Exceptional-point-based optical amplifiers

The gain-bandwidth product is a fundamental figure of merit that restricts the operation of optical amplifiers. Here, we introduce a design paradigm based on exceptional points, which relaxes this limitation and allows for the building of a new generation of optical amplifiers that exhibits a better gain-bandwidth scaling. Additionally, our results can be extended to other physical systems such as acoustics and microwaves

Nonuniversality of quantum noise in optical amplifiers operating at exceptional points

The concept of exceptional points-based optical amplifiers (EPOAs) has been recently proposed as a new paradigm for miniaturizing optical amplifiers while simultaneously enhancing their gain-bandwidth product. While the operation of this new family of amplifiers in the classical domain provides a clear advantage, their performance in the quantum domain has not yet been evaluated. Particularly, it is not clear how the quantum noise introduced by vacuum fluctuations will affect their operation. Here, we investigate this problem by considering three archetypal EPOA structures that rely either on unidirectional coupling, parity-time symmetry, or particle-hole symmetry for implementing the exceptional point. By using the Heisenberg-Langevin formalism, we calculate the added quantum noise in each of these devices and compare it with that of a quantum-limited amplifier scheme that does not involve any exceptional points. Our analysis reveals several interesting results: most notably that while the quantum noise of certain EPOAs can be comparable to those associated with conventional amplifier systems, in general the noise does not follow a universal scaling as a function of the exceptional point but rather varies from one implementation to another

Nonuniversality of quantum noise in optical amplifiers operating at exceptional points

The concept of exceptional points-based optical amplifiers (EPOAs) has been recently proposed as a new paradigm for miniaturizing optical amplifiers while simultaneously enhancing their gain-bandwidth product. While the operation of this new family of amplifiers in the classical domain provides a clear advantage, their performance in the quantum domain has not yet been evaluated. Particularly, it is not clear how the quantum noise introduced by vacuum fluctuations will affect their operation. Here, we investigate this problem by considering three archetypal EPOA structures that rely either on unidirectional coupling, parity-time symmetry, or particle-hole symmetry for implementing the exceptional point. By using the Heisenberg-Langevin formalism, we calculate the added quantum noise in each of these devices and compare it with that of a quantum-limited amplifier scheme that does not involve any exceptional points. Our analysis reveals several interesting results: most notably that while the quantum noise of certain EPOAs can be comparable to those associated with conventional amplifier systems, in general the noise does not follow a universal scaling as a function of the exceptional point but rather varies from one implementation to another

Nonuniversality of quantum noise in optical amplifiers operating at exceptional points

The concept of exceptional points-based optical amplifiers (EPOAs) has been recently proposed as a new paradigm for miniaturizing optical amplifiers while simultaneously enhancing their gain-bandwidth product. While the operation of this new family of amplifiers in the classical domain provides a clear advantage, their performance in the quantum domain has not yet been evaluated. Particularly, it is not clear how the quantum noise introduced by vacuum fluctuations will affect their operation. Here, we investigate this problem by considering three archetypal EPOA structures that rely either on unidirectional coupling, parity-time symmetry, or particle-hole symmetry for implementing the exceptional point. By using the Heisenberg-Langevin formalism, we calculate the added quantum noise in each of these devices and compare it with that of a quantum-limited amplifier scheme that does not involve any exceptional points. Our analysis reveals several interesting results: most notably that while the quantum noise of certain EPOAs can be comparable to those associated with conventional amplifier systems, in general the noise does not follow a universal scaling as a function of the exceptional point but rather varies from one implementation to another

On-chip non-reciprocal optical devices based on quantum inspired photonic lattices

We propose a novel geometry for integrated photonic devices that can be used as isolators and polarization splitters based on engineered photonic lattices. Starting from optical waveguide arrays that mimic Fock space representation of a non-interacting two-site Bose Hubbard Hamiltonian, we show that introducing magneto-optic nonreciprocity to these structures leads to a superior optical isolation performance. In the forward propagation direction, an input TM polarized beam experiences a perfect state transfer between the input and output waveguide channels while surface Bloch oscillations block the backward transmission between the same ports. Our analysis indicates a large isolation ratio of 75 dB after a propagation distance of 8 mm inside seven coupled waveguides. Moreover, we demonstrate that, a judicious choice of the nonreciprocity in this same geometry can lead to perfect polarization splitting.Comment: 13 pages 3 figure

Robustness of spatial Penning trap modes against environment-assisted entanglement

The separability of the spatial modes of a charged particle in a Penning trap in the presence of an environment is studied by means of the positive partial transpose (PPT) criterion. Assuming a weak Markovian environment, described by linear Lindblad operators, our results strongly suggest that the environmental coupling of the axial and cyclotron degrees of freedom does not lead to entanglement at experimentally realistic temperatures. We therefore argue that, apart from unavoidable decoherence, the presence of such an environment does not alter the effectiveness of recently suggested quantum information protocols in Penning traps, which are based on the combination of a spatial mode with the spin of the particle.Comment: 11 pages, 2 figure

Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801

© 2020 by The American Society of Hematology. Acutemyeloid leukemia (AML)witheither t(8;21)(q22;q22)or inv(16)(p13q22)/t(16;16)(p13;q22) is referred to as core binding factor (CBF) AML. Although categorized as favorable risk, long-term survival for these patients is only ∼50% to 60%. Mutated (mut) or overexpressed KIT, a gene encoding a receptor tyrosine kinase, has been found almost exclusively in CBF AML and may increase the risk of disease relapse. We tested the safety and clinical activity of dasatinib, a multi-kinase inhibitor, in combination with chemotherapy. Sixty-one adult patients with AML and CBF fusion transcripts (RUNX1/RUNX1T1 or CBFB/MYH11) were enrolled on Cancer and Leukemia Group B (CALGB) 10801. Patients received cytarabine/daunorubicin induction on days 1 to 7 and oral dasatinib 100 mg/d on days 8 to 21. Upon achieving complete remission, patients received consolidation with high-dose cytarabine followed by dasatinib 100 mg/d on days 6 to 26 for 4 courses, followed by dasatinib 100 mg/d for 12 months. Fifteen (25%) patients were older (aged ≥60 years); 67% were CBFB/MYH11-positive, and 19% harbored KITmut. There were no unexpected or dose-limiting toxicities. Fifty-five (90%) patients achieved complete remission. With a median follow-up of 45 months, only 16% have relapsed. The 3-year disease-free survival and overall survival rates were 75% and 77% (79% and 85% for younger patients [aged \u3c60 \u3eyears], and 60% and 51% for older patients). Patients with KITmut had comparable outcome to those with wild-type KIT (3-year rates: Disease-free survival, 67% vs 75%; overall survival, 73% vs 76%), thereby raising the question of whether dasatinib may overcome the negative impact of these genetic lesions