A Numerical Analysis of Line Equations Considering Corona Loss on a Single-Conductor System and Its Application

In this paper, the authors introduce a new digital analysis of the attenuation and distortion of the travelling waves caused by corona discharge on a singleconductor system, which is founded on their surge analyser considering corona loss. Then, applying their theory to the subject of the transient voltage rise of the transmission towers due to lightning stroke on the overhead ground wire, they numerically analyse the subject by a digital computer and discuss the influences of the corona loss on the wire to the tower voltages

Differential Signal Balancer Embedded in Silicon LSI with Bifilar Coupling Inductors and Stacked Delay Lines

The differential signal balancer, a new principle common mode filter that uses a delay line technology, is embedded in the metal wiring layer of silicon LSI with a small area of 100 μm by 230 μm. To increase the capability of the common mode noise reduction, a series resistance in the internal inductor is reduced by configured with bifilar winding. The noise reduction capability is verified in the circuit simulation including the influences of the ESD diode.2021 International Conference on Solid State Devices and Materials (SSDM2021), September 6–9, 2021, ALL-VIRTUAL conferenc

The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning

BACKGROUND: Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive. In this report, we describe roles of the NuA4 acetyltransferase and histone H4 acetylation in replication fork protection in the fission yeast Schizosaccharomyces pombe. RESULTS: Downregulation of NuA4 subunits renders cells highly sensitive to camptothecin, a compound that induces replication fork breakage. Defects in NuA4 function or mutations in histone H4 acetylation sites lead to impaired recovery of collapsed replication forks and elevated levels of Rad52 DNA repair foci, indicating the role of histone H4 acetylation in DNA replication and fork repair. We also show that Vid21 interacts with the Swi1-Swi3 replication fork protection complex and that Swi1 stabilizes Vid21 and promotes efficient histone H4 acetylation. Furthermore, our genetic analysis demonstrates that loss of Swi1 further sensitizes NuA4 and histone H4 mutant cells to replication fork breakage. CONCLUSION: Considering that Swi1 plays a critical role in replication fork protection, our results indicate that NuA4 and histone H4 acetylation promote repair of broken DNA replication forks

15-Deoxy-Δ12,14 Prostaglandin J2 Reduces the Formation of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice

AIM: 15-deoxy-Δ¹²,¹⁴ prostaglandin J₂ (15d-PGJ₂) is a ligand of peroxisome proliferator-activated receptor γ (PPARγ) having diverse effects such as the differentiation of adipocytes and atherosclerotic lesion formation. 15d-PGJ₂ can also regulate the expression of inflammatory mediators on immune cells independent of PPARγ. We investigated the antiatherogenic effect of 15d-PGJ₂. METHODS: We fed apolipoprotein (apo) E-deficient female mice a Western-type diet from 8 to 16 wk of age and administered 1 mg/kg/day 15d-PGJ₂ intraperitoneally. We measured atherosclerotic lesions at the aortic root, and examined the expression of macrophage and inflammatory atherosclerotic molecules by immunohistochemical and real-time PCR in the lesion. RESULTS: Atherosclerotic lesion formation was reduced in apo E-null mice treated with 15d-PGJ₂, as compared to in the controls. Immunohistochemical and real-time PCR analyses showed that the expression of MCP-1, TNF-α, and MMP-9 in atherosclerotic lesions was significantly decreased in 15d-PGJ₂ treated mice. The 15d-PGJ₂ also reduced the expression of macrophages and RelA mRNA in atherosclerotic lesions. CONCLUSION: This is the first report 15d-PGJ₂, a natural PPARγ agonist, can improve atherosclerotic lesions in vivo. 15d-PGJ₂ may be a beneficial therapeutic agent for atherosclerosis

エンドウの分枝性に関する研究

京都大学0048新制・論文博士農学博士論農博第81号新制||農||40(附属図書館)学位論文||S40||N120(農学部図書室)888(主査)教授 塚本 洋太郎, 教授 小林 章, 教授 今村 駿一郎学位規則第5条第2項該当Kyoto UniversityDA