Infrared and Thermal Analysis of Vanadyl(II) Barbiturate Complex

An usual method for the preparation of vanadyl(II) barbiturate complex was performed under the chemical reaction of vanadyl(II) sulfate with barbituric acid (H2L) and formulated as: [VO(HL)2].2H2O. This new barbiturate complex was synthesis and characterized by elemental analysis, molar conductivity, magnetic measurements, infrared spectral method and simultaneous thermal analysis (TG/DTG) techniques. The molar conductance measurements proved that barbiturate vanadyl(II) complex is non-electrolytes. The infrared spectra of the barbituric and vanadyl(II) complex are used to identify the mode of coordination. Kinetic and thermodynamic parameters (E*, ΔH*, ΔS* and ΔG*) of H2L ligand and its complex are estimated according to the DTG curves.Â

New chemical procedures for preparation of manganese(II), cobalt(II), zinc(II) and cadmium(II) carbonates under the catalytic behavior of metal ions: Discussion of infrared spectral bands

Abstract: Mn(II), Co(II), Zn(II) and Cd(II) carbonates, respectively, were achieved by a new chemical procedure under the reaction of aqueous solutions of metal ions (MnCl 2 , Co(NO 3 ) 2 , Zn(NO 3 ) 2 or CdCl 2 ), potassium iodide and urea with molar ratio 1:2:10, respectively, at ~ 90 o C for 3 hrs. The infrared spectra of the results indicate absence of the essential bands of urea, but existed of the characteristic bands of ionic carbonate, CO 3 2-. An important chemical mechanisms discussed the preparation of Mn(II), Co(II), Zn(II) and Cd(II) carbonate compounds were suggested

Infrared spectra and thermal degradation pathway of Zn(II), Cd(II) and Hg(II) alloxan diabetes adduct

Abstract: Alloxan diabetes complexes with Zn(II), Cd(II) and Hg(II) metal ions have been separated in solid form and characterized on the basis of elemental analysis, molar conductivity, mid infrared spectra. The thermal decomposition the solid complexes was studied. The ligational behavior of Cd(II) and Hg(II) occurs through the oxygen in position 2 and the nitrogen in position 1. Concerning Zn(II) complex the complexation involving the carbonyl group in position 4 (or 6) can be realized through both pyrimidine nitrogen atom and one of the hydroxyl groups in position 5. Keywords: Alloxan; Infrared spectra; thermal studies; chelation. I-INTRODUCTION Pyrimidine derivatives are known for their varied biological properties. Brugnatelli [1] was the first to isolate "Alloxan", a pyrimidine derivative in 1818 and later this compound was found to possess antineoplastic properties ISSN: 2319-8753 International Journal of Innovative Research in Science, Engineering and Technology Vol. 2, Issue 11, November 2013 Copyright to IJIRSET www.ijirset.com 6280 II-EXPERIMENTAL II-1-Materials and instrumentation All chemicals were reagent grade and were used without further purification. Alloxan was purchased from Fluka Chemical Co., ZnBr 2 , CdCl 2 and HgCl 2 (Merck Co.). Carbon, hydrogen and nitrogen contents were determined using a Perkin-Elmer CHN 2400. The metal content was found gravimetrically by converting the compounds into their corresponding oxides at 800 o C under air condition. IR spectra were recorded on Genesis II FT-IR Spectrometer in the (4000-400 cm -1 ) range with 40 scans in KBr discs. The UV-vis, spectra were determined in the DMSO solvent with concentration (1.00× 10 -3 M) for the alloxan and their complexes using Jenway 6405 Spectrophotometer with 1cm quartz cell, in the range 800-200 nm. Molar conductivities of freshly prepared 1.0×10 -3 mol/dm 3 DMSO solutions were measured using Jenway 4010 conductivity meter. Simultaneous TGA and DTA curves were obtained on a Rigaku 8150 thermoanalyser under dynamic nitrogen atmosphere, at a heating rate of 5 deg min -1 . Preparation of these two complexes followed mainly the same procedure as preparation of Zn(II) complex, but the weight of CdCl 2 and HgCl 2 were (0.201 gm, 1.0 mmol) and (0.271 gm, 1.0 mmol), respectively. The pH was adjusted at 7.5. II.2. Synthesis of metal complexes III-RESULTS AND DISCUSSION Alloxan is one of alterdentate ligand which offers metal ion more than one equivalent coordination site. In an alterdentate ligand there is, principally, always a rearrangement possible in which the metal is transferred from one site to another one. This can be either an inter-or intramolecular process. The rearrangement reaction is kinetically controlled by the activation energy and entropy experienced by the metal on the reaction path. The free energy difference is zero by definition, if the coordination sites are equivalen

Using a Modified Polyamidoamine Fluorescent Dendrimer for Capturing Environment Polluting Metal Ions Zn2+, Cd2+, and Hg2+: Synthesis and Characterizations

One of the most pressing global concerns is how to provide a clean environment for future generations given the exacerbation of urban, agricultural, industrial, and economic activities due to the escalating size of the global population. A polyamidoamine (PAMAM) dendrimer peripherally modified with 4-N,N′-dimethylethylenediamine-1,8-naphthalmide as a chromophore was synthesized and utilized to capture hazardous heavy metal ions. This modified fluorescent dendrimer (FCD) was complexed with Group 12 metal ions (Zn2+, Cd2+, and Hg2+) at a 2:1 (metal: FCD) ratio. Electronic absorption, fluorescence emission, Infra-red (IR), and nuclear magnetic resonance (1H NMR) spectroscopies, conductivity, CHN elemental, thermogravimetry, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analyses were used to characterize the resulting metal complexes. These assays revealed that the synthesized complexes were yellow-colored, thermally stable, nanoscale-sized, and composed of [M2FCD]·4Cl2. Considerable spectral shifts were observed in the emission and absorption spectra of the FCD molecule after binding the Zn2+ ions, which can be used to differentiate the Zn2+ complex from the other two complexes. This work provides basic data to facilitate the detection, quantification, and removal of environmentally hazardous heavy metal ions through complexation with a fluorescent dendrimer

Using a Modified Polyamidoamine Fluorescent Dendrimer for Capturing Environment Polluting Metal Ions Zn²⁺, Cd²⁺, and Hg²⁺: Synthesis and Characterizations

One of the most pressing global concerns is how to provide a clean environment for future generations given the exacerbation of urban, agricultural, industrial, and economic activities due to the escalating size of the global population. A polyamidoamine (PAMAM) dendrimer peripherally modified with 4-N,N′-dimethylethylenediamine-1,8-naphthalmide as a chromophore was synthesized and utilized to capture hazardous heavy metal ions. This modified fluorescent dendrimer (FCD) was complexed with Group 12 metal ions (Zn2+, Cd2+, and Hg2+) at a 2:1 (metal: FCD) ratio. Electronic absorption, fluorescence emission, Infra-red (IR), and nuclear magnetic resonance (1H NMR) spectroscopies, conductivity, CHN elemental, thermogravimetry, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analyses were used to characterize the resulting metal complexes. These assays revealed that the synthesized complexes were yellow-colored, thermally stable, nanoscale-sized, and composed of [M2FCD]·4Cl2. Considerable spectral shifts were observed in the emission and absorption spectra of the FCD molecule after binding the Zn2+ ions, which can be used to differentiate the Zn2+ complex from the other two complexes. This work provides basic data to facilitate the detection, quantification, and removal of environmentally hazardous heavy metal ions through complexation with a fluorescent dendrimer

Potential Therapeutic Effects of New Ruthenium (III) Complex with Quercetin: Characterization, Structure, Gene Regulation, and Antitumor and Anti-Inflammatory Studies (RuIII/Q Novel Complex Is a Potent Immunoprotective Agent)

The aim of this study was to evaluate the antioxidant and anti-inflammatory effects of the new [Ru(Q)(Cl)2(H2O)2] complex (RuIII/Q). A new vital complex containing quercetin flavonoid compound (Q) with ruthenium (III) ions was synthesized. The molar conductivity of the RuIII/Q complex was measured in dimethylsulfoxide (DMSO) with value 12 (Ω−1 mol−1 cm−1, indicating their non-electrolytic nature. Infrared (FTIR) spectroscopic investigation of the RuIII/Q complex indicated that Q is coordinated as a bidentate with Ru metal ions through the oxygen of carbonyl C(4)=O group and oxygen of phenolic C(3)−O group based on the wavenumber shifts at 1654 and 1335 cm−1 respectively. The electronic (UV−Vis) spectra and the magnetic susceptibility value (1.85 B.M.) revealed that the Ru(III) complex has an octahedral geometry. The average diameter of the RuIII/Q nanoparticles was approximately 7–15 nm according to the transmission electron microscopy. The thermogravimetric study (TG/DTG) indicates that the RuIII/Q compound is quite stable until 300 °C. To assess biological activity, 60 male rats were allocated to six groups, namely control, DG (D-galactose), Q, RuIII/Q, DG plus Q, and DG plus RuIII/Q. Antioxidant enzymes (SOD, CAT, GPx, and GRx), markers of lipid peroxidation (such as MDA), expression of genes (namely Nrf2, Cu-ZnSOD, CAT, GPx, cyto c, P53, Bax, BCl2, caspase-3, and caspase-9 in testicular tissue), glutamate, 4-hydroxynonenal (HNE), GSH, HCY, amyloid beta, and GABA levels were evaluated in brain tissues. Cytokines, such as IL-6 and TNF-α, histological and ultrastructural studies were estimated in both the brain and testicular tissues, while the comet assay was performed in the brain tissue. RuIII/Q administration either alone or combined with DG reduced oxidative injury to normal levels and decreased apoptotic activities. Thus, RuIII/Q inhibited injury in both the testis and brain and reduced oxidative stress in male rats. The (RuIII/Q) complex has a potent ameliorative effect against aging neurotoxicity, reproductive toxicity, and antihepatic cancer activity induced by D-galactose (DG)

Quercetin/Zinc complex and stem cells: A new drug therapy to ameliorate glycometabolic control and pulmonary dysfunction in diabetes mellitus: Structural characterization and genetic studies.

Medicinal uses and applications of metals and their complexes are of increasing clinical and commercial importance. The ligation behavior of quercetin (Q), which is a flavonoid, and its Zn (II) (Q/Zn) complex were studied and characterized based on elemental analysis, molar conductance, Fourier-transform infrared (FTIR) spectra, electronic spectra, proton nuclear magnetic resonance (1H-NMR), thermogravimetric analysis, and transmission electron microscopy (TEM). FTIR spectral data revealed that Q acts as a bidentate ligand (chelating ligand) through carbonyl C(4) = O oxygen and phenolic C(3)-OH oxygen in conjugation with Zn. Electronic, FTIR, and 1H-NMR spectral data revealed that the Q/Zn complex has a distorted octahedral geometry, with the following chemical formula: [Zn(Q)(NO3)(H2O)2].5H2O. Diabetes was induced by streptozotocin (STZ) injection. A total of 70 male albino rats were divided into seven groups: control, diabetic untreated group and diabetic groups treated with either MSCs and/or Q and/or Q/Zn or their combination. Serum insulin, glucose, C-peptide, glycosylated hemoglobin, lipid profile, and enzymatic and non-enzymatic antioxidant levels were determined. Pancreatic and lung histology and TEM for pancreatic tissues in addition to gene expression of both SOD and CAT in pulmonary tissues were evaluated. MSCs in combination with Q/Zn therapy exhibited potent protective effects against STZ induced hyperglycemia and suppressed oxidative stress, genotoxicity, glycometabolic disturbances, and structural alterations. Engrafted MSCs were found inside pancreatic tissue at the end of the experiment. In conclusion, Q/Zn with MSC therapy produced a synergistic effect against oxidative stress and genotoxicity and can be considered potential ameliorative therapy against diabetes with pulmonary dysfunction, which may benefit against COVID-19