Snow Cover Variability and Trend Over the Hindu Kush Himalayan Region Using MODIS and SRTM Data

Snow cover changes have a direct bearing on the regional and global energy and water cycles and the change in the Earth\u27s climate conditions. We studied the relatively long-term (2000–2017) altitudinal spatiotemporal changes in the coverage of snow and glaciers in one of the world\u27s largest mountainous regions, the Hindu Kush Himalayan (HKH) region, including Tibet, using remote sensing data (5 km grid resolution) from the Moderate Resolution Imaging Spectroradiometer (MODIS) on board the Terra satellite. This dataset provided a unique opportunity to study zonal and hypsographic changes in the intra-annual (accumulating season and melting season) and interannual variations in snow and glacial cover over the HKH region. The zonal and altitudinal (hypsographic) analyses were carried out for the melting season and accumulating season. The altitude-wise linear trend analysis (Pearson\u27s) of snow cover, shown as a hypsographic curve, clearly indicates a major decline in snow cover (average of 5 % or more at 100 m interval aggregates) between 4000–4500 and 5500–6000 m altitudes, which is consistent with the median trend (Theil–Sen – TS) and the monotonic trend (Mann–Kendall – MK; statistics) analysis. This analysis also revealed the regions and altitudes where major and statistically significant increases (10 % to 30 %) or decreases (−10 % to −30 %) in snow cover are identified. The extrapolation of the altitude-wise linear trend shows that it may take between ∼ 74 and 7900 years, for 3001–6000 and 6000–7000 m altitude zones respectively, for mean snow cover to decline approximately 25 % in the HKH. More detailed analysis based on longer observational records and model simulations is warranted to better understand the underlying factors, processes, and feedbacks that affect the dynamic of snow cover in HKH. These preliminary results suggest a need for continued monitoring of this highly sensitive region to climate variability and change that depends on snow as a major source of freshwater for all human activities

Intravitreal Bevacizumab (Avastin) as an Adjuvant for the Treatment of Posterior Scleritis

We report a case of posterior scleritis effectively managed with intravitreal bevacizumab. A 71-year-old woman was diagnosed with posterior scleritis. Although she was initially treated with systemic steroids, her clinical presentation deteriorated. She was then treated with a single intravitreal injection of bevacizumab and aqueous humor collection. The aqueous level of vascular endothelial growth factor prior to the intravitreal injection was 880.51 pg/mL, greater than that in the healthy control group (p < 0.001). One month later, the scleritis was completely resolved, and the patient remained stable during six months of follow-up. Intravitreal bevacizumab appears to be an effective adjuvant therapy for patients with posterior scleritis

URINARY MARKERS OF OXIDATIVE DNA DAMAGE IN TYPE 1 DIABETIC CHILDREN: RELATION TO MICROVASCULAR COMPLICATIONS

  Objective: Type 1 diabetes mellitus (T1DM) is a widespread metabolic disease, which frequently carries with it a significant impact on human health. Oxidative damage and tissue inflammation have been claimed to be a typical pathogenic component for the progression of diabetic complications. We aim in this study to explore the relation of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) (as a marker of nucleic acid oxidation) to microvascular complications in T1DM.Methods: A case–control study, enrolling 45 T1DM children and an equivalent number of healthy subjects, was performed. Full clinical examination and anthropometric measurement were performed to all subjects. Urinary assessment for 8-oxodG and albumin was done in addition to blood sampling for lipid profile and glycated Hb (HbA1c) assay. Complete ocular examination for assessment of diabetic retinopathy (DR) was also done.Results: Levels of urinary 8-oxodG, serum cholesterol, triglycerides, and low-density lipoprotein in cases were significantly higher than non-diabetics; these levels were likewise higher in uncontrolled T1DM patients in comparison with well-controlled T1DM subjects. Urinary 8-oxodG and HbA1c were significantly higher in diabetic patients with albuminuria and DR compared to patients without complications. Significant positive correlation was found between 8-oxodG with HbA1c (r=0.8, p&lt;0.01), diastolic blood pressure (DBP) (r=0.4, p=0.02), and cholesterol (r=0.4, p=0.05).Conclusion: Urinary 8-oxodG was found to be a reliable marker for assessing oxidative DNA damage in T1DM and can be used in the determination of microvascular complications related to diabetes