Pengembangan Kecerdasan Emosional Melalui Mendongeng Dengan Media Boneka Tangan Pada Anak Kelompok B Di Tk Pertiwi 1 Ngepringan Kecamatan Jenar Kabupaten Sragen Tahun 2013/ 2014

Tujuan penelitian ini adalah untuk mengembangkan kecerdasan emosional anak melalui Mendongeng Dengan Media Boneka Tangan. Dengan jenis penelitian PTK ( Penelitian Tindakan Kelas ). Subyek penelitian ini adalah anak didik kelompok B di TK Pertiwi 1 Ngepringan, Kecamatan Jenar, Kabupaten Sragen Tahun Ajaran 2013/ 2014. Penelitian ini bersifat kolaboratif antara peneliti, guru kelas dan kepala sekolah. Metode pengumpulan data melalui observasi dan catatan lapangan. Teknik analisis data pada penelitian ini dilakukan secara analisis deskriptif kualitatif dengan dua siklus, yang setiap siklusnya dilakukan tiga kali pertemuan dengan anak didik. Hasil penelitian ini menunjukkan adanya perkembangan kecerdasan emosional anak melalui mendongeng dengan media boneka tangan, yakni sebelum tindakan 40%, siklus I mencapai 67% dan siklus II mencapai 80% atau lebih. Kesimpulan dari penelitian ini yaitu Pengembangan Kecerdasan Emosional Anak dapat dilakukan melalui Mendongeng Dengan Media Boneka Tangan

Rio Grande Valley Home

Woman on balcony overlooking courtyard; Illustrated map of Texas and Mexicohttps://scholarsjunction.msstate.edu/cht-sheet-music/12515/thumbnail.jp

Towards an understanding of the political economy of the PPCR

While an analysis of the Pilot Program for Climate Resilience (PPCR) is inseparable from wider discussion on adaptation finance, this article primarily focuses on the drivers and ideologies that shaped the PPCR governance and delivery structures. The core narrative of mainstreaming adaptation into development through a process of government-centred policy reform challenges many principles of the UNFCCC process. Utilising the structures of international financing institutions as implementing agencies, heightens this tension. The central idea of mainstreaming adaptation through climate-proofing existing development initiatives utilises the standard economic growth narrative. This climate ‘add-on’ approach to development allows the World Bank Group and other multilateral development banks (MDBs) to claim a space in managing future climate finance flows. This drive by the Bank plays out in the exclusivity of the design process for the PPCR and through the implementation modalities, which severely curtail opportunities for multi-stakeholder dialogue and thus the potential for development of broad country ownership of programmes

Agreement between physicians and non-physician clinicians in starting antiretroviral therapy in rural Uganda

<p>Abstract</p> <p>Background</p> <p>The scarcity of physicians in sub-Saharan Africa – particularly in rural clinics staffed only by non-physician health workers – is constraining access to HIV treatment, as only they are legally allowed to start antiretroviral therapy in the HIV-positive patient. Here we present a pilot study from Uganda assessing agreement between non-physician clinicians (nurses and clinical officers) and physicians in their decisions as to whether to start therapy.</p> <p>Methods</p> <p>We conducted the study at 12 government antiretroviral therapy sites in three regions of Uganda, all of which had staff trained in delivery of antiretroviral therapy using the WHO Integrated Management of Adult and Adolescent Illness guidelines for chronic HIV care. We collected seven key variables to measure patient assessment and the decision as to whether to start antiretroviral therapy, the primary variable of interest being the Final Antiretroviral Therapy Recommendation. Patients saw either a clinical officer or nurse first, and then were screened identically by a blinded physician during the same clinic visit. We measured inter-rater agreement between the decisions of the non-physician health workers and physicians in the antiretroviral therapy assessment variables using simple and weighted Kappa analysis.</p> <p>Results</p> <p>Two hundred fifty-four patients were seen by a nurse and physician, while 267 were seen by a clinical officer and physician. The majority (> 50%) in each arm of the study were in World Health Organization Clinical Stages I and II and therefore not currently eligible for antiretroviral therapy according to national antiretroviral therapy guidelines. Nurses and clinical officers both showed moderate to almost perfect agreement with physicians in their Final Antiretroviral Therapy Recommendation (unweighted κ = 0.59 and κ = 0.91, respectively). Agreement was also substantial for nurses versus physicians for assigning World Health Organization Clinical Stage (weighted κ = 0.65), but moderate for clinical officers versus physicians (κ = 0.44).</p> <p>Conclusion</p> <p>Both nurses and clinical officers demonstrated strong agreement with physicians in deciding whether to initiate antiretroviral therapy in the HIV patient. This could lead to immediate benefits with respect to antiretroviral therapy scale-up and decentralization to rural areas in Uganda, as non-physician clinicians – particularly clinical officers – demonstrated the capacity to make correct clinical decisions to start antiretroviral therapy. These preliminary data warrant more detailed and multicountry investigation into decision-making of non-physician clinicians in the management of HIV disease with antiretroviral therapy, and should lead policy-makers to more carefully explore task-shifting as a shorter-term response to addressing the human resource crisis in HIV care and treatment.</p

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases, making the pathway a therapeutic target. The similarity between the ATP binding site of protein kinases has made development of specific inhibitors difficult. Current JAK2 inhibitors are not selective and produce unwanted side effects. It is thought that increasing selectivity of kinase inhibitors may reduce the side effects seen with current treatment options. Thus, there is a great need for a selective JAK inhibitor. In this study, we identified a JAK2 specific inhibitor. We first identified key pharmacological interactions in the JAK2 binding site by analyzing known JAK2 inhibitors. Then, we performed structure-based virtual screening and filtered compounds based on their pharmacological interactions and identified compound NSC13626 as a potential JAK2 inhibitor. Results of enzymatic assays revealed that against a panel of kinases, compound NSC13626 is a JAK2 inhibitor and has high selectivity toward the JAK2 and JAK3 isozymes. Our cellular assays revealed that compound NSC13626 inhibits colorectal cancer cell (CRC) growth by downregulating phosphorylation of STAT3 and arresting the cell cycle in the S phase. Thus, we believe that compound NSC13626 has potential to be further optimized as a selective JAK2 drug

tlint101/py50: py50 v0.2.2

&lt;h1&gt;Release Notes py50 v0.2.2&lt;/h1&gt; &lt;p&gt;Reformatted code for maintainability&lt;/p&gt; &lt;h4&gt;Bug fixes &lt;/h4&gt; &lt;p&gt;&lt;strong&gt;Calculations&lt;/strong&gt;&lt;/p&gt; &lt;ul&gt; &lt;li&gt;Renamed the Calculate() class to Calculator() class to match naming convention&lt;/li&gt; &lt;li&gt;Added additional logic for relative_calculation()&lt;ul&gt; &lt;li&gt;Method will now output DataFrame with correct header denoting units (nM or µM)&lt;/li&gt; &lt;/ul&gt; &lt;/li&gt; &lt;li&gt;Separated code logic in Calculator() into distinct methods for future maintenance&lt;/li&gt; &lt;li&gt;Added additional logic for absolute_calculation()&lt;ul&gt; &lt;li&gt;input_units and xscale_units are now consistent if changed from nM to µM to uM&lt;/li&gt; &lt;li&gt;Method will now output DataFrame with correct header denoting units (nM or µM)&lt;/li&gt; &lt;/ul&gt; &lt;/li&gt; &lt;li&gt;Added option &quot;verbose&quot; argument for relative_calculation() and absolute_calculation()&lt;ul&gt; &lt;li&gt;To print out additional information&lt;/li&gt; &lt;/ul&gt; &lt;/li&gt; &lt;/ul&gt; &lt;p&gt;&lt;strong&gt;Plotting&lt;/strong&gt;&lt;/p&gt; &lt;ul&gt; &lt;li&gt;Refactored code for easier maintainability&lt;/li&gt; &lt;li&gt;Added new coding scripts for plotting&lt;/li&gt; &lt;li&gt;Renamed parameters for continuity&lt;/li&gt; &lt;li&gt;Fixed the vline and hline variables in the single_plot_curve(), multi_curve_plot(), and grid_curve_plot()&lt;ul&gt; &lt;li&gt;This is now set to None by default. If else statement will determine its use/starting position&lt;/li&gt; &lt;/ul&gt; &lt;/li&gt; &lt;li&gt;Added &quot;verbose&quot; argument for the single_plot_curve(), multi_curve_plot(), and grid_curve_plot()&lt;ul&gt; &lt;li&gt;To print out additional information&lt;/li&gt; &lt;/ul&gt; &lt;/li&gt; &lt;/ul&gt

tlint101/py50: py50 v0.3.1

&lt;h1&gt;Release Notes py50 v0.3.1&lt;/h1&gt; &lt;h4&gt;Bug fixes &lt;/h4&gt; &lt;p&gt;&lt;strong&gt;Calculations&lt;/strong&gt;&lt;/p&gt; &lt;ul&gt; &lt;li&gt;Fixed pIC50 calculation to function with nM or µM units.&lt;/li&gt; &lt;/ul&gt