3-Bromo-6-nitro-1-(prop-2-yn­yl)-1H-indazole

In the title compound, C10H6BrN3O2, the indazole fused-ring system is nearly planar (r.m.s. deviation = 0.008 Å); its nitro substituent is nearly coplanar with the fused ring [dihedral angle = 4.5 (2)°]. In the crystal, adjacent mol­ecules are linked by weak acetyl­ene–nitro C—H⋯O hydrogen bonds, generating a helical chain running along the b axis

1-Allyl-3-chloro-6-nitro-1H-indazole

The indazole system in each of the two independent mol­ecules of the title compound, C10H8ClN3O2, is planar (r.m.s. deviations = 0.005 and 0.005 Å). The nitro group is coplanar with the fused-ring system [dihedral angles = 1.3 (3) and 4.8 (3) Å]

Two Stage Approaches for Modeling Pollutant Emission of Diesel Engine Based on Kriging Model

Non

Complementary medicine use among Moroccan patients with cancer: A descriptive study

tter inform his patients

A Novel Algorithm for Controlling Active and Reactive Power Flows of Electric Vehicles in Buildings and Its Impact on the Distribution Network

In the literature, many optimization algorithms were developed to control electrical loads, especially Electric Vehicles (EVs) in buildings. Despite the success of the existing algorithms in improving the power profile of charging EVs and reducing the total electricity bill of the end-users, these algorithms didn&rsquo t show significant contribution in improving the voltage profile on the network, especially with the existence of highly inductive loads. The control of the active power may not be sufficient to regulate the voltage, even if sophisticated optimization algorithms and control strategies are used. To fill the gap in the literature, we propose a new algorithm that is able to control both the active and reactive power flows using electric vehicles in buildings and homes. The algorithm is composed of two parts the first part uses optimization to control the active power and minimize the electricity bill, while the second part controls the reactive power using the bidirectional converter in the EV in a way that the voltage profile on the distribution transformer respects its limits. The new approach is validated through a comparative study of four different scenarios, (i) without EV, (ii) with EV using uncoordinated charging, (iii) with EV using coordinated charging, (iv) with EV using our proposed algorithm. Results show that our algorithm has maintained the voltage within the recommended limits, and it has minimized the peak load, the electricity cost, and the techno-economic losses on the network. Document type: Articl

Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo

Inflammation is part of the physiological response of the organism to infectious diseases caused by organisms such as bacteria, viruses, fungi, or parasites. Innate immunity, mediated by mono nuclear phagocytes, including monocytes and macrophages, is a first line of defense against infectious diseases and plays a key role triggering the delayed adaptive response that ensures an efficient defense against pathogens. Monocytes and macrophages stimu lation by pathogen antigens results in activation of different signaling pathways leading to the release of proinflammatory cyto kines. However, inflammation can also participate in the pathogenesis of several diseases, the autoimmune diseases that represent a relevant burden for human health. Dendrimers are branched, multivalent nanoparticles with a well-defined structure that have a high potential for biomedical applications. To explore new approaches to fight against the negative aspects of inflammation, we have used neutral high-generation phosphorus dendrimers bearing 48 (G3) or 96 (G4) bisphosphonate groups on their surface. These dendrimers show no toxicity and have good solubility and chemical stability in aqueous solutions. Here, we present data indicating that neutral phosphorus dendrimers show impressive antiinflammatory activities both in vitro and in vivo. In vitro, these dendrimers reduced the secretion of proinflammatory cytokines from mice and human monocyte derived macrophages. In addition, these molecules present efficient antiinflammatory activity in vivo in a mouse model of subchronic inflammation. Taken together, these data suggest that neutral G3- G4 phosphorus dendrimers have strong potential applications in the therapy of inflammation and, likely, of autoimmune diseases.info:eu-repo/semantics/publishedVersio

In vitro cytotoxic, antioxidant, hemolytic and cytoprotective potential of promising ethacrynic acid derivatives

The present study aims to screen some pharmacological activities of three promising ethacrynic acid (EA) derivatives (P3, P4, and P5) containing a piperazine moiety. The EA derivatives were tested against MDA-MB-468 cancer cell line as a model for the triple-negative breast cancer and MCF7 cancer cell line as a model subtype of luminal breast cancer using the methyl tetrazolium test (MTT). Additionally, the modulation of the glutathione and thioredoxin enzymatic systems, as well as the antioxidant and cytoprotective potential of each compound, were investigated. Moreover, initial in vitro safety screening was conducted using human blood cells. As a result, EA derivatives showed clear dose-dependent antiproliferative activity in the micromolar range (between 1.13 and 2.51 uM), with high selectivity to cancer cells by orchestrating oxidative stress. Derivative P3 has the most promising potential for further preclinical investigation, owing to its safety profile and significant cytoprotective and antitumor properties

Burning Rate Modifiers to Tailor Combustion of ADN/AN-Based Solid Propellants

This paper presents a study, carried out in the framework of the H2020 european project GRAIL, on thermal and catalytic decomposition of a solid ADN/AN mixture. Decomposition pathways of the mixture are proposed thanks to thermal analyses coupled with mass spectrometry. Thirty-four burning rate modifiers have been investigated using thermal analyses. This led to the selection of five candidates considered as promising additives: nano-CuO, CuO, Cr2Cu2O5, ZnO and ferrocene. Finally, a bicatalytic system with nano-CuO and ferrocene was considered for possible improvement of the decomposition. It prove to display a much attractive behavior towards the decomposition of this oxidizer mixture