A VILLAGE IN INDIA: AN APPLICATION OF THE THEORY OF INCREASING SCALE OF SOCIETAL ORGANIZATION

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Improved ultrasonic standard reference blocks

A program to improve the quality, reproducibility and reliability of nondestructive testing through the development of improved ASTM-type ultrasonic reference standards is described. Reference blocks of aluminum, steel, and titanium alloys were considered. Equipment representing the state-of-the-art in laboratory and field ultrasonic equipment was obtained and evaluated. Some RF and spectral data on ten sets of ultrasonic reference blocks were taken as part of a task to quantify the variability in response from nominally identical blocks. Techniques for residual stress, preferred orientation, and microstructural measurements were refined and are applied to a reference block rejected by the manufacturer during fabrication in order to evaluate the effect of metallurgical condition on block response

The Missing Safety Net and Families: A Progressive Critique of the New Welfare Legislation

This is an overview essay on the 1996 welfare legislation and its consequences. The paper is divided into five parts: (1) The basic elements of the legislation; (2) The conservative assumptions undergirding this legislation and the progressive responses to them; (3) The consequences of the legislation for individuals and families; (4) The missing elements in the new welfare legislation; and (5) The progressive solution to welfare

Acoustic Emission Source Characterization Through Direct Time-Domain Deconvolution

While detected acoustic emission (AE) signals contain potentially useful information about the deformation source mechanisms of a structure under load, signal processing techniques such as threshold counting, RMS recording, energy measurement, peak detection, and spectral analysis often fail to extract such information unambiguously. The difficulty lies both in the inherent complexity of the deformation mechanism and in the lack of understanding of the source mechanism, the wave propagation details, and the physics of the sensor\u27s mechanical-to-electrical conversion process. Instead of taking an empirical approach to establish the correlations between the detected AE and the observed possible deformation mechanism, we approach the problem by constructing a simple test system which consists of three main ingredients: a true displacement sensor (capacitive transducer), a simple structure (either a large block or a plate), and known theoretical impulse-response functions for specific sensor-source relative locations. We first establish the validity of these ingredients by testing with simulated AE of known step-function time dependency generated by breaking glass capillaries. Unknown sources are then introduced, one at a time, into the system for determination of their time functions. The time function at the source is determined by a deconvolution process from the known impulse response and the detected displacement. Furthermore, we show the existence of the inverse of the impulse-response function with respect to convolution for at least two extreme cases. Consequently, the source function can be obtained simply by convolving the detected signal with the inverse function. Applications to AE system calibration, sensor characterization, wave propagation studies, and brittle crack opening signature analysis will be demonstrated

A Basis for Traceable NDE Standards

The National Bureau of Standards (NBS) is beginning to provide a mechanism for traceability for a number of NDE measurement procedures, an activity that is expected to have a significant, positive impact on the reproducibility and accuracy of NDE measurements. Much of the NDE standards activity has been in ultrasonics and acoustic emission, this effort leading to calibration services for ultrasonic reference blocks and ultrasonic and acoustic emission transducers. Additional NDE standards are also available or are being developed in radiography, eddy currents, magnetic particles, liquid penetrants and visual testing

Improved ultrasonic standard reference blocks

A program to improve the quality, reproducibility and reliability of nondestructive testing through the development of improved ASTM-type ultrasonic reference standards is described. Reference blocks of aluminum, steel, and titanium alloys are to be considered. Equipment representing the state-of-the-art in laboratory and field ultrasonic equipment was obtained and evaluated. RF and spectral data on ten sets of ultrasonic reference blocks have been taken as part of a task to quantify the variability in response from nominally identical blocks. Techniques for residual stress, preferred orientation, and micro-structural measurements were refined and are applied to a reference block rejected by the manufacturer during fabrication in order to evaluate the effect of metallurgical condition on block response. New fabrication techniques for reference blocks are discussed and ASTM activities are summarized

Proteomic analysis of secretagogue-stimulated neutrophils implicates a role for actin and actin-interacting proteins in Rac2-mediated granule exocytosis

<p>Abstract</p> <p>Background</p> <p>Neutrophils are abundant leukocytes that play a primary role in defence against pathogens. Neutrophils enter sites of infection where they eliminate pathogens via phagocytosis and the release of antimicrobial mediators via degranulation. Rho GTPases, particularly Rac2, play a key role in neutrophil degranulation. The purpose of this study was to identify Rac2-dependent changes in protein abundance in stimulated neutrophils.</p> <p>Methods</p> <p>We performed a proteomic analysis on secretagogue-stimulated bone marrow neutrophils that were isolated from wild-type and Rac2^-/-mice. Protein abundance was analyzed by 2-dimensional SDS-PAGE of fluorescently labelled samples which allowed the detection ~3500 proteins.</p> <p>Results</p> <p>We identified 22 proteins that showed significant changes in abundance after secretagogue-stimulation of wild-type neutrophils, which did not occur in neutrophils isolated from Rac2^-/-mice. As expected, the abundance of several granule proteins was reduced in wild-type cells; this did not occur in Rac2^-/-neutrophils which confirms the requirement for Rac2 in degranulation. We also found changes in abundance of many actin remodelling proteins including coronin-1A, β-actin and the F-actin capping protein, (CapZ-β). Coronin-1A showed elevated levels of several isoforms after stimulation of neutrophils from wild-type, but not from Rac2^-/-mice. These isoforms were immunoreactive with anti-phospho-threonine antibodies, suggesting that neutrophil stimulation triggers a Rac2-dependent kinase cascade that results in the phosphorylation of coronin-1A.</p> <p>Conclusion</p> <p>The control of Rac2-mediated degranulation in neutrophils likely functions through actin remodelling via activation of several actin-binding proteins. We found coronin-1A to be a novel downstream effector protein of this pathway that is threonine phosphorylated in response to secretagogue stimulation.</p

Pex3 peroxisome biogenesis proteins function in peroxisome inheritance as class V myosin receptors

Pex3 links peroxisome formation and inheritance. By binding to class V myosin, biogenesis protein Pex3 also directs the organelles into daughter cells