7 research outputs found
Bimekizumab for the treatment of moderate-to-severe plaque psoriasis: efficacy, safety, pharmacokinetics, pharmacodynamics and transcriptomics from a phase IIa, randomized, double-blind multicentre study
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: Bimekizumab is a monoclonal antibody that selectively inhibits both interleukin (IL)-17A and IL-17F, which is currently under investigation for treatment of moderate-to-severe plaque psoriasis. Maintenance dosing every 4 weeks is well established with IL-17 inhibitors for psoriasis. Objectives: To investigate the possible dosing interval during bimekizumab maintenance therapy to maintain clear skin, to inform phase III studies. Methods: Forty-nine patients with moderate-to-severe plaque psoriasis received bimekizumab 320 mg at weeks 0/4, followed at week 16 by bimekizumab 320 mg (n = 17) or placebo (n = 32). Efficacy, safety, pharmacokinetics, immunogenicity and biopsy transcriptomic analyses were assessed to week 28. Results: At week 8, 47% of patients achieved a 100% improvement from baseline in Psoriasis Area and Severity Index (PASI 100), increasing to 57% at week 12 (8 weeks after the second dose) before decreasing. In those who received bimekizumab at week 16, PASI 100 rate increased to comparable peak levels at week 20, but reduced by week 28 to 41% (12 weeks after the third dose). The week 8 transcriptional signature observed in lesional psoriatic skin rapidly normalized to levels consistent with nonlesional skin, resulting in molecular remission. Keratinocyte-related gene products such as CXCL1 (C-X-C motif chemokine ligand 1), IL-8 (encoded by the CXCL8 gene), CCL20 (C-C motif chemokine 20), IL-36Îł and IL-17C were profoundly normalized to levels associated with nonlesional skin. Conclusions: Here, inhibition of IL-17F in addition to IL-17A resulted in rapid, deep clinical responses. Additionally, profound normalization of keratinocyte biology and the psoriatic transcriptome was observed, including normalization of both IL17 and IL23 gene expression by week 8. These data provide evidence to support evaluation of bimekizumab maintenance dosing both every 8 and every 4 weeks in phase III clinical trials
In vitro Comparative Evaluation of the Fracture Resistance of Simulated Immature Teeth reinforced with Different Apical Barriers and Obturation Combination
- Author
- Al Ansary M Day P, Duggal M, Brunton P.
- Alobaid A Cortes L, Lo J, Nguyen T, Albert J, Abu Melha AS, Lin LM, Gibbs JL.
- Andreasen J Farik B, Munksgaard E.
- Boutsioukis C Noula G, Lambrianidis T.
- Camilleri J.
- Cauwels R Pieters I, Martens L, Verbeeck R.
- Chang J Hurst T, Hart D, Estey A.
- Cobankara F Adanir N, Belli S.
- Colon P Bronnec F, Grosgogeat B, Pradelle-Plasse N.
- Cvek M.
- El-Ashry BM. Eid G Ibraheem D.
- El-Ma'aita A Qualtrough A, Watts D.
- Felippe W Felippe M, Rocha M.
- Ghose L Baghdady V, Hikmat B.
- Gomes-Filho J Rodrigues G, Watanabe S, Estrada Bernabé PF, Lodi CS, Gomes AA, Faria MD, Domingos Dos Santos A, Silos Moraes JC.
- Grecha L Malliaa B, Camilleri J.
- Han L Okiji T.
- Hemalatha H Sandeep M, Kulkarni S, Yakub SS.
- KHatibovic-ofman S Raimundo L, Zheng L, Chong L, Friedman M, Andreasen J.
- Lang H Korkmaz Y, Schneider K, Raab W.
- Laurent P Camps J, About I.
- Melo M Valle A, Pereira J, Bonachela W, Pegoraro L, Bonfante G.
- Pene J Nicholls J, Harrington G.
- Pinna L Brackett M, Lockwood PE, Huffman BP, Mai S, Cotti E, Dettori C, Pashley DH, Tay FR.
- Sarkar NK Caicedo R, Ritwik P, Moiseyeva R, Kawashima I.
- Schmoldt S Kirkpatrick T, Rutledge R, Yaccino J.
- Seto B Chung K, Johnson J, Paranjpe A.
- Stefopoulos S Tsatsas D, Kerezoudis N, Eliades G.
- Stuart C Schwartz S, Beeson T.
- Tanalp J Dikbas I, Malkondu O, Ersev H, Gungor T, Bayirli G.
- Teixeira F Teixeira E, Thompson J, Trope M.
- Torabinejad M Chivian N.
- Torabinejad M Smith P, Kettering J, Pitt Ford T.
- Tuna E Dincol M, Gencay K, Aktoren O.
- Valois C Costa ED Jr.
- Versiani M Carvalho-Junior J, Padilha M, Lacey S, Pascon E, Sousa-Neto M.
- Wang X Sun H, Chang J.
- Wilkinson K Beeson T, Kirkpatrick T.
- Yamanaka Y Shigetani Y, Yoshiba K, Yoshiba N, Okiji T.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Management of a Traumatized Open Apex Tooth with a Combination of Mineral Trioxide Aggregate Apical Plug and Platelet-rich Fibrin Apical Matrix
- Author
- Al-Jadaa A Paque F, Attin T, Zehnder M.
- Alhadainy HA Himel VT, Lee WB, El Baghdady YM.
- Alves FR Almeida BM, Neves MA, Moreno JO, Rocas IN, Siqueira JF Jr.
- Andreasen JO Hjorting-Hansen E.
- Barbosa CAM Goncalves RB, Siqueira JF, Uzeda M.
- Bargholz C.
- Bodhawani M Shenoy V, Sumanthini M.
- Danesh G Dammaschke T, Gerth HUV, Zandbiglari T, Schäfer E.
- Dohan DM Chokroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B.
- Dominguez RA Munoz L, Aznar T.
- Lemon RR.
- Matt GD Thorpe JR, Strother JM, McClanahan SB.
- Rafter M Baker M, Alves M, Daniel J, Remeikis N.
- Rafter M.
- Schmoldt SJ Kirkpatrick TC, Rutledge RE, Yaccino JM.
- Sheehy EC Roberts GJ.
- Simon S Rilliard F, Berdal A, Machtou P.
- Simonpieri A Del Corso M, Sammartino G, DohanEhrenfest DM.
- Simonpieri A Del Corso M, Sammartino G, DohanEhrenfest DM.
- Sumanthini MV Naisargi S, Malgaonkar M.
- Walton R Torabinejad M.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
A Critical Review of the Literature on Carbon Disulfide Toxicity
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- American Conference of Governmental Industrial Hygienists
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- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Pharmacometrics in Psychiatric Diseases
- Author
- A Cleton
- A Farahani
- A Hest Van
- A Karow
- A Matsui-Sakata
- A Mucci
- A Price
- A Schosser
- A Thyssen
- A Vermeulen
- A Wolff Von
- AA El Ela
- AB Nejad
- AM Wessels
- AM Wessels
- AN Vgontzas
- AS Kemp
- B Candy
- B Cusack
- B Czéh
- B Haenisch
- BA Ploeger
- BE Laurijssens
- BT Kurian
- C Barbui
- C Dolder
- C Hiemke
- C Lanni
- C Missale
- C Sehlmeyer
- CE Lau
- CH Vinkers
- CL DeVane
- CM Sherwin
- CU Correll
- DM Jonker
- DP Figgitt
- DV Iosifescu
- E Mannaert
- E Spina
- EC Lange D
- EC Lange D
- EJ Lenze
- EL Swart
- FE O’Brien
- FJ Farach
- FNCM Krijzer
- G Ma
- G Movin-Osswald
- G Racagni
- G Xi
- GB Kaplan
- H Alhaj
- H Himmerich
- H Nagayama
- H Sakurai
- H Silverman
- H Uchida
- H Uchida
- HC Whalley
- HC Whalley
- HD Yoo
- HE Pigott
- HG Bernstein
- HJ Möller
- HL Van
- I Kirsch
- I Kodish
- I Mahmood
- I Ortega
- IN Ferrier
- J Dingemanse
- J Gabrielsson
- J Haller
- J Rabinowitz
- J Stevens
- J Stevens
- J Watson
- JA Bridge
- JA Lieberman
- JH Lin
- JJ Sramek
- JL Hedlund
- JM Cloos
- JM Fahey
- JM Gerven Van
- JM Goldstein
- JR Strawn
- JS Wang
- JW Mandema
- K Venkatakrishnan
- K Weihs
- KC Schmitt
- KJ Thaler
- KL Bigos
- KN Fountoulakis
- KP Zuideveld
- KT Olkkola
- L Alphs
- L Détári
- LS Prichep
- M Ansseau
- M Aravagiri
- M Bagli
- M Bellani
- M Bourin
- M Danhof
- M Danhof
- M Danhof
- M Geldof
- M Hamilton
- M Hamilton
- M Johnson
- M Kozielska
- M Lader
- M Mula
- M Obermeier
- M Riedel
- M Walter
- MC Mauri
- MD Majewska
- ME Freeman
- MN Samtani
- MR Delgado
- MR Muscatello
- N Agarwal
- N Ben Jonathan
- N Ben Jonathan
- N Klein
- N Koen
- N Kokras
- N Sakai
- NC Andreasen
- NT Baghdady
- O Della Pasqua
- OE Della Paschoa
- P Baumann
- P Fitzgerald
- P Girardi
- P Grof
- P Seeman
- PJ Williams
- R Mandrioli
- R Mandrioli
- R Yuan
- RI Ohlsen
- RJ Fragen
- RJ Rodgers
- RL Lalonde
- RS El-Mallakh
- RT Owen
- S Albrecht
- S Kapur
- S Kasper
- S Kuperman
- S Leucht
- S Madhusoodanan
- S Miyamoto
- S Uzun
- SC Suffin
- SJ Bishop
- SJ Visser D
- SN Ghaemi
- SP Spina
- SR Grimsley
- SR Kay
- SR Marder
- TH Kruger
- TN Johnson
- U Klotz
- V Pilla Reddy
- V Pilla Reddy
- V Salvi
- W Kropf
- W Maier
- W Pitchot
- Y Feng
- Y Feng
- Y Jin
- Y Mizuno
- Z Ismail
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Visual category learning: Navigating the intersection of rules and similarity
- Author
- A Evered
- A Rozenshtein
- AB Hoffman
- AL Patalano
- B Burns
- B Roads
- BJ Meagher
- BJ Spiering
- BJ Spiering
- BU Burda
- C Mitchell
- CER Edmunds
- CG Drury
- CM Grum
- CN Wahlheim
- CW Carter
- D Zeithamova
- DGK Nelson
- DM Dwyer
- E Rosch
- EG Taylor
- EJ Higgins
- EL Jones
- EM Kok
- EM Waldron
- F Guzman-Munoz
- F Sana
- FG Ashby
- FG Ashby
- FG Ashby
- FG Ashby
- FG Ashby
- FG Ashby
- H Ebbinghaus
- H Eichenbaum
- H Eichenbaum
- HL Roediger
- I Biederman
- JC Dunn
- JD Smith
- JD Smith
- JD Smith
- JM Tangen
- JP Minda
- KH Kurtz
- LG Eglington
- LJ Sorensen
- LL Jacoby
- LR Brooks
- LR Squire
- M Baghdady
- MB Casale
- ME Lancaster
- ME Mundy
- ME Mundy
- MK Johansen
- MS Birnbaum
- MS DeCaro
- N Kornell
- N Kornell
- N Sweller
- N Zulkiply
- N Zulkiply
- N Zulkiply
- NJ Cepeda
- P Raven
- PF Carvalho
- PF Carvalho
- PF Carvalho
- PF Carvalho
- PF Carvalho
- PF Carvalho
- PPJL Verkoeijen
- R Hammer
- R Hatala
- R Sajjad
- R Shah
- RA Poldrack
- RA Poldrack
- RA Searston
- RD Melara
- RG Brown
- RL Goldstone
- RL Goldstone
- RL Goldstone
- RM Gagné
- RM Nosofsky
- RM Nosofsky
- RM Nosofsky
- S Chin-Parker
- S Chin-Parker
- S HĂ©lie
- S KĂ©ri
- S Monteiro
- SHK Kang
- SM Noh
- SW Allen
- SW Ell
- SW Ell
- SW Ell
- SW Ell
- T Palmeri
- T Yamauchi
- T Yamauchi
- T Yamauchi
- T Yamauchi
- TB Ward
- TW Maddox
- VX Yan
- VX Yan
- WR Garner
- WT Maddox
- WT Maddox
- WT Maddox
- WT Maddox
- WT Maddox
- WT Maddox
- WT Maddox
- Y Lavis
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ventricular Performance After Surgery for a Congenital Heart Defect as Assessed Using Advanced Echocardiography: From Doppler Flow to 3D Echocardiography and Speckle-Tracking Strain Imaging
- Author
- A Drighil
- A D’Andrea
- A D’Andrea
- A Grison
- A Uebing
- A Vassalos
- AD Margulescu
- AE Corno
- AE Hulst van der
- AE Hulst van der
- AE Hulst van der
- AE Hulst van der
- AE Hulst van der
- AF Corno
- AJ Teske
- AM Schroh
- Arend D. J. ten Harkel
- Arno A. W. Roest
- AT Burns
- AT Burns
- B Eyskens
- BD Soriano
- BW Eidem
- C Petko
- C Srinivasan
- CA Gomez
- CY Ho
- D Daneshvar
- DJ Kozik
- DJ Penny
- E Pettersen
- E Prifti
- E Zacharska-Kokot
- ET Wu
- F Weidemann
- FP Fernandes
- G Asimakopoulos
- G Hausdorf
- G Pacileo
- G Salvo Di
- G Tamborini
- GK Singh
- GP Diller
- GS Shirali
- H Dittmann
- H Feigenbaum
- H Geyer
- H Kim
- H Takayasu
- HB Grotenhuis
- I Adachi
- J Ding
- J Kjaergaard
- J Rhodes
- J Stark
- JA Hershenson
- JW Rossano
- K Altmann
- K Harada
- KA Marcus
- L Hui
- L Mercer-Rosa
- LB Pauliks
- Liselotte M. Klitsie
- LM Klitsie
- LM Klitsie
- LM Klitsie
- LS Shekerdemian
- M Koestenberger
- M Koestenberger
- M Olivier
- M Pascotto
- M Pawelec-Wojtalik
- M Toyono
- M Vogel
- MA Gatzoulis
- MC Farah
- MJ Geelhoed
- MJ Schuuring
- MK Friedberg
- MK Friedberg
- ML Hughes
- MM Cheung
- MV Burri
- MY Abd El Rahman
- MY Abd El Rahman
- N Dittoe
- N Sasaki
- Nico A. Blom
- NS Khoo
- P Moons
- P Morcos
- P Vignon
- PA Davlouros
- PC Frommelt
- PC Frommelt
- PK Ho
- R Dhillon
- R Krishnamurthy
- R Punn
- RL Fisk
- RM Bryant
- RM Lang
- RM Lang
- RV Williams
- S Cullen
- S Kutty
- S Kutty
- S Latifi
- SD Colan
- SL Roche
- SR Veeram Reddy
- T Luecke
- T Tekten
- TA Pedersen
- TA Quinn
- TH Marwick
- TM Hoffman
- V Tavli
- W Cui
- WB Koning de
- XJ Ma
- Y Baghdady
- YF Chen
- YF Cheung
- YF Cheung
- YQ Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study