Justification of Saponaria officinalis (S. officinalis) cultivation in the soil and climatic conditions of the Primorsky region (Russia) and analysis of saponin- containing root extracts

The purpose of this study was to explore the possibility of cultivation of soapwort (S. officinalis L.) in its singleflowered and double-flowered (var. flore pleno hort.) forms in the soil and climatic conditions of the Primorsky region (Russia); to study the effects of S. officinalis L. vegetation time on the composition and micellar properties of saponincontaining root extracts for their use as highly effective natural surfactants. The dynamics of saponin accumulation in the root as a function of cultivation time was studied. The values of surface tension and critical micelle concentration indicators of saponins and water root extracts were established for both S. officinalis L. forms and different vegetation times. The effect of various technological factors on the micellar parameters of root saponins for both S. officinalis L. types was investigated. It was found that better saponin parameters of double-flowered form of S. officinalis L. allow recommending it as a high-potential source of natural surfactants, comparable to commercial Quillaja saponins in its micellar parameters. The identified correlation between changes in the hemolytic activity of root extracts of S. officinalis L. and its vegetative stage allows expanding the sphere of their application

Иммуностимулирующая активность тритерпеновых гликозидов корней Saponaria Officinalis l

International audienceThe article research the effect of triterpene glycosides of the roots of Saponaria officinalis L. on synthesis of cytokines INFy, TNFα, IL-1ß, IL-6, IL-4 by human mononuclear cells in vitro. Authors found dose-dependent immunomodulatory effect, aimed at stimulating cellular immunity, which suggests the possibility of their use in the production of functional foods for prevention of immune diseases and prevention of food allergies.Исследовано влияние тритерпеновых гликозидов корней Saponaria officinalis L. на синтез цитокинов INFγ, TNFα, IL-1ß, IL-6, IL-4 мононуклеарными клетками человека in vitro. Установлен их дозозависимый иммуномодулирующий эффект, направленный на стимуляцию клеточного иммунитета, что предполагает возможность их использования при производстве функциональных продуктов питания для профилактики иммунных заболеваний и предотвращения пищевых аллергических реакций

Effects of Triterpene Glycosides from Saponaria officinalis on the Synthesis of Proand Anti-Inflammatory Cytokines: Влияние тритерпеновых гликозидов Saponaria oOfficinalis на синтез прои противовоспалительных цитокинов

International audienceTriterpene glycosides from Saponaria officinalis regulate the production of INF-γ, TNF-α, IL-1 β, IL-6, and IL-4, which allows one to consider them to be a promising agent to treat viral, bacterial, and other infectious diseases, traumatic, burn, and others injuries to the skin and mucosae, allergic and autoimmune diseases and syndromes and to rejuvenate the skin by enhancing its regeneration.Тритерпеновые гликозиды Saponaria officinalis регулируют продукцию INFγ, TNFα, IL-1β, IL-6, IL-4, что позволяет считать их перспективным средством для лечения вирусных, бактериальных и других инфекционных заболеваний, травматических, ожоговых и иных повреждений кожи и слизистых, аллергических, аутоиммунных заболеваний и синдромов, а также для омоложения кожи путем усиления регенерации