The Context of Globalization of The World Economy

Research background: The article reveals the nature and mechanisms of the influence of the digital economy on the development of the transport industry in the world. The prerequisites for researching the problems of digitalization in the transport sector are determined by several factors. Firstly, the use of digital technologies is especially evident in the transport sector. Secondly, it is the efficiency of using the latest technological achievements that determines the competitiveness of transport companies. Purpose of the article: The aim of the study of this topic is to identify the most significant manifestations of the impact of digitalization on the transport sector, trends and the nature of this impact. Methods: The methodology of the work is to use the method of scientific abstraction, analysis of facts and observation of the real existing picture, as well as induction and deduction to determine the relationship of concepts in general to individual cases. The authors of the study identified the key components of the digitalization process of the economy, and identified those that have the greatest impact on the transport sector. The article contains an analysis of the existing experience of transport digitalization, the consequences of this process. Also in this article, the authors made their forecast for the further development of transport digitalization processes. Findings & Value added: The main result of the study was the conclusion that the objective need of the transport industry for new innovative developments is very high. The economic effect, that the introduction of transport sector digital technologies, brings, is obvious and tangible

Individual expression features of GPX2, NQO1 and SQSTM1 transcript variants induced by hydrogen peroxide treatment in HeLa cells

Abstract Pathway activity assessment-based approaches are becoming highly influential in various fields of biology and medicine. However, these approaches mostly rely on analysis of mRNA expression, and total mRNA from a given locus is measured in the majority of cases. Notably, a significant portion of protein-coding genes produces more than one transcript. This biological fact is responsible for significant noise when changes in total mRNA transcription of a single gene are analyzed. The NFE2L2/AP-1 pathway is an attractive target for biomedical applications. To date, there is a lack of data regarding the agreement in expression of even classical target genes of this pathway. In the present paper we analyzed whether transcript variants of GPX2, NQO1 and SQSTM1 were characterized by individual features of expression when HeLa cells were exposed to pro-oxidative stimulation with hydrogen peroxide. We found that all the transcripts (10 in total) appeared to be significantly individually regulated under the conditions tested. We conclude that individual transcripts, rather than total mRNA, are best markers of pathway activation. We also discuss here some biological roles of individual transcript regulation