<b>Background characteristics of the 93 travelers with dengue.</b>

<p>The median age of patients was 37 years (interquartile range: 28 to 45 years).</p>a<p>Data missing for two patients.</p>b<p>Data missing for one patient.</p

Kinetics of diagnostic combinations.

<p>The solid lines and shaded areas provide the predicted probabilities and their 95% confidence intervals for at least one of the two diagnostic tests showing a positive result on a given day of illness. Non-solid lines indicate the predicted probabilities of positive result for each test alone. The circles illustrate time points of samples negative in both tests, the size of the circle being proportional to the number of observations.</p

Kinetics of diagnostic markers.

<p>Relative amounts (A–D) and the probability of a positive result (E–H) of DENV-RNA, NS1 protein, and DENV specific IgM and IgG antibodies in the serum samples of 93 patients with acute dengue fever. Solid lines indicate predicted means (A–D), and probabilities (E–H) from generalized additive mixed models (GAMM), and dashed lines their 95% confidence intervals. In A–D, the circles serve to illustrate individual observations; in E–H, the circles show the positive/negative test results at each given time point, the size of the circle being proportional to the number of observations.</p

<b>Clinical characteristics of the 93 travelers with dengue.</b>

a<p>Reference values for males/females in parentheses.</p>b<p>At least once during the 21 days since illness onset. The timing of serum sampling was not standardized.</p>c<p>Selection criterion for entering the study.</p>d<p>Diagnosed according to current practice.</p>e<p>Of these patients, 9/17 (53%) were positive for PCR or NS1 at some point. The patients negative for PCR and NS1 provided samples on illness days 6–21.</p>f<p>Duration of hospitalization: median 4 days, interquartile range 3 to 6 days.</p><p>Abbreviations: ALT, alanine transaminase; AST, aspartate transaminase; DENV, dengue virus; Hb, hemoglobin; Hcr, hematocrit.</p