Unraveling the role of local ablative therapies for patients with metastatic soft tissue sarcoma – a retrospective multicenter study of the Bavarian university hospitals

Background Local ablative therapies (LAT) are increasingly used in patients with metastatic soft tissue sarcoma (STS), yet evidence-based standards are lacking. This study aimed to assess the impact of LAT on survival of metastatic STS patients and to identify prognostic factors. Methods In this retrospective multicenter study, 246 STS patients with metastatic disease who underwent LAT on tumor board recommendation between 2017 and 2021 were analyzed. A mixed effects model was applied to evaluate multiple survival events per patient. Results Median overall survival (OS) after first metastasis was 5.4 years with 1-, 2- and 5-year survival rates of 93.7, 81.7, and 53.1%, respectively. A treatment-free interval ≥12 months and treatment of liver metastases were positively correlated with progression-free survival (PFS) after LAT (HR=0.61, p=0.00032 and HR=0.52, p=0.0081, respectively). A treatment-free interval ≥12 months and treatment of metastatic lesions in a single organ site other than lung and liver were positive prognostic factors for OS after first LAT (HR=0.50, p=0.028 and HR=0.40, p=0.026, respectively) while rare histotypes and LAT other than surgery and radiotherapy were negatively associated with OS after first LAT (HR=2.56, p=0.020 and HR=3.87, p=0.025). Additional systemic therapy was independently associated with a PFS benefit in patients ≤60 years with ≥4 metastatic lesions (for max. diameter of treated lesions ≤2cm: HR=0.32, p=0.02 and >2cm: HR=0.20, p=0.0011, respectively). Conclusion This multicenter study conducted at six German university hospitals underlines the value of LAT in metastatic STS. The exceptionally high survival rates are likely to be associated with patient selection and treatment in specialized sarcoma centers

Jus Patrimonii Dividui Et Individui academica interpretatione expositum : Præside D. Johanne Eisenhart in Academia Julia Antecessore Primario Et Facultat. Jurid. Hodie Decano Dn. Parente Suo Venerando placido eruditorum examini sistit Johan. Burchard Eisenhart Auctor. d. XXIII. Decembris M DCCV. In Novi Julei Auditorio Majori

Vorlageform des Erscheinungsvermerks: HELMSTADII Typis Georg-VVolffgangi Hammii, Acad. Typogr.Text überw. lat., teilw. auch dt.Helmstedt, Univ., Diss., 23. Dez. 170

D. Johannis Eisenharti In Academia Helstadiensi Qvondam Ivris Antecessoris Primarii Et Facvlt. Ivrid. Senioris Processvs Instantiae Restitvtionis In Integrvm Adversvs Qvorvmvis Ivdicvm Sententias Et Derceta Ex Antiqvo Et Novo Ivre, Ac Tvm Svpremi Germaniae Cameralis Ivdicii Decretis, Tvm Provincialivm Ivdiciorvm Ordinationibvs Repetita Descriptio.

Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Halae Et Helmstadii Impensis Caroli Herm. Hemmerde. MDCCLXXX

Johann. Eisenhart JCti Commentatio De Retractv Territoriali Vvlgo Marcklosung

Erschien zuerst als Jur. Diss., Helmstedt 1707Fingerprint nach Ex. der HAB Wolfenbüttel und der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Helmstadii Ex Officina Schnorriana. M DCC LII

Dissertatio Juris Feudalis De Servitiis Vasallorum Militaribus Vulgo Ritter-Diensten, Ritter-Pferden

Helmstedt, Univ., Jur. Diss., 1706Qvam ... Præside Georgio Engelbrecht Jvrivm Doctorando Eorvmqve Vt Et Moralivm In Hac Illvstri Jvlia Professore Pvblico Et ORdinario ... A. D. IV. Septemb. A. M DCCVI. ... Submittet Rvdolphvs Avgvstvs Blvme Brvnsvicensis A. & R.Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Helmestadi[i] Typis Georg-VVolfgangi Hammi[i], Acad. Typogr

Dissertatio Philosophica De Poenis

Quam ... Praeside ... Johanne Eisenhart I.U.D. ... Publico examini subiiciet die XVI. Iulii Georgius Grund Stadensis. A. & RespondensAlternativer Fingerprint (ohne [2] Bl. franz. Brief an den Vater und "Nobilissimo huius Dissert. Auctori ..."): r-on u-am inli gaca C 1681RVorlageform des Erscheinungsvermerks: Helmestadi[i], Typis Haeredum Henrici Davidis Mülleri. Acad. Typ. Anno MDCLXXXI