1 research outputs found
Serum-prostatic specific antigen level as a promising marker in infertile women with polycystic ovarian disease
Objective: To evaluate value of serum prostatic specific antigen (PSA)
as a marker for PCOS infertile women undergoing ovulation induction.
Design: A prospective clinical trial Setting: Department of obstetric
and gynecology, Suez Canal university. Materials and Methods: Eighty
four women (64 with PCOS, 20 normoovulatory as control) were evaluated
clinically and by pelvic ultrasound. Serum FSH, LH and Testosterone
were estimated at 2nd day of menses while E2 and Progesterone were
estimated at the midluteal phase using highly sensitive ELFA technique
,TPSA was estimated at both 2nd day of menses and at the midluteal
phase using the Immulite / Immulite 1000 system. Results: The study
group exhibited significant higher mean TPSA 2nd day (0.040 ng/dl)
versus (0.003 ng/dl, P=0.031) in normal control group, and also
significant higher mean TPSA midluteal (0.020 ng/dl) versus (0.002
ng/dl, P=0.022) as compared to control group. Subgroup analysis
according to response showed that responders exhibited significant
reduction in TPSA level midluteal (0.008 ng/dl) than that on 2nd day
(0.011 ng/dl, P<0.001). Conclusion: the mean serum TPSA could be
detected in high significant concentrations in the serum of PCOD
infertile women with significant decreasing concentrations after
induction of ovulation, thus TPSA can be used as a promising marker for
ovarian response in infertile women due to PCOD