Self-assembled ruthenium decorated electrochemical platform for sensitive and selective determination of amisulpride in presence of co-administered drugs using safranin as a mediator

International audienc

Investigation of the thermal stability of the antihypertensive drug nebivolol under different conditions: Experimental and computational analysis

The thermal decomposition of the third-generation beta-blocker nebivolol (NEB) was investigated using thermogravimetric analysis (TG) under isothermal and non-isothermal environments, revealing important steadiness performance for the dispensation in the pharma manufacturing, expecting shelf life, and appropriate storing features. Kinetic analysis was carried out using Kissinger–Akahira–Sunose, Friedman, Flynn–Wall–Ozawa, and Starink methods. The analysis reveals that the activation energy estimated from the disintegration reactions via different techniques is unswerving with each other. Furthermore, the thermodynamic constraints (ΔH, ΔS, and ΔG) of the decomposition reaction were also estimated. A correlation between the mass spectrometry and thermal behavior of NEB has also been investigated. The study provides valuable stability data, expected shelf life, and optimal storing conditions that would help drug design and manufacturing. Density functional theory was also employed to study the possible thermodynamic dissociation channels of NEB

Selenium nanoparticles synthesized using an eco-friendly method: Dye decolorization from aqueous solutions, cell viability, antioxidant, and antibacterial effectiveness

International audienceSelenium nanoparticles (SeNPs) were fabricated using a green microwave technique in the presence of ascorbic acid. The morphological features indicated that the semi-spherical SeNPs with a diameter 8.5-22nm were configured in agglomerated spherical shapes with diameters around 0.47-0.71 μm. Furthermore, the removal of Fuchsin Basic dye from aqueous solutions was investigated upon variation of concentration of SeNPs. The degradation efficiency achieved 100 % for 10 mg of SeNPs after 34 min of visible light irradiation time. The antioxidant activity 2 was tested via DPPH radical scavenging assay and displayed that the highest scavenging capacity (311.115.72 mg/g) was achieved by SeNPs at a concentration of 106.25 mg/mL. Otherwise, the cell viability of SeNPs through human fibroblasts cell lines in-vitro was reduced to be 75.13.8 % with nanoparticle concentration around 500 μg/mL. The antibacterial activity was investigated against gram-negative and gram-positive bacteria such as Escherichia coli (E.coli), Pseudomonas aeruginosa (P. aeruginosa), Klebsiella pneumoniae (K. pneumonia), Staphylococcus aureus (S. aureus), and Bacillus subtilis (B. subtilis) bacteria after one day of exposure. It was illustrated that SeNPs did not display an activity towards Staphylococcus aureus, while it possessed the highest one against Escherichia coli with MBC of 50 ± 1.76 g/mL compared with 26 ± 0.6 g/mL for the standard antibiotic. These tremendous properties of SeNPs indicate that manipulating multifunctional nanoparticles for versatile wound and skin treatment applications is highly encouraging