Supply-side effects of the 150-hour educational requirement for CPA licensure

This study examines issues associated with professional licensure in the context of the recently implemented 150-hour educational requirement for CPA licensure. We base our hypotheses on prior professional licensure research in economics and accounting. The results show that the implementation of the requirement has been associated with a substantial decline in the number of candidates taking the CPA exam, a significant increase in the pass-rate on the exam and an overall decline in the number of successful candidates. We also find that a substantial number of candidates advanced the timing of their candidature to circumvent the requirement and that candidates migrate from states that implement the requirement to non-implementing states. Copyright Springer Science+Business Media, LLC 2006150-hour rule, Occupational licensure, CPA licensure, I21, K2, L51, M4,

Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status

Because understanding amyloid fibrillation in molecular detail is essential for development of strategies to control amyloid formation and overcome neurodegenerative disorders, increased understanding of present molecular probes as well as development of new probes are of utmost importance. To date, the binding modes of these molecular probes to amyloid fibrils are by no means adequately described or understood, and the large number of studies on Thioflavin T (ThT) and Congo Red (CR) binding have resulted in models that are incomplete and conflicting. Different types of binding sites are likely to be present in amyloid fibrils with differences in binding modes. ThT may bind in channels running parallel to the long axis of the fibril. In the channels, ThT may bind in either a monomeric or dimeric form of which the molecular conformation is likely to be planar. CR may bind in grooves formed along the β-sheets as a planar molecule in either a monomeric or supramolecular form