Determining Structurally Identifiable Parameter Combinations Using Subset Profiling

Identifiability is a necessary condition for successful parameter estimation of dynamic system models. A major component of identifiability analysis is determining the identifiable parameter combinations, the functional forms for the dependencies between unidentifiable parameters. Identifiable combinations can help in model reparameterization and also in determining which parameters may be experimentally measured to recover model identifiability. Several numerical approaches to determining identifiability of differential equation models have been developed, however the question of determining identifiable combinations remains incompletely addressed. In this paper, we present a new approach which uses parameter subset selection methods based on the Fisher Information Matrix, together with the profile likelihood, to effectively estimate identifiable combinations. We demonstrate this approach on several example models in pharmacokinetics, cellular biology, and physiology

Ground State Spin Structure of Strongly Interacting Disordered 1D Hubbard Model

We study the influence of on-site disorder on the magnetic properties of the ground state of the infinite U 1D Hubbard model. We find that the ground state is not ferromagnetic. This is analyzed in terms of the algebraic structure of the spin dependence of the Hamiltonian. A simple explanation is derived for the 1/N periodicity in the persistent current for this model.Comment: 3 pages, no figure

Projection of two biphoton qutrits onto a maximally entangled state

Bell state measurements, in which two quantum bits are projected onto a maximally entangled state, are an essential component of quantum information science. We propose and experimentally demonstrate the projection of two quantum systems with three states (qutrits) onto a generalized maximally entangled state. Each qutrit is represented by the polarization of a pair of indistinguishable photons - a biphoton. The projection is a joint measurement on both biphotons using standard linear optics elements. This demonstration enables the realization of quantum information protocols with qutrits, such as teleportation and entanglement swapping.Comment: 4 pages, 3 figures, published versio